The Injection Treatment of Stress Incontinence

Murless, Bryan C.

doi:10.1111/j.1471-0528.1938.tb12430.x

Cited by 142 publications

(43 citation statements)

References 2 publications

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“…In 1938, Murless [1] described the injection of a scle rosing agent (sodium morrhuate) into the anterior vaginal wall of incontinent women to trigger an inflammatory reaction that would compress an incompetent urethra and produce temporary urinary continence. Since then, a vari However, Politano [6] in 1982 popularised the use of Teflon for the treatment of stress incontinence with a suc cess rate of over 75%.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Correction of Intractable Stress Incontinence with Silicone Micro-Implants

et al. 1997

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Section: Introductionmentioning

confidence: 99%

Endoscopic Correction of Intractable Stress Incontinence with Silicone Micro-Implants

et al. 1997

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“…Periurethral injections of sclerosing agents (paraffin, dondren) have been used to treat incontinence since 1938. 8 In the 1970s, polytetrafluoroethylene was used with initial success, but migration of particles to distant sites (eg lungs, brain) raised concerns. 9,10 Collagen was used in the early 1980s, but problems included allergic reactions and absorption over time.…”

Section: Introductionmentioning

confidence: 99%

The treatment of male stress urinary incontinence with polydimethylsiloxane in compliant bladders following spinal cord injury

Hamid

Arya²,

Khastgir

et al. 2003

Spinal Cord

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Study design: Retrospective analysis. Objectives: To evaluate the safety and efficacy of polydimethylsiloxane (PDS, Macroplastiquet) submucosal injections, in the treatment of male genuine stress urinary incontinence secondary to spinal cord injury (SCI). Setting: London Spinal Injuries Unit, Stanmore, UK and Institute of Urology and Nephrology, London, UK. Patients and methods: A retrospective analysis identified 14 patients treated with PDS for stress urinary incontinence secondary to SCI between 1997 and 2001. A single surgeon at a specialist spinal injuries unit managed all patients. A total of 13 patients had suffered a traumatic SCI (T11:n ¼ 2; T12:n ¼ 5; L1:n ¼ 5; L2:n ¼ 1), while one developed stress incontinence after spinal surgery. The mean age was 41 years (range 26-69 years) and the mean duration of injury was 9.6 years (range 1.5-48 years). The preoperative investigations included video cystometrogram (VCMG) confirming the presence of urodynamically proven stress incontinence without evidence of urge incontinence. Complete cure was defined as a cessation of pad usage with no evidence of leakage on VCMG. Incomplete cure with improvement was defined as a 450% reduction in the number of pads used, with incontinence present on VCMG. Results: The follow-up ranged from 12 to 58 months (mean 34.7 months). Five patients (36%) reported complete success, confirmed by VCMG. Three patients (21%) reported improvement with 450% reduction in the use of pads. The procedure failed completely in six patients (43%). No immediate or late complications were noted with the procedure. Conclusions: The use of PDS is a safe and minimally invasive treatment for genuine stress urinary incontinence in males following SCI with a stable compliant bladder. We achieved complete cure in 36% of our patients with confirmation on VCMG. A further 21% reported greater than 50% reduction in usage of pads; however, on VCMG stress incontinence was demonstrated in these patients. We suggest that PDS can be used as the first line of treatment in this difficult group of patients with complex problems.

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“…In 1938, Murless [8] was the first to describe the injection of a sclerotizing substance into the anterior vaginal wall, with a success rate of 60%. From numerous studies on the efficacy of periurethral injections for the treatment of SUI, we find that the reported improvement rate varies from 40 to 90% with a success rate of about 50%.…”

Section: Agents Used For Periurethral Injectionsmentioning

confidence: 99%

Injection Therapy for the Treatment of Stress Urinary Incontinence in Women

Meschìa

Pifarotti

Gattei

et al. 2002

Gynecol Obstet Invest

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The purpose of this review is to summarize the results of reports on injectable agents in the treatment of female stress urinary incontinence. Six agents were reviewed: Teflon; autologous fat; collagen; silicone microparticles; silicone microballoons, and pyrolytic carbon. Collagen was the most frequently reported agent and yielded a 1-year cure/improvement rate of 60–80%, but results worsened significantly with longer follow-up. Teflon has been used longer in the treatment of stress incontinence, but low long- and short-term success rates and reported complications such as particle migration have prevented its widespread acceptance. Autologous fat has been suggested as a natural injectable but its success rate has been disappointing. The injection of silicone microparticles is associated with a long-term success rate of about 70% in patients with intrinsic sphincter deficiency, and it can now be injected more easily without the need of urethroscopy. Silicone microballoons and pyrolytic carbon has recently been introduced into clinical practice with a short-term success rate of about 70%, but longer follow- up is needed. In conclusion, the long-term durability, cost-effectiveness, and some safety issues still have to be addressed by further clinical trials.

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The Injection Treatment of Stress Incontinence

Cited by 142 publications

References 2 publications

Endoscopic Correction of Intractable Stress Incontinence with Silicone Micro-Implants

Endoscopic Correction of Intractable Stress Incontinence with Silicone Micro-Implants

The treatment of male stress urinary incontinence with polydimethylsiloxane in compliant bladders following spinal cord injury

Injection Therapy for the Treatment of Stress Urinary Incontinence in Women

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