The initial experience of the upper abdominal CT angiography using low-concentration contrast medium on dual energy spectral CT

Xin, Lei; Yang, Xiaotang; Huang, Ning; Xiang-ke, DU; Zhang, Jianxin; Wang, Yanyan; Hou, Lina; Gao, Jinfang

doi:10.1007/s00261-015-0462-4

Cited by 33 publications

(13 citation statements)

References 12 publications

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“…Therefore, minimizing radiation dose is critically important. The mean CTDIvol (9.89 mGy) of the enteric phase in our study was smaller than that of previous DECT studies (14.2–15.0 mGy) and of previous single-energy CT studies (13.1–16.2 mGy) ( 32 33 34 35 ). We believe that such low radiation exposure in our study is mainly due to the unique hardware design of the dual-layer spectral CT scanner.…”

Section: Discussioncontrasting

confidence: 87%

Iodine Quantification on Spectral Detector-Based Dual-Energy CT Enterography: Correlation with Crohn's Disease Activity Index and External Validation

Kim

Ryu

et al. 2018

Korean J Radiol

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ObjectiveTo correlate CT parameters on detector-based dual-energy CT enterography (DECTE) with Crohn's disease activity index (CDAI) and externally validate quantitative CT parameters.Materials and MethodsThirty-nine patients with CD were retrospectively enrolled. Two radiologists reviewed DECTE images by consensus for qualitative and quantitative CT features. CT attenuation and iodine concentration for the diseased bowel were also measured. Univariate statistical tests were used to evaluate whether there was a significant difference in CTE features between remission and active groups, on the basis of the CDAI score. Pearson's correlation test and multiple linear regression analyses were used to assess the correlation between quantitative CT parameters and CDAI. For external validation, an additional 33 consecutive patients were recruited. The correlation and concordance rate were calculated between real and estimated CDAI.ResultsThere were significant differences between remission and active groups in the bowel enhancement pattern, subjective degree of enhancement, mesenteric fat infiltration, comb sign, and obstruction (p < 0.05). Significant correlations were found between CDAI and quantitative CT parameters, including number of lesions (correlation coefficient, r = 0.573), bowel wall thickness (r = 0.477), iodine concentration (r = 0.744), and relative degree of enhancement (r = 0.541; p < 0.05). Iodine concentration remained the sole independent variable associated with CDAI in multivariate analysis (p = 0.001). The linear regression equation for CDAI (y) and iodine concentration (x) was y = 53.549x + 55.111. For validation patients, a significant correlation (r = 0.925; p < 0.001) and high concordance rate (87.9%, 29/33) were observed between real and estimated CDAIs.ConclusionIodine concentration, measured on detector-based DECTE, represents a convenient and reproducible biomarker to monitor disease activity in CD.

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Section: Discussioncontrasting

confidence: 87%

Iodine Quantification on Spectral Detector-Based Dual-Energy CT Enterography: Correlation with Crohn's Disease Activity Index and External Validation

Kim

Ryu

et al. 2018

Korean J Radiol

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“…Compared with group B, CTDI vol and DLP in group A were decreased by 46% and 35%, respectively. Xin et al . performed upper abdominal CTA on patients with medium BMI using spectral CT scanning with low‐concentration contrast medium and compared the results with results obtained by conventional scanning; the former method was superior to the latter in image quality while reducing both radiation dose and contrast medium dose.…”

Section: Discussionmentioning

confidence: 99%

“…Because patients with high BMI and waist circumference were scanned in this study, the total volume of contrast medium for each patient enrolled in this study would be ≥100 mL if calculated using the recommended protocol of 1.5 mL/kg (350 mg I/mL) . To avoid an overdose of contrast medium, the lowest volume (100 mL) was used in both the groups, and the contrast medium was injected at a flow rate of 5 mL/s to ensure an appropriate concentration of the contrast medium in vessels according to our previous experience…”

Section: Discussionmentioning

confidence: 99%

Feasibility of spectral imaging with low-concentration contrast medium in abdominal CT angiography of obese patients

Liu

Лю

et al. 2016

Int J Clin Pract

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“…In the gemstone CT spectral scanning, these mixed energy images (QC images) are to obtain a quick view of the scanning effect and range and for comparison with the monochromatic spectral images rather than for clinical diagnosis. Radiologists evaluated the images blindly using the same window width and position with a five-point scale ( 9 10 11 ): 5, excellent vessel signal intensity with very sharp edge of vessels; 4, good signal intensity with sharp edge of vessels; 3, fair signal intensity with fairly sharp edge of vessels; 2, bad signal intensity with unclear vessel edge; and 1, worse signal intensity with blurred edge of vessels.…”

Section: Methodsmentioning

confidence: 99%

Optimal Monochromatic Imaging of Spectral Computed Tomography Potentially Improves the Quality of Hepatic Vascular Imaging

Yin

Gao

et al. 2018

Korean J Radiol

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ObjectiveTo investigate the efficiency of spectral computed tomography (CT) optimal monochromatic images in improving imaging quality of liver vessels.Materials and MethodsThe imaging data of 35 patients with abdominal CT angiography were retrospectively analyzed. Hepatic arteries, portal veins, and hepatic veins were reconstructed with mixed energy (quality check, QC), 70 keV and optimal monochromatic mode. Comparative parameters were analyzed including CT value, image noise (IN), contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and subjective qualitative analysis.ResultsThe optimal monochromatic value for assessment of the common hepatic artery, portal vein, and hepatic vein ranged between 49 keV and 53 keV, with a mean of 51 keV. There were statistically significant differences (p < 0.001) among the optimal monochromatic, 70 keV and QC images with regards to the hepatic vascular CT value, IN, CNR, SNR, and subjective qualitative score. CNR of the common hepatic artery in the optimal monochromatic, 70 keV and QC groups was 24.6 ± 10.9, 18.1 ± 8.3, and 11.6 ± 4.6, respectively (p < 0.001) with subjective scores of 4.7 ± 0.2, 4.0 ± 0.3, and 3.6 ± 0.4, respectively (p < 0.001). CNR of the hepatic portal vein was 6.9 ± 2.7, 4.3 ± 1.9, and 3.0 ± 2.1, respectively (p < 0.001) with subjective scores of 4.5 ± 0.3, 3.9 ± 0.4, and 3.3 ± 0.3, respectively (p < 0.001). CNR of the hepatic vein was 5.7 ± 2.3, 4.2 ± 1.9, and 2.7 ± 1.4, respectively with subjective scores of 4.3 ± 0.3, 3.8 ± 0.4, and 3.2 ± 0.3, respectively (p < 0.001).ConclusionOptimal monochromatic images can lead to improvement in the imaging parameters and optimization of the image quality of the common hepatic artery, hepatic portal vein and hepatic vein compared with conventional mixed kV and with 70 keV datasets.

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The initial experience of the upper abdominal CT angiography using low-concentration contrast medium on dual energy spectral CT

Abstract: With 28% contrast medium reduction and reduced radiation dose, CT angiography using spectral imaging and lower concentration contrast agent provided better image quality than conventional CTA.

Cited by 33 publications

References 12 publications

Iodine Quantification on Spectral Detector-Based Dual-Energy CT Enterography: Correlation with Crohn's Disease Activity Index and External Validation

Iodine Quantification on Spectral Detector-Based Dual-Energy CT Enterography: Correlation with Crohn's Disease Activity Index and External Validation

Feasibility of spectral imaging with low-concentration contrast medium in abdominal CT angiography of obese patients

Optimal Monochromatic Imaging of Spectral Computed Tomography Potentially Improves the Quality of Hepatic Vascular Imaging

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