The interaction between RAGE gene polymorphisms and HPV infection in determining the susceptibility of cervical cancer in a Chinese population

Xu, Qian; Xue, Fengxia; Yuan, Baoyu; Zhang, Linqin; Li, Jie; He, Zhu

doi:10.3233/cbm-2012-00277

Cited by 19 publications

(26 citation statements)

References 23 publications

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“…In the present study, we observed the 82G>S genotype frequencies were: GG: 18.95%, GS: 43.16%, SS: 37.89%. The 82G>S genotype distribution in our study was consistent with the genotype frequencies from cervical cancer [28]. Consistent with the results from Chinese cervical cancer patients, our study also suggests that carriage of 82SS genotype of 82G>S polymorphism predicts a significantly higher risk for EOC incidence.…”

Section: Discussionsupporting

confidence: 81%

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Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients

Zhang

Hou

et al. 2013

Cell Physiol Biochem

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Background: Given the roles of receptor for advanced glycation end products (RAGE) in the pathogenesis of carcinogenesis, we propose that RAGE polymorphisms may be associated with risk of epithelial ovarian carcinoma (EOC). Method: This case-control study included 190 women over 40 years of age who were diagnosed with primary EOC and 210 healthy control subjects. RAGE gene polymorphisms, including 82G>S,-374T>A,-429C>T,and 1704G>T were determined. Results: We found that only the frequencies of the 82G>S polymorphisms were significantly different between the EOC cases and controls. The 82SS genotype was significantly higher in EOC patients than in controls (37.89% vs. 23.33%,P<0.001). With the 82 GG genotype as reference, the OR for 82SS homozygous carriers reached to 2.65 (95% CI: 1.54-4.58; P =0.0004) after adjustment for age, smoking status, body mass index, family history, usage of contraceptives, tubal ligation history, use of menopausal hormones and menopausal status. The 82S allele carriage presented a higher risk for EOC (OR=1.71; 95% CI, 1.29-2.26; P=0.0002). The polymorphisms of 1704G>T,-374T>A and -429C>T did not affect the EOC risk. Conclusion: This result suggests that the 82G>S polymorphism of RAGE gene may be associated with the susceptibility of EOC.

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Section: Discussionsupporting

confidence: 81%

“…The 82SS genotype was associated with elevated risk for cervical cancer. In addition, the 82SS carriers had significantly lower serum soluble RAGE levels than 82GS and 82GG[28]. In the present study, we observed the 82G>S genotype frequencies were: GG: 18.95%, GS: 43.16%, SS: 37.89%.…”

Section: Discussionsupporting

confidence: 62%

Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients

Zhang

Hou

et al. 2013

Cell Physiol Biochem

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“…To date, numerous genetic variants have been identified in the RAGE gene, the majority of which are single-nucleotide polymorphisms (SNPs; Schmidt and Stern 2000). Ample studies have suggested that several RAGE gene polymorphisms, alone or in combination with other factors, are associated with the development or progression of various types of cancer, including gastric, lung, colorectal, breast, cervical, and ovarian cancer (Schenk et al 2001;Tesarova et al 2007;Gu et al 2008;Xu et al 2012;Zhang et al 2013;Qian et al 2014;). Such variations in genomic sequence have a potential to alter the function or expression of RAGE (Hudson et al 2001;Hofmann et al 2002), leading to changes in its final bioavailability and, thus, the carcinogenesis.…”

