The Inter‐relationship of Pituitary Hormones and the Maintenance of Lactation*

Huntingford, Peter J.

doi:10.1111/j.1471-0528.1963.tb15034.x

Cited by 5 publications

(1 citation statement)

References 68 publications

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“…This is consistent with the results from carefully conducted clinical trials in which it was considered unnecessary to invoke a hypothetical central PRL-releasing effect of oxytocin since the adminstration of exogenous oxytocin neither obviously affected the course of lactation, nor did it help women with inadequate lactation (Huntingford 1963). The administration of this neuropeptide to normal volunteers in the acute trial and to postpartum women for seven consecutive days in the early puerperium, as shown here, did not modify the amount of milk secreted or influence plasma PRL.…”

Section: Discussionsupporting

confidence: 89%

Failure of Oxytocin and Lysine-Vasopressin to Stimulate Prolactin Release in Humans

Pozo¹,

Kleinstein²,

Re³

et al. 1980

Horm Metab Res

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In order to test a possible stimulatory effect of oxytocin and lysine-vasopressin on prolactin (PRL) release six female volunteers received either saline or 1 IU oxytocin (Syntocinon) i.v.. Blood sampling was performed at intervals over 90 minutes. Nine puerperae were treated with oral oxytocin (Sandopart) 50 IU t.i.d. for seven days. Nine other untreated postpartum women served as controls. Blood was collected before delivery and on subsequent postpartum days, and the milk volumes produced were estimated by increases in the babies' weight. In addition, seven volunteers received 5 or IU lysine-vasopressin (Vasopressin) i.m. Blood was withdrawn at regular intervals for 180 minutes, the urine volumes excreted in 30-minute intervals were measured and the clearance of free water calculated. Oxytocin failed to modify basal plasma PRL in the acute trial and in the post-partum women, and milk amounts produced were not influenced by treatment. Vasopressin did not change the PRL plasma profile despite a significant (p less than 0.05) reduction in the excretion of free water. Results indicate that neuropeptides are not implicated in the control of PRL release.

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Section: Discussionsupporting

confidence: 89%

Failure of Oxytocin and Lysine-Vasopressin to Stimulate Prolactin Release in Humans

Pozo¹,

Kleinstein²,

Re³

et al. 1980

Horm Metab Res

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Induced Lactation

Auerbach¹

1981

Am J Dis Child

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\s=b\ Induced lactation is breast-feeding without prior pregnancy. Preparation includes breast and nipple stimulation, supplementing the maternal diet, and occasional use of hormones. Infants younger than 8 weeks are more willing to nurse than infants older than 8 weeks. Previous lactation experience is related to increased likelihood of milk production, decreased need for supplemental fluids, and duration of breast-feeding. Tandem nursing an older biological infant and the adoptive infant does not guarantee an increase in milk production sufficient to meet the adoptive infant's needs. Three fourths of the women who took part in this questionnaire survey evaluated their experience positively, regardless of infant age at weaning or need for supplemental fluids. Most respondents stressed the maternal-infant relationship and its enhancement through breast-feeding, rather than milk production, as the reason for attempting induced lactation.(Am J Dis Child 1981;135:340-343)Adoptive nursing is not a new idea, XjL but it has received little more than speculative treatment in the literature.1-' As breast-feeding is hormonally and physiologically linked to pregnancy, many professionals have expressed doubt that it is possible to produce milk through suckling stimu¬ lation alone.46 Occasional reference to adoptive nursing continues to excite interest because little is known about it and because success is considered unlikely. As part of a retrospective study of relactation/induced lacta¬ tion, we sought to determine (1) why a mother would choose to breast-feed an adopted infant, (2) how she would go about preparing to nurse her nonbiological baby, (3) to what extent mater¬ nal history affects her experience, (4) in what way or ways the infant influences the induced lactation expe¬ rience, and (5) the most appropriate way to assess success with adoptive nursing. METHODS SourcesRespondents were obtained through sev¬ eral sources. Secondary referral included contacting women whose names were obtained from the manufacturer of a nursing trainer (Lact-Aid Nursing Train¬ er, Resources in Human Nurturing Inter¬ national, Denver), breast-feeding support organizations, and persons who had contact with adoptive nursing mothers.Primary referral occurred when persons responded to announcements of the study inviting participation of mothers who had nursed an adopted baby. Participants com¬ pleted a detailed, 15-page self-report ques¬ tionnaire that included adoptive nursing episodes from 1970 to 1977. The modal year of initiation of induced lactation was 1976. Study PopulationTwo hundred forty women from the United States and three British Common-wealth countries participated, repre¬ senting three fourths of the persons con¬ tacted. They were characterized by the following three distinct maternal histories: group 1, those who had never been preg¬ nant and had never lactated before nursing their adopted baby (N = 83); group 2, those who had been pregnant but who had never lactated before (N = 55); and group 3, those who had nursed one or...

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The Existence of a Luteolytic Hormone in the Uterus of the Guinea-Pig

Donovan¹

1967

Reproduction in the Female Mammal

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The Inter‐relationship of Pituitary Hormones and the Maintenance of Lactation*

Cited by 5 publications

References 68 publications

Failure of Oxytocin and Lysine-Vasopressin to Stimulate Prolactin Release in Humans

Failure of Oxytocin and Lysine-Vasopressin to Stimulate Prolactin Release in Humans

Induced Lactation

The Existence of a Luteolytic Hormone in the Uterus of the Guinea-Pig

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