The Intensity of Chronic Catarrhal Gingivitis in Children Depending on the Age

Hasiuk, P. А.; Malko, N. V.; Vorobets, Anna; Ivanchyshyn, Viktoriya V; Rosolovska, Svitlana O; Korniienko, Mariia M; Bedenyuk, Oleksandr A

doi:10.36740/wlek202005102

Cited by 15 publications

(8 citation statements)

References 4 publications

(2 reference statements)

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“…The development of experimental periodontitis, like any other inflammatory process [18] , is accompanied by an increase in the intensity of lipid peroxidation processes [19] , resulting in an increase in endogenous intoxication [20] . Increased permeability of erythrocyte membranes is a reflection of the disorders of the functions and structure of plasma membranes of all cells of the body.…”

Section: Discussionmentioning

confidence: 99%

Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis

Demkovych¹

2023

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Introduction: Excessive lipoperoxidation is accompanied by accumulation of peroxidation products and depletion of antioxidant re-serves, which cause hyperenzymemia and the accumulation of toxic substances. The level of endotoxicosis is determined by the content of hydrophilic and hydrophobic products in the blood.  Aim: To define the pathogenetic role of endogenous intoxication in the dynamics of development of experimental periodontitis of bacterial-immune genesis.  Materials and methods: The experiment was conducted on rats. The animals were divided into three groups: group 1 – control group/intact; group 2 – model periodontitis at 7 days; group 3 – model periodontitis at 30 days. The experimental bacterial-immune periodon-titis was induced by injection into the tissue of the periodontal complex of the microorganisms’ mixture diluted with egg’s albumin. For the study, we selected the blood serum in which the content of middle molecular weight molecules and erythrocyte intoxication index were determined. The results were statistically analyzed by means of non-parametric indices methods.  Results: The development of generalized periodontitis is characterized by the occurrence of oxidative stress, which leads to violation of the metabolism in the mucous membrane of the oral cavity resulting in the accumulation of toxic products and the development of endogenous intoxication. The results show that the content of middle molecular weight molecules (aromatic amino and chain amino acids) determined on day 7 of the experiment was 1.11 times higher than that of the control group (p<0.01) and by 1.16 times (p<0.01), respectively. Comparing the levels of the above hydrophilic components of endogenous intoxication at 30 days of experimental peri-odontitis, we found a probable increase in these indicators compared with those at 7 days of the experiment. Studying the level of eryth-rocyte intoxication index, we found that at 7 days of experimental periodontitis this index was 1.28 times higher (p<0.01) than that of the intact group and continued to increase at 30 days. Conclusions: The dynamics of experimental periodontitis of bacterial-immune genesis show that the highest rates of endogenous intoxication are found in the late stages of the dynamics of the inflammatory process in the periodontium, namely at 30 days of the experiment, which may indicate chronic inflammation.

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Section: Discussionmentioning

confidence: 99%

Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis

Demkovych¹

2023

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“…These factors lead to damage to the vascular wall, an increase in the number of dormant capillaries, parietal prolapse of thrombotic masses, disruption of transport systems in the walls of blood vessels, and others. An important place in the pathogenesis of microcirculation disorders is occupied by LPS, which leads to disintegration and destabilization of the bilipid layer of endothelial cell membranes, disrupting their functional activity, causing electrical imbalance [20]. Oxidative stress causes damage to the vascular wall and endothelial dysfunction [21].…”

Section: Discussionmentioning

confidence: 99%

Morphological Changes of Periodontal Components Under Experimental Lipopolysaccharide Periodontitis Combined With Hyperthyroidism

et al. 2022

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The aim: Investigate structural changes in the tissues of the periodontal complex under the condition of experimental lipopolysaccharide periodontitis combined with hyper¬thyroidism. Materials and methods: The studies were performed on adult white male rats, which simulated periodontitis combined with hyperthyroidism. Periodontal tissues were subjected to morphological examination on the 22nd day of the experiment. Collection of material for microscopic examinations was performed according to the generally accepted method; histological specimens were studied using a light optical microscope. Results: Morphological studies of the components of the periodontal complex of experimental animals with experimental periodontitis established the reorganization of its structural elements. Damage to the epithelium in the area of attachment of the circular ligament and erosive-ulcerative changes of the gums led to a deepening of the gingival sulcus with the formation of a deep periodontal pocket. Intense hyperkeratosis was observed in the area of the bottom of the periodontal pocket. In the own plate of the mucous membrane of the gums – significant edema, collagen fibers were disorganized, defragmented. There were pronounced destructive-degenerative and inflammatory changes of the epithelial and own plates of all areas of the gums and periodontium, damage to the nuclei and cytoplasm of keratinocytes, fibroblasts, and leukocytes. Conclusions: Experimental periodontitis combined with hyperthyroidism is accompanied by pronounced signs of destructive and inflammatory changes in the soft and dense tissues of the periodontal complex, as well as disruption of stromal-vascular interactions, which progress from reversible to irreversible disruption of periodontal connective tissue.

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“…The theory of the specific microbial composition of the plaque is that only a specific plaque composition is pathogenic, and its pathogenicity is associated with the presence or increase in the plaque composition of only certain microorganisms. The author of this theory is also W. Loesche, he proclaimed it on the basis of methods of isolating specific microorganisms in the composition of dental plaque ( 27 ).…”

Section: Introductionmentioning

confidence: 99%

The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues

Demkovych,

Kalashnikov,

Hasiuk

et al. 2023

Front. Oral. Health

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An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues. Most bacteria produce chain fatty acids that inhibit chemotaxis of leukocytes and phagocytes. Anaerobes and spirochetes secrete a number of substances (propionic acid and indole) that are extremely toxic to most tissues. Inflammation in the periodontal tissues is caused by the microbiota of the dental plaque biofilm. As periodontitis develops, an increase in the number of P. gingivalis, P. intermedia and T. forsythia was found in it, more than 100 times. Therefore, the given data prove that in the development and course of the inflammatory process in the periodontal tissues, complex dysbiotic and tissue-cellular interactions are involved, the dynamic balance of which depends on its outcome.

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The Intensity of Chronic Catarrhal Gingivitis in Children Depending on the Age

Cited by 15 publications

References 4 publications

Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis

Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis

Morphological Changes of Periodontal Components Under Experimental Lipopolysaccharide Periodontitis Combined With Hyperthyroidism

The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues

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