The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling

Seo, Mi Sook; Lee, Yeon Joo; Hwang, Jang Yeon; Kim, Kui-Jin; Lee, Boo-Yong

doi:10.1016/j.jnutbio.2015.06.005

Cited by 154 publications

(119 citation statements)

References 56 publications

(61 reference statements)

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“…These results are in line with the reduction of cytokine production (TNF-α and IL-1β) in the soleus muscle and with the chemoattractive role of TNF-α and IL-1β over neutrophils [1,2,33]. For instance, TNF-α activates both neutrophils and macrophages [1,30,34]. Thus, inhibiting TNF-α and IL-1β production reduces the recruitment and activation of these cells.…”

Section: Discussionsupporting

confidence: 68%

“…The intense acute swimming-induced muscle hyperalgesia depends on the balance of pro-inflammatory and anti-inflammatory cytokines [1,2,21]. There is evidence that quercetin can induce IL-10 production and this mechanism may explain at least in part its anti-inflammatory effects [30,31]. The present observation that quercetin inhibited intense acute swimming-induced IL-10 production was unexpected.…”

Section: Discussionmentioning

confidence: 49%

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Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

et al. 2016

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The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 49%

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

et al. 2016

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“…Insulin resistance is believed to be the result of chronic low-grade inflammation [17], which activated MAPK kinases, leading to phosphorylation of ERK and P38MAPK and causing insulin resistance of adipocytes [17][18][19][20]. In the present study, baicalein significantly reversed the upregulation of pP38MAPK as well as pERK in the adipocytes of diet-induced obese mice.…”

Section: Discussionsupporting

confidence: 56%

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Wen

Fang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Although baicalein has been shown to increase insulin sensitivity in liver of mice, there is no literature available about the effect of baicalein on glucose transporter 4 (GLUT4) translocation from intracellular membrane pools to plasma membranes in adipocytes of diet-induced obese mice. Methods: In the present study, the obese model was induced in mice fed a high fat diet (20% carbohydrates, 21% protein and 59% fat) for 16 weeks. The diet-induced obese mice were given 20mg/kg baicalein intraperitoneally (i.p.) once a day for 21 days. The plasma insulin was measured by enzyme-linked immunosorbent assay. Fasting blood glucose and insulin resistance indexes were measured by glucose tolerance test (GTT). The expression levels of PGC-1α, UCP1, GLUT4, PPARγ, pP38MAPK, pERK and pAKT in adipocytes were determined by quantitative real-time polymerase chain reaction and western blotting. Results: The present findings showed that administration of baicalein decreased pP38MAPK, pERK and PPARγ levels, but enhanced pAKT, PGC-1α and UCP1 contents as well as GLUT4 expression in adipocytes, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in diet-induced obese mice. Moreover, baicalein treatment increased GLUT4 concentration in plasma membranes of adipocytes, i.e. baicalein may prevent insulin resistance through the GLUT4 translocation from intracellular membrane compartments to plasma membranes in adipocytes. Conclusion: These results suggest that baicalein is a powerful and promising agent for treatment of obesity and insulin resistance via Akt/GLUT4 pathway.

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“…The role of polyphenols in the diet has also been widely studied for antioxidant, anticarcinogenic, anti-inflammatory, and antihypercholesterolemic activities as well as cardio-and neuroprotective actions. The mechanisms behind flavonoid-derived effects on disease include the inhibition of numerous cellular pathways such as mitogen-activated protein kinase (MAPK) (9) and NF-B (10,11) as well as the inhibition of Src, phosphatidylinositol 3-kinase (PI3K), PDK1, and Akt (10). Cellular processes that are inhibited or modulated by flavonoids include oxidative stress (reviewed in reference 12), cathepsin activity (13,14), and autophagy induction (reviewed in reference 15).…”

mentioning

confidence: 99%

Prophylactic Efficacy of Quercetin 3-β- O - d -Glucoside against Ebola Virus Infection

Qiu

Kroeker

et al. 2016

Antimicrob Agents Chemother

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Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no approved therapies or vaccines, many promising candidates are undergoing clinical trials, and several have had success in promoting recovery from Ebola. However, these prophylactics and therapeutics have been designed and tested only against the same species of Ebola virus as the one causing the current outbreak. Future outbreaks involving other species would require reformulation and possibly redevelopment. Therefore, a broad-spectrum alternative is highly desirable. We have found that a flavonoid derivative called quercetin 3-␤-O-D-glucoside (Q3G) has the ability to protect mice from Ebola even when given as little as 30 min prior to infection. Furthermore, we have demonstrated that this compound targets the early steps of viral entry. Most promisingly, antiviral activity against two distinct species of Ebola virus was seen. This study serves as a proof of principle that Q3G has potential as a prophylactic against Ebola virus infection.

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The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling

Cited by 154 publications

References 56 publications

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice

Prophylactic Efficacy of Quercetin 3-β- O - d -Glucoside against Ebola Virus Infection

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