The Interaction Between Levofloxacine Hydrochloride and DNA Mediated by Cu²⁺

Abstract

Levofloxacin (LEV) is a fluoroquinolone antimicrobial agent. LEV also inhibits DNA synthesis and is bactericidal. The mechanisms of the interaction among LEV, DNA and Cu2+ are studied by fluorescence method. In the paper, the results show that LEV and Cu2+ can form binary complex, and also LEV and DNA can form complex mediated by Cu2+. The composition of the complex is determined. The affects to the reaction are also found.

Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure–activity relationship

“…This behavior is of great importance with regard to the relevant biological role of quinolone antibiotics in the body [52]. …”

Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin

“…24 This behavior is of great importance with regard to the relevant biological role of fluoroquinolone antibiotics in the human body. 25 The absorption spectra (Fig. 4) of the interaction of complex 1 with calf-thymus DNA have been recorded for a constant DNA concentration (3.125 · 10 À4 M) in different complex: calf-thymus DNA mixing ratios (r).…”

Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA–interaction approach

“…The quinolone metal complex can bind to DNA via three distinct binding sites namely, groove-binding, binding to the phosphate group and intercalation [53]. These behaviours are of great importance with regard to the relevant biological role of quinolone antibiotics in the body [54,55].…”