The inhibitory mechanisms of glucose and carbon dioxide on the biosyntheses of penicillins and cephalosporins

Filamentous fungi are important organisms industrially and continue to attract research interest as microbiologists attempt to overcome the problems associated with their behavior in submerged culture. This review critically examines the literature describing these problems and where available suggests possible solutions to them. The influence of the chemical and physical environment on culture morphology, the process engineering challenges presented by different fungal morphologies, and the relationship between fungal morphology and metabolite production are all discussed.

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The inhibitory mechanisms of glucose and carbon dioxide on the biosyntheses of penicillins and cephalosporins

Cited by 3 publications

References 51 publications

Metagenomics and metatranscriptomics analyses of antibiotic synthesis in activated sludge

Metagenomics and metatranscriptomics analyses of antibiotic synthesis in activated sludge

Dissolved carbon dioxide effects on growth, nutrient consumption, penicillin synthesis and morphology in batch cultures of Penicillium chrysogenum

Growth of Filamentous Fungi in Submerged Culture: Problems and Possible Solutions

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