The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat

Marı́n, Carmen; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Gomez, Purificación; Rodríguez, Fernando Rodríguez; Yubero‐Serrano, Elena M.; García‐Rios, Antonio; Camargo, Antonio; Pérez‐Jiménez, Francisco

doi:10.1002/mnfr.201000235

Cited by 17 publications

(12 citation statements)

References 39 publications

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“…Individuals with the rs1522813 A-allele, which is the risk allele for type 2 diabetes, had a higher reversion rate of the MetS by choosing a high-fat diet compared with those without the A-allele. This is consistent with some previous results that the risk alleles of the genetic variants were associated with greater beneficial effects of diet interventions (18,27). The potential mechanisms underlying these findings remain to be investigated.…”

Section: Discussionsupporting

confidence: 93%

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention

Qi¹,

Xu²,

H³

et al. 2013

Diabetes Care

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OBJECTIVEGenetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial.RESEARCH DESIGN AND METHODSTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake from baseline) varying in macronutrient contents for 2 years. We compared MetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers).RESULTSAmong rs1522813 A-allele carriers, the reversion rates of the MetS were higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groups was observed among noncarriers (P = 0.27). The genetic modulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95% CI 1.25–6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36–1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status.CONCLUSIONSOur data suggest that high-fat weight-loss diets might be more effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.

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Section: Discussionsupporting

confidence: 93%

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention

Qi¹,

Xu²,

H³

et al. 2013

Diabetes Care

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“…Importantly, we observed results in the opposite direction for men, whereas women (61%) and men (39%) were examined together in the POUNDS LOST trial. The interaction between another genetic variation in IRS1 (G972R; rs1801278) and relative intakes of carbohydrates and fat was also suggested in a smaller trial (n = 59) (22). It is possible that the different observations among women and men in our study occurred because of biological differences, such as concentrations of sex hormones, which may influence the importance of genetic predisposition as well as optimal carbohydrate and fat intakes with regard to macronutrient metabolism and prevention of diabetes development.…”

Section: Discussionmentioning

confidence: 73%

Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes

Ericson¹,

Rukh²,

Stojkovic³

et al. 2013

The American Journal of Clinical Nutrition

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“…Several other previous studies also reported that individuals carrying risk alleles exhibited greater improvement of respective traits than did noncarriers after diet interventions (62)(63)(64)(65). One may argue that this may reflect baseline weight difference for different genotypes: heavier people (the risk allele carriers) tend to lose more weight.…”

Section: Discussionmentioning

confidence: 90%

FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis

Xiang

Pan

et al. 2016

The American Journal of Clinical Nutrition

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Background: Studies have suggested that the fat mass and obesityassociated (FTO) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions, but results are inconsistent. Objective: We aimed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions. Design: A search of English-language articles in the PubMed and Embase databases (through 30 April 2015) was performed. Eligible studies were diet/lifestyle weight-loss intervention studies conducted in adults that reported changes in body weight or body mass index (BMI) by the FTO variant rs9939609 (or its proxy). Differences in weight loss between FTO genotypes across studies were pooled with the use of fixed-effect models. Results: A meta-analysis of 10 studies (comprising 6951 participants) that reported the results of additive genetic models showed that individuals with the FTO TA genotype and AA genotype (those with the obesity-predisposing A allele) had 0.18-kg (95% CI: 20.09-, 0.45-kg; P = 0.19; NS) and 0.44-kg (95% CI: 0.09-, 0.79-kg; P = 0.015) greater weight loss, respectively, than those with the TT genotype. A metaanalysis of 14 studies (comprising 7700 participants) that reported the results of dominant genetic models indicated a 0.20-kg (20.43-, 0.04-kg) greater weight loss in the TA/AA genotype than in the TT genotype (P = 0.10). In addition, differences in weight loss between the AA genotype and TT genotype were significant in studies with a diet intervention only, adjustment for baseline BMI or body weight, and several other subgroups. However, the relatively small number of studies limited these stratified analyses, and there was no statistically significant difference between subgroups. Conclusions: This meta-analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers. Our data provide evidence for genetic variability in response to diet/lifestyle interventions on weight loss, although clinical applications of these findings need further investigations.

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The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat

Abstract: Insulin sensitivity increased in GR subjects for the G972R polymorphism at the insulin receptor substrate 1 gene locus, after intake of a CHO diet. Increased knowledge of how these and other genes influence insulin sensitivity should increase the understanding of personalized nutrition.

Cited by 17 publications

References 39 publications

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention

Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes

FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis

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