The Interaction of Factors VIII and IX

Rg, Macfarlane; Biggs, Rosemary; Bj, Ash; Kw, Denson

doi:10.1111/j.1365-2141.1964.tb00730.x

Cited by 61 publications

(25 citation statements)

References 14 publications

(11 reference statements)

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“…Macfarlane et al (155) extended these experiments, using purified Factor I X activated by contact product. A regeneration of X activator activity after its natural decline could be produced by adding a further quantity of Factor VIII, but not by adding Factor IX.…”

Section: Factor V I I Lmentioning

confidence: 96%

Enzymology and the Blood Clotting Mechanism

Esnouf¹,

Macfarlane²

1968

Advances in Enzymology - And Related Areas of Molecular Biology

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Section: Factor V I I Lmentioning

confidence: 96%

Enzymology and the Blood Clotting Mechanism

Esnouf¹,

Macfarlane²

1968

Advances in Enzymology - And Related Areas of Molecular Biology

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“…When Biggs repeated an experiment she had originally performed in 1951 she discovered that when prothrombin time was measured on Factor VIII-or IX-deficient plasma using a physiological concentration of tissue thromboplastin, the result was abnormal [8]. She postulated that Factor VII ⁄ Ca 2+ ⁄ tissue factor complex was of greater significance than the cascade hypothesis had suggested [9,10]. Other clinical observations raised further questions of the validity of the cascade hypothesis explaining the events of in vivo haemostasis.…”

Section: Tissue Factor and Coagulationmentioning

confidence: 99%

Tissue factor and tissue factor pathway inhibitor

Price

Thompson²,

Kam

2004

Anaesthesia

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SummaryThe classical 'cascade ⁄ waterfall' hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways. Recent molecular biology and clinical data indicate that tissue factor ⁄ factor-VII interaction is the primary cellular initiator of coagulation in vivo. The process of blood coagulation is divided into an initiation phase followed by a propagation phase. The discovery of tissue factor pathway inhibitor further supports the revised theory of coagulation. Tissue factor is also a signalling receptor. Recent evidence has shown that blood-borne tissue factor has an important procoagulant function in sepsis, atherosclerosis and cancer, and other functions beyond haemostasis such as immune function and metastases.

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“…The restriction of replication in sheep occurs immediately after inoculation, but virus can be isolated from many tissues-including peripheral blood leukocytes (PBL), by tissue explantation or cocultivation-for months to years after inoculation (4,5). Furthermore, ease of virus recovery from PBL varies among 376 individual animals but is not affected by the virus-neutralizing antibody which develops later in the infection (6).…”

mentioning

confidence: 99%

Antigenic Shift of Visna Virus in Persistently Infected Sheep

Narayan

Chase

1977

Science

163

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Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenic variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.

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The Interaction of Factors VIII and IX

Cited by 61 publications

References 14 publications

Enzymology and the Blood Clotting Mechanism

Enzymology and the Blood Clotting Mechanism

Tissue factor and tissue factor pathway inhibitor

Antigenic Shift of Visna Virus in Persistently Infected Sheep

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