The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad

Wadley, Alexander J.; Zanten, Jet J.C.S. Veldhuijzen van; Aldred, Sarah

doi:10.1007/s11357-012-9402-1

Cited by 84 publications

(84 citation statements)

References 105 publications

(127 reference statements)

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“…Reciprocally, a strong genetically acquired ability in self-repair of the cardiovascular system and a blunted inflammatory response genetically induced might justify the individual probability to remain sheltered from the consequences of vascular alterations and the large individual variability in the susceptibility of all CVD diseases, such as sporadic TAA, even in the presence of potent risk factors. In particular, these suggestions underlined as inflammation can influence both the rate of biological vascular ageing and its complications, such as vascular remodeling and medial degeneration, the typical features of several aorta diseases, including sporadic TAA (Phan et al 2008;Fulop et al 2010;Wadley et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?

Balistreri

Pisano

Martorana

et al. 2014

AGE

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A large variability in occurrence, complications, and age/gender manifestations characterizes individual susceptibility of sporadic thoracic aortic aneurysms (TAA), even in subjects with the same risk factor profiles. The reasons are poorly understood. On the other hand, TAA pathophysiology mechanisms remain unclear than those involved in abdominal aorta aneurysms. However, recent evidence is suggesting a crucial role of biological ageing in inter-individual risk variation of cardiovascular diseases, including sporadic TAA. Biological age rather than chronological age is a better predictor of vascular risk. Relevant assumptions support this concept. In confirming this evidence and our preliminary data, the mean of blood leukocyte telomere length, through use of terminal restriction fragment assay and in blood samples from sporadic TAA patients and controls, was examined. Telomerase activity was also analyzed in two groups. In addition, we verified the weight of genetic inflammatory variants and the major TAA risk factors in telomere/telomerase impairment. Aorta histopathological abnormalities and systemic inflammatory mediators were ultimately correlated with telomere/telomerase impairment. Data obtained demonstrated shorter telomeres and a reduced telomerase activity in TAA patients significantly associated with a genetic inflammatory risk profile, age, gender, smoking, hypertension, a histopathological phenotype, and higher levels of systemic inflammatory mediators than controls. In conclusion, telomere and telomerase activity's detection might be used as predictor biomarkers of sporadic TAA. Their impairment also suggests a strong role of vascular ageing in sporadic TAA, evocated by both environmental and genetic inflammatory factors.

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Section: Discussionmentioning

confidence: 99%

Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?

Balistreri

Pisano

Martorana

et al. 2014

AGE

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“…Many studies attempting to elucidate the mechanisms behind this decline have used animal models (Wu et al, 2014). The key role of endothelium derived NO in protecting the cardiovascular system during ageing is underscored by the findings that eNOS knockout mice exhibit a premature cardiac ageing phenotype associated with early mortality (Li et al, 2004) Among mechanisms that are proposed to contribute to age-dependent endothelial dysfunction, the most acknowledged evidenced the following aspects: (1) reduction of NO bioavailability, caused by diminished NO synthesis and/or by augmented NO scavenging due to oxidative stress; (2) increased oxidative stress in the endothelial microenvironment; (3) increased oxidation of LDL; (4) development of a low-grade pro-inflammatory environment; (5) increased activities of vasoconstrictor factors; (5) impaired endothelial cell function and maintenance repair systems by endothelial progenitor cells (EPC) (El Assar et al, 2012;Wadley et al, 2013;Ungvari et al, 2010).…”

Section: Oxidized Ldl and No Synthesis In Human Vascular Ageingmentioning

confidence: 99%

“…Higher levels of oxidative stress and inflammation are major determinants of reduced vascular function in human ageing, being included in the vascular health triad concept (Wadley et al, 2013). Elevated circulating levels of high sensitivity CRP (hsCRP) and oxidized LDL were associated with CVD (Obradovic et al, 2015); and other inflammatory markers (e.g., tumor necrosis factor-alpha [TNF␣], sVCAM-1, sE-selectin, interleukin [IL]-6, IL-18, and MCP-1) were correlated with age, independently of other cardiovascular risk factors (Ungvari et al, 2010).…”