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confidence: 99%

RAGE Gene Polymorphism and Environmental Factor in the Risk of Oral Cancer

Chien

Lin

et al. 2015

J Dent Res

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Oral squamous cell carcinoma is a common neoplasm that is known to be causally associated with genetic factors and environmental carcinogens. The receptor for advanced glycosylation endproducts (RAGE) is a transmembrane protein of the immunoglobulin superfamily with broad specificity for multiple ligands, and it has been shown to play vital roles in several pathophysiologic processes, including diabetes, Alzheimer disease, renal disease, cardiovascular disease, and cancer. The present study aimed to assess the influences of RAGE gene polymorphisms, combined with environmental carcinogens on the predisposition to oral tumorigenesis. Five polymorphisms of the RAGE gene—including −374T>A (rs1800624), −429T>C (rs1800625), 1704G>T (rs184003), Gly82Ser (rs2070600), and a 63-bp deletion allele (−407 to −345)—were examined from 592 controls and 618 patients with oral cancer. We found that individuals carrying the polymorphic allele of rs1800625 are more susceptible to oral cancer (odds ratio [OR], 1.899; 95% confidence interval [CI], 1.355 to 2.661; adjusted OR [AOR], 2.053; 95% CI, 1.269 to 3.345) after adjustment for age, sex, betel nut chewing, and tobacco consumption. Moreover, we observed a significant association of rs1800625 variants with late-stage tumors (stage III/IV, OR, 1.736; 95% CI, 1.126 to 2.677; AOR, 1.771; 95% CI, 1.101 to 2.851) and large-size tumors (>2 cm in the greatest dimension; OR, 1.644; 95% CI, 1.083 to 2.493; AOR, 1.728; 95% CI, 1.089 to 2.741). Based on behavioral exposure of environmental carcinogens, the presence of 4 RAGE single-nucleotide polymorphisms (SNPs), combined with betel quid chewing and/or tobacco use, greatly augmented the risk of oral cancer. In addition, carriers of particular haplotypes of the 4 RAGE SNPs examined are more prone to develop oral cancer. These results indicate an involvement of RAGE SNP rs1800625 in the development of oral squamous cell carcinoma and implicate the interaction between RAGE gene polymorphisms and environmental mutagens as a predisposing factor of oral carcinogenesis.

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“…HPV comprises a double-stranded closed circular DNA which specifically infects the squamous epithelial cells of human skin and mucous membranes and an icosahedral non-enveloped virus composed of core DNA and OPN. OPN is a glycoprotein and major capsid protein, which is highly conserved among HPV types and is the main group-specific antigen (20,21). OPN has several important functions due to its structural characteristics and accurate antigenic characteristics, including adhesion to host cells, identification of virus receptors and assisting endocytosis and transport of viral DNA (22).…”

Section: Discussionmentioning

confidence: 99%

Detection of human papillomavirus and expression of osteopontin in cervical cancer specimens

Qin

Jia

Ren

et al. 2014

Molecular Medicine Reports

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Abstract. To understand human papillomavirus (HPV) and expression of osteopontin (OPN) in cervical diseased tissues, HPV infection was detected in paraffin-embedded specimens of cervical lesions from 90 patients with cervical cancer. Three polymerase chain reaction (PCR) techniques were used to determine the detectable rate of HPV infection. Expression of HPV OPN protein was detected using immunohistochemical methods. When a pairwise comparison was made among the three PCR methods, χ 2 analysis indicated P>0.05 for detection through the methods of MY09/11 and GP5 + /6 + , and P>0.05 through the methods of MY09/11 and Nested-PCR. This indicated that there was no statistically significant difference in the HPV infection detection sensitivity of these methods. However, χ 2 comparison of the methods of GP5 + /6 + and Nested-PCR indicated P<0.05, which demonstrated that there was a statistically significant difference. The rate of positive HPV DNA measured with Nested-PCR was significantly higher than that measured using the GP5 + /6 + PCR method. The HPV OPN protein is expressed in cervical cancer, and the HPV OPN polypeptide antibody has broad spectrum reaction capacity and significant multivalence for HPV infection. Immunohistochemical detection was performed on tissue specimens using the purified rabbit HPV OPN polypeptide antibody. Sixty-one cases exhibited a positive result and 29 a negative result. The total rate of positive detection was 67.78%. HPV OPN may therefore serve as a candidate target for tumor treatment, including targeted therapies and vaccine development.

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The interaction between RAGE gene polymorphisms and HPV infection in determining the susceptibility of cervical cancer in a Chinese population

Abstract: Our results suggest that the RAGE 82G>S polymorphisms, interacting with HPV infection, are implicated in the occurrence of cervical cancer.

Cited by 19 publications

References 23 publications

Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients

Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients

RAGE Gene Polymorphism and Environmental Factor in the Risk of Oral Cancer

Detection of human papillomavirus and expression of osteopontin in cervical cancer specimens

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