The interest of fluticasone nasal spray in COVID-19 related anosmia is still not demonstrated

Lechien, Jérôme R.; Hoch, Cosima C.; Vaira, Luigi Angelo; Saussez, Sven

doi:10.1016/j.amjoto.2021.103008

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…Second, the identification of the pathogenesis [54][55][56][57][58][59][60][61] and risk factors [2][3][4][5][6][7][8][9][10][11][12][62][63][64][65][66][67][68] for the development of persistent CD are in its infancy. For this reason, no effective therapies have yet been found for the prevention and treatment of COVID-19 related POD and PGD [69][70][71][72][73][74][75].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients

Vaira

Gessa

Deiana

et al. 2022

Life

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(1) Background: Persistent olfactory (POD) and gustatory (PGD) dysfunctions are one of the most frequent symptoms of long-Coronavirus Disease 2019 but their effect on the quality of life (QoL) of patients is still largely unexplored. (2) Methods: An online survey was administered to individuals who reported to have had SARS-CoV-2 infection at least 6 months prior with persisting COVID-19 symptoms (using the COVID symptom index), including ratings of POD and PGD, and their physical (PCS) and mental (MCS) components of quality of life were assessed using the standardized short form 12 questionnaire (SF-12). (3) Results: Responses from 431 unique individuals were included in the analyses. The most frequent persistent symptoms were: fatigue (185 cases, 42.9%), olfactory dysfunction (127 cases, 29.5%), gustatory dysfunction (96 cases, 22.3%) and muscle pain (83 cases, 19.3%). Respondents who reported persisting muscle pain, joint pain, fatigue, headache, gastrointestinal disturbances, and dyspnea had significantly worse PCS. Those experiencing persistent fatigue and dyspnea also showed significantly lower MCS. Respondents reporting POD or PGD showed significantly worse QoL, but only pertaining to the MCS. Multiple regressions predicted MCS based on olfactory and marginally on gustatory ratings, but not PCS. Age significantly affected the prediction of PCS but not MCS, and gender and temporal distance from the COVID-19 diagnosis had no effect. (4) Conclusions: POD and PGD are frequent symptoms of the long-COVID-19 syndrome and significantly reduce QoL, specifically in the mental health component. This evidence should stimulate the establishment of appropriate infrastructure to support individuals with persistent CD, while research on effective therapies scales up.

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Section: Discussionmentioning

confidence: 99%

The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients

Vaira

Gessa

Deiana

et al. 2022

Life

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“…In this way, it would be possible to establish which patients should be subjected to specific therapy to prevent the persistence of olfactory dysfunction. 19,36,37…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

et al. 2021

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Objective To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients. Methods Patients underwent psychophysical olfactory assessment with the Connecticut Chemosensory Clinical Research Center test, and determination of blood serum levels of the inflammatory markers D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio within 10 days of the clinical onset of coronavirus disease 2019 and 60 days after. Results Seventy-seven patients were included in this study. D-dimer, procalcitonin, ferritin and neutrophil-to-lymphocyte ratio correlated significantly with severe coronavirus disease 2019. No significant correlations were found between baseline and 60-day Connecticut Chemosensory Clinical Research Center test scores and the inflammatory markers assessed. Conclusion Olfactory disturbances appear to have little prognostic value in predicting the severity of coronavirus disease 2019 compared to D-dimer, ferritin, procalcitonin and neutrophil-to-lymphocyte ratio. The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors.

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“…Although it may affect the recovery time, 11 , 12 the early administration of corticosteroids during the acute phase of infection does not appear to have an effect on the long‐term overall recovery rate. 13 Some preliminary studies reported promising data in the treatment of persistent OD 14 that have not been supported by larger trials 15 , 16 , 17 and meta‐analysis.…”

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confidence: 99%

In reference to Intranasal Corticosteroid Treatment on Recovery of Long‐Term Olfactory Dysfunction Due to COVID‐19

et al. 2022

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The interest of fluticasone nasal spray in COVID-19 related anosmia is still not demonstrated

Cited by 7 publications

References 10 publications

The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients

The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

In reference to Intranasal Corticosteroid Treatment on Recovery of Long‐Term Olfactory Dysfunction Due to COVID‐19

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