Section: Oxidized Ldl and No Synthesis In Human Vascular Ageingmentioning

confidence: 99%

Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing

Grădinaru

Borșa²,

Ionescu³

et al. 2015

Mechanisms of Ageing and Development

135

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Oxidized LDL (oxLDL) and nitric oxide (NO) exert contradictory actions within the vascular endothelium microenvironment influencing key events in atherogenesis. OxLDL and NO are so far regarded as representative parameters of oxidative stress and endothelial dysfunction, new targets in prevention, diagnosis and therapy of cardiovascular diseases, and also as candidate biomarkers in evaluating the human biological age. The aim of this review is to explore recent literature on molecular mechanisms and pathophysiological relationships between LDL oxidation, NO synthesis and vascular endothelium function/dysfunction in ageing, focusing on the following aspects: (1) the impact of metabolic status on both LDL oxidation and NO synthesis in relation with oxidative stress, (2) the use of oxidized LDL and NO activity as biomarkers in human studies reporting on cardiovascular outcomes, and (3) evidences supporting the importance of oxidized LDL and NO activity as relevant biomarkers in vascular ageing and age-related diseases.

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“…Multiple lines of evidence suggest that both oxidative stress and inflammation participate in a vicious cycle that can lead to impaired vascular function and CAD (Wadley et al 2013). Chronic low-grade inflammation increases free radical production, causing oxidative stress in the cell (Mangge et al 2014;Soory 2012;Stoner et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation includingCitrus bergamia, in subjects with moderate cardiometabolic risk factors

Babish¹,

Dahlberg

et al. 2016

Can. J. Physiol. Pharmacol.

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Abstract:We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (−7.3%), LDL-cholesterol (−10%), non-HDL cholesterol (−7.1%), cholesterol/HDL (−26%), and apolipoprotein B (−2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (−27%), oxLDL (−19%), LDL/HDL (−25%), triglycerides/HDL (−27%), oxLDL/HDL (−25%), and PAI-1 (−37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.Key words: cardiometabolic disease, bergamot, antioxidant, myeloperoxidase, oxidized LDL, dyslipidemia, HbA1c. Résumé :Les auteurs ont examiné la sécurité et l'efficacité cliniques du F105 chez 11 sujets présentant une dyslipidémie modérée. Le F105 est une combinaison d'extrait de bergamote (Citrus bergamia, EB) et 9 extraits végétaux sélectionnés pour leur capacité à améliorer l'activité antioxydante et anti-inflammatoire de l'EB. In vitro, le F105 montrait une inhibition synergique de la capacité d'absorption des radicaux d'oxygène, de formation de peroxynitrite et de l'activité myéloperoxydase. Après 12 semaines d'administration quotidienne de F105, aucun effet secondaire indésirable relié au traitement ou changements de poids corporels n'étaient observés. Des changements statistiquement significatifs ont été notés quant au cholestérol total (−7,3 %), LDL-cholestérol (−10 %), non-HDL-cholestérol (−7,1 %), cholestérol/HDL (−26 %) et apolipoprotéine B (−2,8 %). Une analyse post hoc de 8 sujets présentant une HbA1c > 5.4 et un indice HOMA-IR >2 ou des triglycérides élevés a révélé des changements additionnels statistiquement significatifs en plus de ceux précédemment observés chez tous les sujets incluant les triglycérides (−27 %), oxLDL (−19 %), LDL/HDL (−25 %) triglycérides/HDL (−27 %), oxLDL/HDL (−25 %), et PAI-1 (−37 %). Une étude de cas de suivi d'une patiente de 70 ans, ne répondant pas à la thérapie par les statines et traitée au F105 quotidiennement, a démontré amélioration des variables cardiométaboliques pendant les 12 semaines similaire au sous-groupe. En résumé, le F105 est bie...

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The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad

Cited by 84 publications

References 105 publications

Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?

Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?

Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing

Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation includingCitrus bergamia, in subjects with moderate cardiometabolic risk factors

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