The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota

Makarewicz, Małgorzata; Drożdż, Iwona; Tarko, Tomasz; Duda-Chodak, Aleksandra

doi:10.3390/antiox10020188

Cited by 173 publications

(141 citation statements)

References 324 publications

(213 reference statements)

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“…Plant-phenolics have been shown to exhibit antimicrobial properties against a wide range of microorganisms, sensitize MDR strains to bacteriostatic or bactericidal antibiotics, and are promising natural antimicrobial weapons ( Miklasińska-Majdanik et al, 2018 ). Due to their direct antimicrobial action and antibiotic modulation activities, dietary polyphenols have recently been demonstrated as chemopreventive and therapeutic agents ( Makarewicz et al, 2021 ). Phenols, including pyrogallol and catechol, demonstrated antimicrobial activity against several microorganisms, including both Gram-positive and Gram-negative bacteria.…”

Section: Phytochemicals For Combating Antibiotic Resistancementioning

confidence: 99%

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

et al. 2021

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Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.

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Section: Phytochemicals For Combating Antibiotic Resistancementioning

confidence: 99%

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

et al. 2021

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“…produce microbial enzymes (e.g., esterase, glucosidase, demethylation, dihydroxylation, and decarboxylation) that can metabolize polymeric polyphenols into low-molecular metabolites that are better absorbed than the parent compound [ 44 , 45 ]. Additionally, several polymeric polyphenols can interact with the surface proteins of gut microbiota to affect their activity and have antibacterial activity [ 46 ]. Multiple in vitro , animal, and human intervention studies have evaluated the impact of mango polyphenols on gut microbial composition.…”

Section: Interactions Between Mango Polyphenols and The Intestinal Microbiotamentioning

confidence: 99%

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions

et al. 2021

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Mango is rich in polyphenols including gallotannins and gallic acid, among others. The bioavailability of mango polyphenols, especially polymeric gallotannins, is largely dependent on the intestinal microbiota, where the generation of absorbable metabolites depends on microbial enzymes. Mango polyphenols can favorably modulate bacteria associated with the production of bioactive gallotannin metabolites including Lactobacillus plantarum, resulting in intestinal health benefits. In several studies, the prebiotic effects of mango polyphenols and dietary fiber, their potential contribution to lower intestinal inflammation and promotion of intestinal integrity have been demonstrated. Additionally, polyphenols occurring in mango have some potential to interact with intestinal and less likely with hepatic enzymes or transporter systems. This review provides an overview of interactions of mango polyphenols with the intestinal microbiome, associated health benefits and underlying mechanisms.

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“…Studies integrating multi-omic approaches have documented the pleiotropic antimicrobial mechanisms by which (poly)phenols modulate gut microbial communities ( 14 , 71 – 75 ). For instance, (poly)phenols can interact with bacterial proteins to inhibit bacterial nucleic acid synthesis, alter cell membrane function and fluidity, modify cell wall integrity and synthesis, affect cell metabolism, and prevent biofilm formation ( 76 ). Likewise, (poly)phenols can inhibit quorum sensing ( 77 , 78 ) and chelate essential metals like iron, copper, and zinc, which are essential to bacteria metabolism ( 79 , 80 ).…”

Section: Reshaping the Gut Microbiota With (Poly)phenol-enriched Diets: Introducing The Concept Of Duplibioticsmentioning

confidence: 99%

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

et al. 2021

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The genome of gut microbes encodes a collection of enzymes whose metabolic functions contribute to the bioavailability and bioactivity of unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, and other omics have expanded the understanding of the different modes of actions by which (poly)phenols modulate the microbiome conferring health benefits to the host. Progress have been made to identify direct prebiotic effects of (poly)phenols; albeit up to date, these compounds are not recognized as prebiotics sensu stricto. Interestingly, certain probiotics strains have an enzymatic repertoire, such as tannase, α-L-rhamnosidase, and phenolic acid reductase, involved in the transformation of different (poly)phenols into bioactive phenolic metabolites. In vivo studies have demonstrated that these (poly)phenol-transforming bacteria thrive when provided with phenolic substrates. However, other taxonomically distinct gut symbionts of which a phenolic-metabolizing activity has not been demonstrated are still significantly promoted by (poly)phenols. This is the case of Akkermansia muciniphila, a so-called antiobesity bacterium, which responds positively to (poly)phenols and may be partially responsible for the health benefits formerly attributed to these molecules. We surmise that (poly)phenols broad antimicrobial action free ecological niches occupied by competing bacteria, thereby allowing the bloom of beneficial gut bacteria. This review explores the capacity of (poly)phenols to promote beneficial gut bacteria through their direct and collaborative bacterial utilization and their inhibitory action on potential pathogenic species. We propose the term duplibiotic, to describe an unabsorbed substrate modulating the gut microbiota by both antimicrobial and prebiotic modes of action. (Poly)phenol duplibiotic effect could participate in blunting metabolic disturbance and gut dysbiosis, positioning these compounds as dietary strategies with therapeutic potential.

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The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota

Cited by 173 publications

References 324 publications

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

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