Antigenic Shift of Visna Virus in Persistently Infected Sheep

Narayan, Opendra; De, Giulia; Chase, Jeanne H.

doi:10.1126/science.195339

Cited by 163 publications

(74 citation statements)

References 9 publications

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“…Serum from Icelandic sheep persistently infected with visna virus neutralized the inoculum strain of virus, but not the virus isolated at the time of collection of serum (Gudnadottir, 1974). Similar findings were subsequently reported in infected Border Leicester and Hampshire sheep (Narayan et al, 1977(Narayan et al, a, b, 1978. The antigenic variation in visna virus was shown to result from oligonucleotide changes in the T-terminal region of the viral genome (Clements et al, 1982) which is the region that codes for the envelope glycoproteins of the virus.…”

Section: Introductionsupporting

confidence: 77%

Antigenic Variation of Caprine Arthritis-Encephalitis Virus during Persistent Infection of Goats

Ellis

Wilcox

Robinson

1987

Journal of General Virology

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SUMMARYSix caprine arthritis-encephalitis virus (CAEV)-free goats kept in strict isolation were inoculated intravenously with a cloned CAEV isolate (virus 020). At 78 weeks post-infection a virus (virus 095) isolated from one of the goats was shown to have the characteristics of CAEV, but was antigenically distinct from virus 020 and two other CAEV isolates by serum neutralization tests. Serum from the goat that had the variant virus neutralized the inoculum virus and the variant virus but serum from other inoculated goats neutralized only the inoculum virus. The variant virus and the inoculum virus were shown to co-exist in the infected goat, but the presence of the antigenic variant did not appear to be associated with an increase in severity of lesions compared with other inoculated goats.

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Section: Introductionsupporting

confidence: 77%

Antigenic Variation of Caprine Arthritis-Encephalitis Virus during Persistent Infection of Goats

Ellis

Wilcox

Robinson

1987

Journal of General Virology

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“…Genome analyses have shown that SRLVs are highly heterogeneous [6,24,86,89,98,99,139,154]. This is also a notable feature of MVV and CAEV strains.…”

Section: Serological Testsmentioning

confidence: 97%

Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes

et al. 2004

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-Small ruminant lentiviruses (SRLV = maedi-visna in sheep and caprine arthritis encephalitis in goats) are distributed throughout most countries of the world, particularly Europe. Laboratories from 16 European countries established collaborations within the framework of a COST (CO-operation in the field of Scientific and Technical Research) action sponsored by the European Union in order to (i) better organize their research programmes on SRLVs and (ii) to coordinate efforts to combat these two diseases. After five years, a consensus conference -the first one in the veterinary medicine field -concluded the work of this network of laboratories by reviewing the present position and discussing three important questions in the field of SRLVs: routes of transmission, consequences of infection and potential role of eradication programmes at either a European or local level, according to the situation in each country or region. This paper brings together existing information regarding these questions and identifies areas for future research.Maedi-visna / caprine arthritis-encephalitis virus / lentivirus / small ruminants / European consensus conference

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“…Neutralization escape mutants of the animal lentiviruses such as equine infectious anemia virus, visna virus, and simian immunodeficiency virus evolve in infected horses, sheep, and rhesus monkeys, respectively (6)(7)(8). Neutralizing antibody responses against autologous HIV-1 were reported first by Weiss in 1986 (9), and several later studies have suggested that its appearance is slow to develop and of low titer (2,4,5).…”

mentioning

confidence: 99%

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

Richman¹,

Wrin²,

Little³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

1,081

1,088

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A recombinant virus assay was used to characterize in detail neutralizing antibody responses directed at circulating autologous HIV in plasma. Examining serial plasma specimens in a matrix format, most patients with primary HIV infection rapidly generated significant neutralizing antibody responses to early (0 -39 months) autologous viruses, whereas responses to laboratory and heterologous primary strains were often lower and delayed. Plasma virus continually and rapidly evolved to escape neutralization, indicating that neutralizing antibody exerts a level of selective pressure that has been underappreciated based on earlier, less comprehensive characterizations. These data argue that neutralizing antibody responses account for the extensive variation in the envelope gene that is observed in the early months after primary HIV infection.

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Antigenic Shift of Visna Virus in Persistently Infected Sheep

Cited by 163 publications

References 9 publications

Antigenic Variation of Caprine Arthritis-Encephalitis Virus during Persistent Infection of Goats

Antigenic Variation of Caprine Arthritis-Encephalitis Virus during Persistent Infection of Goats

Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

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