The Existence of a Luteolytic Hormone in the Uterus of the Guinea-Pig

Donovan, B. T.

doi:10.1007/978-1-4899-6377-2_18

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…This is in contrast to observations by Donovan (1966), who implanted pituitaries from young or adult guinea-pigs beneath the kidney capsule of intact female guinea-pigs and observed no cycle extension in the graft-bearing animals.…”

Section: Discussioncontrasting

confidence: 85%

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

Das¹,

Benson²

1970

Journal of Endocrinology

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Pituitaries from adult or young guinea-pigs were implanted under the kidney capsule of intact adult female guinea-pigs between the 3rd and 5th days of the oestrous cycle.The oestrous cycles in the recipients ofadult pituitaries were mostly normal in length. Seven out of nine animals engrafted with pituitaries from their own litters had a prolonged dioestrus, ranging from 8 to 16 days longer than normal, at the end of which oestrus and ovulation occurred. When the grafts contained pituitaries from one male and one female pup the cycle extension was more pronounced than when they were composed of pituitaries from two or three female pups.

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Section: Discussioncontrasting

confidence: 85%

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

Das¹,

Benson²

1970

Journal of Endocrinology

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“…In view of other evidence establishing the local nature of the uterine control of ovarian function (Donovan, 1967 ;Fischer, 1967) it is remarkable that enlargement of the luteal bodies on the side of uterine ablation in the hemi-hysterectomized animals (Group 5) did not take place for eight days after hormone treatment. This observation could be taken to imply that the output of luteolytic factor was unusually high, as sufficient of this substance might have been secreted from the remaining uterine horn to inhibit luteal growth in the opposite ovary.…”

Section: Discussionmentioning

confidence: 96%

Growth and Regression of the Corpora Lutea Formed in Guinea-Pigs in Response to Treatment With Exogenous Gonadotrophin

Donovan¹,

Lockhart²

1972

Journal of Endocrinology

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The growth and functional activity of luteal bodies formed in the ovaries of guinea-pigs given exogenous gonadotrophin was examined. Folliclestimulating hormone, luteinizing hormone, both hormones together, and both hormones supplemented with prolactin, were given on day 13. Vaginal oestrus occurred 8-12 days later, irrespective of the kind of hormone given. The sizes of luteal bodies induced in intact and hysterectomized guinea-pigs were compared with those of similarly aged naturally formed corpora lutea 8 and 11 days after ovulation. The artificially induced bodies were smaller than normal corpora lutea, but grew to match their size after hysterectomy.

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“…This uterine influence is luteolytic, for the surgical removal of the uterus allows a corpus luteum to persist indefinitely. Future research may show that uterine inflammation, by producing an increase in the number and synthetic activity of uterine cells, can enhance the secretion of a uterine luteolytic substance (Donovan, 1967). ACKNOWLEDGMENT Supported in part by Public Health Service Grants E-01831 and AI-0567-04.…”

Section: Discussionmentioning

confidence: 99%

The Role of Inflammation in the Uterine Weight Increase Caused by an Iud

Parr¹

1969

Reproduction

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Foreign bodies in the uteri of germ-free and conventional rats caused a weight increase only in those portions of the uterus where there was an inflammatory reaction. In oestrogen-deprived, conventional animals, uterine inflammation prevented involution and the disappearance of nucleoli from the endometrium. It appears that inflammation is responsible for the weight increase in uteri containing foreign bodies. It is suggested that inflammation may also be responsible for the luteolytic effect of uterine foreign bodies.

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The Existence of a Luteolytic Hormone in the Uterus of the Guinea-Pig

Cited by 9 publications

References 36 publications

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

Growth and Regression of the Corpora Lutea Formed in Guinea-Pigs in Response to Treatment With Exogenous Gonadotrophin

The Role of Inflammation in the Uterine Weight Increase Caused by an Iud

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