The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells

Lobb, Richard J.; Jacobson, Gregory M.; Cursons, Raymond T.; Jameson, Michael B.

doi:10.3390/ijms19103167

Cited by 25 publications

(20 citation statements)

References 48 publications

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“…However, higher doses of selenium may be toxic for both normal and malignant cells. 84 Similar results were observed for selenium nanocomposites. 85,86 A study showed that selenium has a synergic effect on the response of rat's glioma cells to ionizing radiation.…”

Section: Synergic Effects Of Selenium In Cancer Response To Radiationsupporting

confidence: 71%

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Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells.

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Section: Synergic Effects Of Selenium In Cancer Response To Radiationsupporting

confidence: 71%

“…It has been revealed that low doses of selenium protect normal mononuclear cells, while it has a toxic effect on malignant mononuclear cells. However, higher doses of selenium may be toxic for both normal and malignant cells . Similar results were observed for selenium nanocomposites .…”

Section: Synergic Effects Of Selenium In Cancer Response To Radiationsupporting

confidence: 67%

Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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“…In a recent study, Methylseleninic acid has exhibited substantial cytotoxic effects toward monocytic leukemia cells (THP1) when likened with the healthy peripheral blood mononuclear (PBM) cells. In dose-dependent manner at various concentrations (2.5, 5, and 15 µM for 48 h), Methylseleninic acid showed improved anticancer activity against the malignant THP1 cells (Lobb et al 2018).…”

Section: Methylseleninic Acidmentioning

confidence: 99%

Selenium and selenoproteins: it’s role in regulation of inflammation

2020

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Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.

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“…In vivo and in vitro studies have indicated that MSA is an excellent anticancer agent comparable to SeMet or selenite against a range of cancer models, including lung [102], breast [103,104], melanoma [105], and prostate cancer in particular [106,107,108]. In a recent study, MSA showed significant cytotoxic effects toward monocytic leukemia cells (THP1) compared with the healthy peripheral blood mononuclear (PBM) cells [109]. MSA also enhanced the anticancer activity of radiation and chemotherapeutic drugs (cytosine arabinoside and doxorubicin) in the malignant THP1 cells in a dose-dependent manner (2.5, 5, and 15 µM for 48 h) [109].…”

Section: Se-containing Compounds and Their Usage In Oncologymentioning

confidence: 99%

Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy

Tan

Lau

et al. 2018

IJMS

154

129

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Selenium (Se) acts as an essential trace element in the human body due to its unique biological functions, particularly in the oxidation-reduction system. Although several clinical trials indicated no significant benefit of Se in preventing cancer, researchers reported that some Se species exhibit superior anticancer properties. Therefore, a reassessment of the status of Se and Se compounds is necessary in order to provide clearer insights into the potentiality of Se in cancer prevention and therapy. In this review, we organize relevant forms of Se species based on the three main categories of Se—inorganic, organic, and Se-containing nanoparticles (SeNPs)—and overview their potential functions and applications in oncology. Here, we specifically focus on the SeNPs as they have tremendous potential in oncology and other fields. In general, to make better use of Se compounds in cancer prevention and therapy, extensive further study is still required to understand the underlying mechanisms of the Se compounds.

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The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells

Cited by 25 publications

References 48 publications

Selenium as an adjuvant for modification of radiation response

Selenium as an adjuvant for modification of radiation response

Selenium and selenoproteins: it’s role in regulation of inflammation

Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy

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