The Interaction of Suxamethonium With Propanidid and Thiopentone

The frequency of post-suxamethonium pain after pretreatment with small doses of non-depolarizing neuromuscular blocking agents was studied in 299 patients. Gallamine 10 and 20 mg, tubocurarine 5 mg and pancuronium 1 mg were equally effective when a 2-min interval was allowed between their injection and suxamethonium administration. Fazadinium was ineffective and caused difficulty with intubation. No evidence supporting the concept that dosage should be related to patient's weight was found. Inpatients suffered from post-suxamethonium pain as much as did outpatients.

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Cyclophosphamide, Cholinesterase and Anaesthesia*

Walker

Zapif

Mackay

1972

Australian and New Zealand Journal of Medicine

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Summary: A patient receiving cyclophosphamide suffered apnoea and respiratory insufficiency after two anaesthetics in which suxamethonium had been used whilst an anaesthetic without suxamethonium was uneventful; the plasma was found to have a lowered activity of plasma cholinesterase. Accordingly eight patients being treated with cyclophosphamide were tested for plasma cholinesterase activity; in seven there was a significantly depressed level, of the acquired type, as compared with control groups of healthy subjects and patients with comparable diseases not receiving cyclophosphamide. In two patients a fall in cholinesterase activity was demonstrable after cyclophosphamide was begun. Thus appropriate precautions should be taken with patients receiving cyclophosphamide and requiring general anaesthesia: withdrawal of cyclophosphamide, avoidance if possible of depolarising relaxant drugs, or the giving of fresh blood preoperatively to raise the level of plasma cholinesterase.

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The Interaction of Suxamethonium With Propanidid and Thiopentone

Cited by 4 publications

References 10 publications

Prolongation of Suxamethonium-Induced Paralysis by Propanidid

Prolongation of Suxamethonium-Induced Paralysis by Propanidid

Reduction of Post-Suxamethonium Pain by Pretreatment With Four Non-Depolarizing Agents

Cyclophosphamide, Cholinesterase and Anaesthesia*

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