Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

Abstract

Background and Objectives: Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. Materials and Methods: A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. Results: A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value < 0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. Conclusions: The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO2 nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols.

Novel Strategy to Combat Antibiotic Resistance: A Sight into the Combination of CRISPR/Cas9 and Nanoparticles

“…Transmission electron microscopy (TEM) results revealed that the micelles can penetrate and then destroy the bacterial cell membrane, leading to cell lysis [ 77 ]. Due to their prominent bactericidal properties, NPs were also applied in the coating of human implantable devices, wound dressings, bone cement, and dental materials [ 77 , 78 , 79 , 80 , 81 ].…”

Physicochemical and Mechanical Properties of Bis-GMA/TEGDMA Dental Composite Resins Enriched with Quaternary Ammonium Polyethylenimine Nanoparticles

“…Several low molecular weight inorganic and organic substances have been successfully added to commercial dental restorative composites to achieve materials with antimicrobial activity. Zinc oxide [9,12,13], titanium dioxide [14,15], calcium phosphate [16,17], gold, and silver [18,19] are the most popular examples of the first group. The latter group is represented by antibiotics [20], chlorhexidine [9,21,22], furanone, ursolic acid, benzalkonium chloride, triclosan, and methacryloyloxydodecyl pyridinium bromide [9]; however, toxic responses of tissues adjacent to the reconstructions modified with these substances are often reported [12][13][14][15][16][17][18][19][20][21][22].…”

“…Zinc oxide [9,12,13], titanium dioxide [14,15], calcium phosphate [16,17], gold, and silver [18,19] are the most popular examples of the first group. The latter group is represented by antibiotics [20], chlorhexidine [9,21,22], furanone, ursolic acid, benzalkonium chloride, triclosan, and methacryloyloxydodecyl pyridinium bromide [9]; however, toxic responses of tissues adjacent to the reconstructions modified with these substances are often reported [12][13][14][15][16][17][18][19][20][21][22]. chloride, triclosan, and methacryloyloxydodecyl pyridinium bromide [9]; however, toxic responses of tissues adjacent to the reconstructions modified with these substances are often reported [12][13][14][15][16][17][18][19][20][21][22].…”

Effect of Incorporation of Silver Nanoparticles on the Tensile Bond Strength of a Long term Soft Denture Liner

“…40 Although sometimes recalled as permanent liners, 40 the use of any dental restorative material suffers an inherent problem of aging that develops over time. 41 Thermocycling is conventionally performed for fast thermal aging and simulation of thermal conditions in the oral cavity. 42 The effect of thermocycling on physical properties of soft liners such as tensile and shear bond strength has been evaluated in previous studies and nearly all have agreed on its negative effect.…”