The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei, Parvin; Damirchi, Arsalan; Hoseini, Rastegar

doi:10.5717/jenb.2015.15070703

Cited by 25 publications

(12 citation statements)

References 91 publications

(80 reference statements)

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“…Contrarily, hypovitaminosis D (a decrease in vitamin D) results in the increased levels of parathyroid hormone (PTH) and intercellular Ca ++ and inhibits insulin receptors in target tissues and closes the Glut-4 channel. In addition, since insulin secretion depends on the intracellular calcium concentration, hypovitaminosis D may impair insulin function, glucose metabolism, and other metabolic processes in the adipose tissue, which might be another mechanism in the association of abdominal obesity and low levels of vitamin D (37,40). A further reduction in anthropometric indices induced by aerobic training plus vitamin D supplementation, compared to other groups, in the current study was probably due to the higher sensitivity of visceral adipocytes, which stimulated lipolysis in response to catecholamines.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

2019

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Background:Recent studies indicate that aerobic training may affect non-alcoholic fatty liver disease (NAFLD). Besides, vitamin D and NAFLD are known to have more than just an association. Objectives: This study aimed to examine the effects of vitamin D supplementation, combined with aerobic training, on anthropometric indices in elderly women with NAFLD and vitamin D deficiency. Methods: We randomly divided 40 elderly women with NAFLD and vitamin D deficiency into four groups: aerobic training + vitamin D supplementation (AT + Vit. D), aerobic training (AT), vitamin D supplementation (Vit. D), and control (C). The AT protocol consisted of 40 -60 minutes of aerobic training at 60% -75% of HRmax three times a week for eight weeks. The anthropometric indices included body weight (BW), body mass index (BMI), body fat percentage (BFP), and waist-hip ratio (WHR) measured at the start and after eight weeks of the study. Data were analyzed by paired t-test and ANOVA using SPSS version 21.0 software at a significance level of P < 0.05. Results: Anthropometric indices (BW, BMI, BFP, and WHR) significantly changed in all groups, with a significant increment in the control group and decrement in the AT + Vit. D, AT, and Vit. D groups. No significant differences were observed between the AT + Vit. D, AT, and Vit. D groups in the measured variables. Conclusions: Vitamin D supplementation combined with aerobic training improves the anthropometric indices in elderly women with NAFLD.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

2019

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“… 14 15 Adipokines are an exciting new link between obesity, insulin resistance and CVD. 15 16 Apelin is a recently identified bioactive adipokine. It is an endogenous of the orphan seven-transmembrane (TM) domain G protein-coupled receptor, putative receptor protein related to the angiotensin receptor AT1 (APJ), which is functionally similar to angiotensin-1 coupled receptor.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Estrogen Replacement Therapy on Visceral Fat, Serum Glucose, Lipid Profiles and Apelin Level in Ovariectomized Rats

et al. 2017

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ObjectivesOvarian hormones have been shown to regulate body weight, intra-abdominal fat accumulation and plasma level of cytokines. The aim of this study was to investigate the effect of estrogen replacement therapy on visceral adipose tissue, plasma level of apelin, lipid profiles, and glucose in ovariectomized (OVX) rats.MethodsThirty female Wistar rats were divided into OVX (n = 20) and sham (n = 10) groups. OVX rats were subdivided into estrogen replacement therapy (OVX+est; n = 10) receiving 17 β-estradiol valerates (30 µg/kg, s.c., 5 day/week, for eight weeks), and vehicle control group receiving sesame oil same as experiment group (OVX+ses oil; n = 10). After the treatments, all groups were sacrificed and blood samples were collected, visceral fats were taken from the abdominal cavity and weighed immediately. Apelin were measured using enzyme-linked immunosorbent assay kits. Lipid profiles and glucose were measured using the enzymatic colorimetric method. Data were analyzed with one-way analysis of variance and (P < 0.05) determined as the statistical significance level.ResultsAfter eight weeks, body weight, body mass index (BMI), visceral fat, apelin and lipid profiles (P < 0.01) were increased significantly in OVX rats compared to sham group. Treatment with estrogen leads to significant reduction in body weight and BMI (P < 0.05), there was no significant change in serum apelin level in OVX+est rats compared to OVX+ses.ConclusionsThese results suggest that estradiol replacement therapy successfully attenuated some of the metabolic syndrome components, and apelin does not probably stand as a mediator of these physiological functions.

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“…In parallel to our study, Hoseini et al (25) reported that high doses of vitamin D could significantly reduce BW, BMI, and visceral fat in rats with metabolic syndrome. Also, Babaei et al (26) observed that a combination of AT and Vit D reduced TC, TG, and LDL and increased HDL in ovariectomized rats. Regarding the use of fat as fuel both in exercising and in recovery states, it appears that exercise is an LDL-reducing factor.…”

Section: Discussionmentioning

confidence: 97%

“…Calcium may also cause the fecal excretion of bile acids by binding to it and cholesterol serum levels are reduced due to the reproduction of bile acids from cholesterol. Therefore, vitamin D is expected to reduce TG, LDL, and cholesterol levels by increasing intracellular calcium (26,29). receptors in target tissues and closes the Glut-4 channel, leading to impaired insulin function, glucose metabolism, and other metabolic processes, which might be another mechanism (31,32).…”

Section: Discussionmentioning

confidence: 99%

Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial

2020

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Background: Lifestyle intervention is considered first-line therapy for Nonalcoholic Fatty Liver Disease (NAFL). Objectives: Here, we aimed to compare the effect of combined Aerobic Training (AT) and Vitamin D (Vit D) supplementation on NAFLD in elderly women with Vit D deficiency. Methods: We recruited 40 women (60 -65 years) with NAFLD (second or third grade) and Vit D deficiency. Then, using simple randomization, the subjects were assigned to four groups including aerobic training (AT; 60% -75%, 20 -40 min/day, 3 days/wk running and walking), vitamin D supplementation (Vit D; 50,000 IU one day/week), aerobic training plus vitamin D supplementation (AT + Vit D), and sedentary control (C; placebo). The data were analyzed using paired t-test and one-way analysis of variance and Tukey's post hoc test with SPSS21 at a significance level of P < 0.05. Results: After eight weeks of intervention, fatty liver grade markedly reduced in the AT + Vit D, AT, and Vit D groups (60%, 38.88%, and 22% respectively). However, it increased by 17.60% in the control group. The combination of AT + Vit D significantly reduced liver enzymes, anthropometric indices, and glycemic indices and improved lipid profile. All groups demonstrated a significant inverse correlation between vitamin D and fatty liver grade. Conclusions: A sedentary lifestyle and Vit D deficiency accelerate the NAFLD probably by deteriorating hepatic risk factors. Additionally, adequate levels of plasma vitamin D are necessary to achieve the beneficial metabolic effects of aerobic training.

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The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Cited by 25 publications

References 91 publications

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

The Effect of Estrogen Replacement Therapy on Visceral Fat, Serum Glucose, Lipid Profiles and Apelin Level in Ovariectomized Rats

Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial

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