The innovative applications of therapeutic nanostructures in dentistry

Elkassas, Dina; Arafa, Abla

doi:10.1016/j.nano.2017.01.018

Cited by 62 publications

(42 citation statements)

References 185 publications

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“…Although some literature reviews have focused on the incorporation of nanoparticles into dental materials, they have only evaluated the addition of nanoparticles to a specific material or studied a single type of nanoparticle. Elkassas et al [84] summarized the current state of nanotechnology and provided some indications of the potential involvement of nanotechnology in preventive and adhesive dentistry. Allaker et al [17] introduced the possibility of controlling oral infections through the use of nanoparticles, while Noronha et al [85] examined the different antibacterial uses of silver nanoparticles in composites, explaining their mechanism of action and their most important toxicological aspects.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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Background and Objectives: Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. Materials and Methods: A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. Results: A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value < 0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. Conclusions: The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO2 nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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“…Porous structures may be used as temporary scaffolds for newly formed osseous tissue. In dentistry, HA is a component of dental materials such as dental cements and toothpastes [7]. Moreover, it has further uses in polymer/ceramic bone composite materials, not only as a bioactive material but also as a provider of desirable mechanical properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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“…Hence, the present review focuses on the characteristics of various metal and polymerbased nano-materials employed in adhesive and restorative dentistry, acrylic resins, periodontology, tissue engineering, endodontics, and implant dentistry. [94][95][96] 6.1. Nano-materials for preventive dentistry Teeth function in the dynamic environment of the oral cavity, wherein it is a big challenge to prevent tooth decay.…”

Section: Dental Applications Of Nanomaterialsmentioning

confidence: 99%