The Interactive Effects of VIP, PHI, GHRH and SRIF on the Release of Growth Hormone from Cultured Adenohypophysial Cells in Cattle.

Soliman, Esam Basiouny; Hashizume, Takumi; Ohashi, Satoshi; Kanematsu, Shiceto

doi:10.1507/endocrj.42.717

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…In addition to regulating circadian rhythm, VIP is an important regulator of the GH axis. VIP is known to stimulate GH release in rats in vivo (Bluet-Pajot et al, 1987), in cultured bovine adenohypophysial cells (Soliman et al, 1995), and in perifused bovine adenohypophysis (Hashizume and Kanematsu, 1990). Moreover, loss of VIP or VPAC2 in mice leads to reduced growth in association with reduced circulating IGF-1 levels (Asnicar et al, 2002;Niewiadomski et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice

et al. 2014

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Y-receptors control energy homeostasis, but the role of Npy6 receptors (Npy6r) is largely unknown. Young Npy6r-deficient (Npy6r(-/-)) mice have reduced body weight, lean mass, and adiposity, while older and high-fat-fed Npy6r(-/-) mice have low lean mass with increased adiposity. Npy6r(-/-) mice showed reduced hypothalamic growth hormone releasing hormone (Ghrh) expression and serum insulin-like growth factor-1 (IGF-1) levels relative to WT. This is likely due to impaired vasoactive intestinal peptide (VIP) signaling in the suprachiasmatic nucleus (SCN), where we found Npy6r coexpressed in VIP neurons. Peripheral administration of pancreatic polypeptide (PP) increased Fos expression in the SCN, increased energy expenditure, and reduced food intake in WT, but not Npy6r(-/-), mice. Moreover, intraperitoneal (i.p.) PP injection increased hypothalamic Ghrh mRNA expression and serum IGF-1 levels in WT, but not Npy6r(-/-), mice, an effect blocked by intracerebroventricular (i.c.v.) Vasoactive Intestinal Peptide (VPAC) receptors antagonism. Thus, PP-initiated signaling through Npy6r in VIP neurons regulates the growth hormone axis and body composition.

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Section: Discussionmentioning

confidence: 99%

Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice

et al. 2014

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“…For instance, GHRH and VIP, but not PHI, can increase GH release from bovine pituitary cells. 138 The development of the GHRH/ PACAP family involves initial exon duplication and multiple gene duplications. In the protochordate tunicate, Ciona ( phylum Chordata), there are at least two genes each with exons that can be translated to homologs of GHRH/PRP and PACAP.…”

Section: Direct Effects Of Neurotransmitters On Gh Secretionmentioning

confidence: 99%

Nanobiology and physiology of growth hormone secretion

Anderson

Scanes

2012

Exp Biol Med (Maywood)

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Growth hormone (GH) secretion is controlled by hypothalamic releasing hormones from the median eminence together with hormones and neuropeptides produced by peripheral organs. Secretion of GH involves movement of secretory vesicles along microtubules, transient 'docking' with the porosome in the cell membrane and subsequent release of GH. Release of GH is stimulated by GH releasing hormone (GHRH) and inhibited by somatostatin (SRIF). Ghrelin may be functioning to stimulate GH release from somatotropes acting via the GH secretagogue (GHS) receptor (GHSR). However, recent physiological studies militate against this. In addition, ghrelin does influence GH release acting within the hypothalamus. Release of GH from the somatotropes involves the GH-containing secretory granules moving close to the cell surface followed by transitory fusion of the secretory granules with the porosomes located in multiple secretory pits in the cell membrane. Other peptides/proteins can influence GH secretion, particularly in species of non-mammalian vertebrates.

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“…1983), and the procedures have been adapted not only for cattle (Hashizume et al . 1994b,c, 1997, 2002, 2003a, 2005b, 2008a,b; Soliman et al . 1994, 1995a,b,c, 1997; Hashizume & Kanematsu 1995a,b; Koyama et al .…”

Section: Methods For In Vitro Experiments To Study the Secretion Of Amentioning

confidence: 99%

Methodology for the study of the hypothalamic‐pituitary hormone secretion in cattle

Hashizume

Kasuya

2009

Animal Science Journal

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Studies on the neuroregulatory mechanisms on the secretion of anterior pituitary (AP) hormones in domestic animals are important because nearly all complex physiological and metabolic processes are regulated by the AP hormones. To examine them, this article considers in vivo approaches such as the techniques of intrahypothalamic injection, intracerebroventricular injection, push-pull perfusion, and microdialysis, which have been employed in our own research group for the study in cattle. Also, in vitro approaches such as bovine AP cell culture and the AP explants superfusion system are described. This article clarifies the potential of neuroendocrine study techniques in cattle.

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The Interactive Effects of VIP, PHI, GHRH and SRIF on the Release of Growth Hormone from Cultured Adenohypophysial Cells in Cattle.

Cited by 6 publications

References 25 publications

Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice

Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice

Nanobiology and physiology of growth hormone secretion

Methodology for the study of the hypothalamic‐pituitary hormone secretion in cattle

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