Endoscopic Correction of
Intractable Stress Incontinence
with Silicone Micro-Implants

Sheriff, M. K. M.; Foley, Stephen; McFarlane, J.P.; Nauth-Misir, R.; Shah, P.J.R.

doi:10.1159/000480826

Cited by 45 publications

(22 citation statements)

References 16 publications

(23 reference statements)

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“…An alternative explanation is poor procedural technique, but we feel this is unlikely given that our subjective success rate is similar to that in the literature and all surgeons had significant experience with other transurethral agents and Macroplastique prior to commencing the study. Our median reimplantation rate for Macroplastique of 22% is similar to that reported, which ranges from 12% to 35% 10–13 . Our 90% subjective and 81% objective success rates using the pubovaginal sling are consistent with the literature 6,7 but lower than the 100% success rate reported by Sand et al 24 Our voiding dysfunction rate of 20% following the sling is higher than that reported by Sand et al 24 but similar to other authors 20,21 …”

Section: Discussionsupporting

confidence: 90%

“…The short term subjective and patient‐determined success rates we reported for Macroplastique are similar to that in the literature, which ranges from 48% to 74% 10–13 . The 10% objective success rate we reported is very low.…”

Section: Discussionsupporting

confidence: 85%

“…Outcome data were analysed on an intention‐to‐treat basis. Sample size was determined on the basis of a 48% success rate for the Macroplastique 11 and a 90% success rate for the pubovaginal sling, 6 and a two‐sided significance level of α= 0.05 and a study with statistical power of 80%. Using a two‐group continuity corrected χ 2 test, the sample size required in each group to fulfil these specifications was 23.…”

Section: Methodsmentioning

confidence: 99%

“…Macroplastique (Uroplasty, Minneapolis, Minnesota, USA) is a vulcanised silicone microimplant (polydimethylsiloxone) suspended in a povidine gel designed to provide urethral bulking for the treatment of SUI. Initial evaluation of the Macroplastique reported success rates of 48–74% at three months to three years 10–13 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial

Maher

O’Reilly

Dwyer

et al. 2005

BJOG

115

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Objective To compare the pubovaginal sling and transurethral Macroplastique in the treatment of female stress urinary incontinence (SUI) and intrinsic sphincter deficiency (ISD). Design A prospective randomised controlled trial comparing two surgical treatments for SUI and ISD.Setting Tertiary referral urogynaecology unit in Australia.Population Women with SUI and ISD who were suitable for either surgical technique.Methods Forty-five women with SUI and ISD were randomly allocated the pubovaginal sling (n ¼ 22) or transurethral Macroplastique (n ¼ 23). Subjective and objective success rates, patient satisfaction and cost measurements at six months and one year following surgery were the primary outcome measures. A telephone questionnaire survey was performed at a mean follow up period of 62 months (43 -71). Main outcome measure Comparison of success rates, complications and costs.Results The symptomatic and patient satisfaction success rates were similar following the sling and Macroplastique with the objective success rate being significantly greater (P < 0.001) following the sling (81% vs 9%). Macroplastique had significantly lower morbidity but was more expensive than the sling (P < 0.001). Response rate at 62 months follow up was 60% in both groups with the sling group reporting better continence success (69% vs 21%) and satisfaction rates (69% vs 29%, P ¼ 0.057). Conclusions The pubovaginal sling was more effective and economical than transurethral Macroplastique for the treatment of SUI and ISD. However, transurethral Macroplastique remains an appropriate treatment in selected cases of SUI and ISD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial

Maher

O’Reilly

Dwyer

et al. 2005

BJOG

115

View full text Add to dashboard Cite

show abstract

“…Success rates vary with material used but deteriorate over time to about 50% at 2 years. 40 The procedure has low morbidity and may have a role when other procedures have failed or when the woman is unfit for surgery. There are many materials available for use.…”

Section: Periurethral Bulking Agentsmentioning

confidence: 99%

Evidence‐based management of stress urinary incontinence

Johnson

Slack

2005

The Obstetric & Gynaecologis

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Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

et al. 2003

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The objective is to study the tissue reaction of the paralyzed vocal cord in response to the injection of particulate plastics in a rabbit model. Forty-five New Zealand rabbits with surgical vocal-fold paralysis were used in the study. Histologic reactions of the larynx and the regional lymph nodes were analyzed by a single blinded pathologist at 6 weeks and 6 months after a vocal-cord injection of Teflon or of silicone elastomer. Macroscopic studies of the liver, lungs, spleen, kidney, and brain were performed. The histological study showed a greater proportion of chronic granulomatous inflammation in animals injected with silicone than in those injected with Teflon. The immunohistochemical study showed a higher degree of phagocytosis of Teflon particles than of the silicone particles. The silicone group presented a more severe fibrous reaction than the Teflon group, but the difference was not significant. No migration particles were found. It is concluded that silicone, having a greater viscosity than Teflon because of the size of its particles, induces more fibrosis and a larger proportion of foreign giant cells in the host. Due to this histological reaction, silicone particles present greater anchorage and stability.

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Endoscopic Correction of Intractable Stress Incontinence with Silicone Micro-Implants

Cited by 45 publications

References 16 publications

Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial

Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial

Evidence‐based management of stress urinary incontinence

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

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