Reduction of Post-Suxamethonium Pain by Pretreatment With Four Non-Depolarizing Agents

Bennetts, F.E.; Khalil, Khaled

doi:10.1093/bja/53.5.531

Cited by 37 publications

(19 citation statements)

References 21 publications

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“…[1718] Literature, however, shows no correlation between fasciculations and postoperative myalgia. [1920] Laurence[17] observed no correlation between myalgia and rise in creatine kinase, an indicator of muscle damage. Collier observed a transient fall in serum calcium levels at 1 min, following succinylcholine administration in patients who had postoperative myalgia and postulated that influx of calcium in to muscle cells caused an increase in muscle damage and pains.…”

Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

Kumar

Talwar

Goyal

et al. 2012

J Anaesthesiol Clin Pharmacol

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Background:Magnesium sulfate and propofol have been found to be effective against succinylcholine-induced fasciculations and myalgia, respectively, in separate studies. A prospective randomized double blind controlled study was designed to assess the effect of a combination of magnesium sulfate with propofol for induction of anesthesia on succinylcholine-induced fasciculations and myalgia.Materials and Methods:Randomly selected 60 adult patients scheduled for elective surgery under general anesthesia were allocated to one of the two equal groups by draw of lots. The patients of MG Group were pretreated with magnesium sulfate 40 mg/kg body weight in 10 ml volume, while patients of NS group were given isotonic saline 0.9% in the same volume (10 ml) intravenously slowly over a period of 10 min. Anesthesia was induced with fentanyl 1.5 mcg/kg and propofol 2 mg/kg, followed by administration of succinylcholine 2 mg/kg intravenously. Muscle fasciculations were observed and graded as nil, mild, moderate, or severe. Postoperative myalgia was assessed after 24 h of surgery and graded as nil, mild, moderate, or severe. Observations were made in double blind manner.Results:Demographic data of both groups were comparable (P > 0.05). Muscle fasciculations occurred in 50% patients of MG group versus in 100% patients of NS group with a significant difference (P < 0.001). After 24 h of surgery, no patient of MG group and 30% patients of NS group had myalgia with a significant difference (P < 0.002).Conclusion:Magnesium sulfate 40 mg/kg intravenously may be used with propofol for induction of anesthesia to control succinylcholine-induced fasciculations and myalgia.

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Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

Kumar

Talwar

Goyal

et al. 2012

J Anaesthesiol Clin Pharmacol

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“…An extensive literature on this subject has been developed, including studies of all the available nondepolarising neuromuscular blockers in a variety of doses (Table 1). These include gallamine, d‐tubocurarine, vecuronium, pancuronium, atracurium and rocuronium [29, 35, 36, 38, 52, 74, 92, 95]. In these studies, different doses and pretreatment administration times were studied.…”

Section: Methods Used To Reduce Myalgiamentioning

confidence: 99%

Succinylcholine‐associated postoperative myalgia

Wong

Chung

2000

Anaesthesia

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SummaryThe subject of postoperative myalgia associated with the use of succinylcholine is reviewed. We discuss the mechanisms of succinylcholine-induced myalgia and the techniques available to prevent and treat the myalgia. In situations where patients are at risk of developing myalgia and succinylcholine is the neuromuscular blocker of choice, the use of a combination of techniques may prove to be a useful strategy.

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“…Assuming a minimum incidence in group S of 25%, then an incidence of 5% or less in group M would be statistically significant. We based these estimates on previously quoted myalgia rates greater than 25% for succinylcholine 8 and 0% for mivacurium 13 .…”

Section: Methodsmentioning

confidence: 99%

Intubation Conditions and Postoperative Myalgia in Outpatient Dental Surgery: A Comparison of Succinylcholine with Mivacurium

Deehan

Henderson

Stewart

2000

Anaesthesia and Intensive Care

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Ninety-four patients undergoing elective outpatient third molar extraction were recruited into a double-blind, randomized, prospective trial comparing mivacurium (group M) with succinylcholine (Group S) for conditions for endotracheal intubation and the occurrence of postoperative myalgia. Anaesthesia was induced with fentanyl 1 µg.kg-1 and propofol 2.5 mg.kg-1 in all patients. Group S patients were given gallamine 20 mg while group M patients were given mivacurium 0.2 mg.kg-1. Manual ventilation was commenced and anaesthesia maintained with nitrous oxide 70% and isoflurane 1 to 2% in oxygen. After two minutes, group S patients were given succinylcholine 1.5 mg.kg-1 and group M patients 0.9% saline. Nasotracheal intubation was performed 30 seconds later. Intubating conditions in group M were significantly better than those in group S (P<0.001). The incidence of postoperative myalgia was 9.5% in group M and 26% in group S but this was not statistically significant (P=0.09). We propose that mivacurium is a suitable neuromuscular blocker to use for endotracheal intubation in outpatient dental surgery.

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Reduction of Post-Suxamethonium Pain by Pretreatment With Four Non-Depolarizing Agents

Cited by 37 publications

References 21 publications

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

Succinylcholine‐associated postoperative myalgia

Intubation Conditions and Postoperative Myalgia in Outpatient Dental Surgery: A Comparison of Succinylcholine with Mivacurium

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