The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals

Tasca, Karen Ingrid; Caleffi, Juliana Trindade; Corrêa, Camila Renata; Gatto, Mariana; Camargo, Caio Cavassan de; Mendes, Mônica Bannwart; Golim, Márjorie de Assis; Biasin, Mara; Souza, Lenice do Rosário de

doi:10.1155/2016/2909576

Cited by 8 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, as demonstrated by our own group in a recent research employing the same cohort of the present study, although there was no difference in the levels of some inflammatory and anti-inflammatory cytokines, there was an increased level of C-reactive protein (CRP) and triglycerides already in the first months of therapy [28]. These markers may also be associated with increased oxidative stress described here in the same period.…”

Section: Discussionsupporting

confidence: 75%

Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Tasca

Caleffi

Corrêa

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation. We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results. Results showed a decrease in TAC, retinol, α-tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1. These changes were more evident in G2 subjects. Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1. Conclusion. The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500 cells/mm3 showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases.

show abstract

Section: Discussionsupporting

confidence: 75%

Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Tasca

Caleffi

Corrêa

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, Sprenger et al (2017), in accordance with our findings, demonstrated in a single-center prospective cohort study that HIV-1 patients had increased accumulation of tissue AGEs in the skin in comparison with healthy age-matched controls, which could represent an independent predictor of CVD in these patients over a 5-year follow-up period (Sprenger et al, 2017). On the other hand, Tasca et al (2016) showed that after 6 months of the introduction of cART, the plasma levels of AGEs in PLWH decreased. This discrepant result from ours could be due to the shorter period that patients were under cART (6–12 months vs. ∼ 15 years in our study), suggesting that prolonged cART might play a key role in circulating AGEs increasing.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have so far investigated the role of AGEs in HIV infection and they showed controversial results. Recently, Sprenger et al (2017) demonstrated that HIV-1 patients had increased accumulation of AGEs in the skin in comparison with healthy individuals, while Tasca et al (2016) showed decreased AGE levels after 6 months of cART introduction. Therefore studies which aim to address the participation of AGE in physiopathology of HIV-infection and cART treatment are necessary to dissect the mechanisms involved in metabolic complications associated to continuous cART.…”

Section: Introductionmentioning

confidence: 99%

Influence of Physical Exercise on Advanced Glycation End Products Levels in Patients Living With the Human Immunodeficiency Virus

et al. 2018

View full text Add to dashboard Cite

Introduction: Combined antiretroviral therapy (cART) used to treat acquired immunodeficiency virus (HIV) induces a number of adverse effects, such as insulin resistance and dyslipidemia, which ultimately increases the cardiovascular risk. Advanced glycation end products (AGEs) have been implicated in the etiology of cardiovascular diseases, diabetes and other chronic diseases. It is known that physical exercise improves the lipid profile, insulin resistance and reduces the risk of cardiovascular diseases. However, the impact of physical exercise on AGE levels in HIV-infected patients has not been so far investigated. Therefore, this study compared AGEs levels in people with and without HIV and verified the effect of physical training on serum AGE levels.Methods: Participants were initially assigned into three groups: healthy control (CTL, n = 35), physically inactive HIV-infected (In-HIV, n = 33) and physically active HIV-infected (Ac-HIV, n = 19). The In-HIV group underwent physical training for 3 months, consisting of 60-min sessions of multimodal supervised exercise (aerobic, resistance and flexibility) with moderate intensity (50–80% heart rate reserve), performed 3 times/week. AGEs were measured in serum by fluorescence spectrometry.Results: At baseline, serum AGEs fluorescence level was significantly higher in inactive HIV-patients when compared to controls or active HIV-patients (In-HIV: 0.93 ± 0.08 vs. controls: 0.68 ± 0.13 and Ac-HIV: 0.59 ± 0.04 A.U.; P < 0.001). Triglycerides were also higher in In-HIV than CTL (182.8 ± 102 vs. 132.8 ± 52.3 mg/dL; P < 0.05). Waist circumference was lower in Ac-HIV, compared to In-HIV and controls (83.9 ± 10.4 vs. 92.9 ± 13.5 and 98.3 ± 12.4, respectively; P < 0.05). Body mass, fasting blood glucose, LDL, HDL, and total cholesterol were similar between groups. After training, AGE levels decreased (Baseline: 0.93 ± 0.08 vs. 3 months follow-up: 0.59 ± 0.04 AU; P < 0.001), no further difference being detected vs. CTL or Ac-HIV. Conclusion: HIV-infected patients under cART exhibited elevated AGEs levels compared to healthy individuals and physically active patients. Short-term aerobic training of moderate intensity counteracted this condition.

show abstract

“…In this study, there was no difference in CRP levels between the groups (Table 1), whose means were within normal limits. However, in a previous study carried out by our group (Tasca et al, 2016), there was an increase in CRP in the first six months after the introduction of ART. Considering these two findings, we suggest that a transient alteration of this marker may occur in the initial months of ART, with later normalization.…”

Section: Metabolic Variablesmentioning

confidence: 52%

Contributory role of ART in the development of non-AIDS comorbidities in asymptomatic PLWHA

Tasca¹,

Vidal²,

Manfio³

et al. 2021

JAB

Self Cite

View full text Add to dashboard Cite

Background: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/AIDS (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n = 21), ART-naïve individuals; G2 (n = 17), <2 years; G3 (n = 40), 2-10 years; and G4 (n = 16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p < 0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p = 0.003). A decrease in glomerular filtration rates occurred in 20% of patients, which was also more significant in G3 and G4 (p = 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p = 0.04 and BAP, p = 0.005) and osteocalcin (p = 0.005), in addition to higher vitamin-D concentrations (p = 0.04). Conclusions: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy.

show abstract

The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals

Cited by 8 publications

References 53 publications

Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Influence of Physical Exercise on Advanced Glycation End Products Levels in Patients Living With the Human Immunodeficiency Virus

Contributory role of ART in the development of non-AIDS comorbidities in asymptomatic PLWHA

Contact Info

Product

Resources

About