Prophylactic Efficacy of Quercetin 3-β-
            <i>O</i>
            -
            <scp>d</scp>
            -Glucoside against Ebola Virus Infection

Qiu, Xiangguo; Kroeker, Andrea; He, Shihua; Kozak, Robert; Audet, Jonathan; Mbikay, Majambu; Chrétien, Michel

doi:10.1128/aac.00307-16

Cited by 80 publications

(65 citation statements)

References 33 publications

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“…Another flavonoid derivative, 3-β-O-d-glucoside, was able to protect mice from Ebola virus infection when given prior to virus challenge. However, the mechanism by which this flavonoid inhibited viral entry is unclear [10].…”

Section: Flavonoids Against Non-picornavirusesmentioning

confidence: 99%

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Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

142

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Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.

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Section: Flavonoids Against Non-picornavirusesmentioning

confidence: 99%

“…Another flavonoid derivative, 3-β-O-D-glucoside, was able to pro when given prior to virus challenge. However, the mechanism by w entry is unclear [10]. In a similar manner, sulfated rutin was shown to block the entr (HIV)-1 without interactions with the host cell membrane.…”

Section: Flavonoids Against Non-picornavirusesmentioning

confidence: 99%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

142

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“…To clarify the matter, it is necessary to develop structure–activity relationship (SAR) studies on the flavonoid. Such SAR studies would broaden our understanding of the mechanisms that contribute to flavonol glucoside antiviral action against medically-important pathogens such as ZIKV and other related mosquito-borne viruses, as well as influenza and Ebola viruses [ 24 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells

Gaudry

Bos

Viranaïcken

et al. 2018

IJMS

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The medical importance of Zika virus (ZIKV) was fully highlighted during the recent epidemics in South Pacific islands and Americas due to ZIKV association with severe damage to fetal brain development and neurological complications in adult patients. A worldwide research effort has been undertaken to identify effective compounds to prevent or treat ZIKV infection. Fruits and vegetables may be sources of compounds with medicinal properties. Flavonoids are one class of plant compounds that emerge as promising antiviral molecules against ZIKV. In the present study, we demonstrated that flavonoid isoquercitrin exerts antiviral activity against African historical and Asian epidemic strains of ZIKV in human hepatoma, epithelial, and neuroblastoma cell lines. Time-of-drug addition assays showed that isoquercitrin acts on ZIKV entry by preventing the internalisation of virus particles into the host cell. Our data also suggest that the glycosylated moiety of isoquercitrin might play a role in the antiviral effect of the flavonoid against ZIKV. Our results highlight the importance of isoquercitrin as a promising natural antiviral compound to prevent ZIKV infection.

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“…Isoquercitrin (ISQ) (a Wnt/β‐catenin pathway inhibitor) was purchased from Sigma Aldrich Pvt. Ltd. and the doses were selected based on previous literature …”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β‐catenin signaling pathway inhibition

et al. 2020

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Diabetic neuropathy is a peripheral nervous system disorder affecting both somatic and autonomic components of nervous system. A growing body of evidence have depicted that high glucose levels can induce activation of the Wnt/β‐catenin pathway, however there are no studies targeting this pathway in DN. The intent of the present study was to investigate the effects of isoquercitrin (ISQ), a Wnt/β‐catenin signaling pathway inhibitor, in diabetic neuropathy. Streptozotocin (50 mg/kg, i.p.) was used to induce diabetes in rats. 6‐week diabetic rats were treated intrathecally with ISQ at 10 and 30 μM doses for 3 days. Furthermore, to confirm the results of the intrathecal study, a 2‐week intraperitoneal treatment of ISQ was given to diabetic rats. After 6 weeks, diabetic rats developed neuropathy which was evident from reduced thermal and mechanical hyperalgesia thresholds and significant deterioration in motor nerve conduction velocity (MNCV), nerve blood flow (NBF). Sciatic nerves of diabetic neuropathy rats showed increased expression of Wnt pathway proteins namely β‐catenin, c‐myc and MMP2. Treatment with ISQ, both intrathecally (10 and 30 μM) and intraperitoneally (10 mg/kg), significantly ameliorated the alterations in behavioral pain thresholds and improved functional parameters in diabetic rats. Moreover, ISQ also downregulated the expression of Wnt/β‐catenin pathway proteins significantly in diabetic rats as compared to vehicle‐treated diabetic rats. Results of the present study suggest the neuroprotective potential of ISQ in the treatment of DN via inhibition of Wnt/β‐catenin signaling pathway.

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Prophylactic Efficacy of Quercetin 3-β- O - d -Glucoside against Ebola Virus Infection

Cited by 80 publications

References 33 publications

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells

Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β‐catenin signaling pathway inhibition

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