The inhibitory effect of the catechin structure on advanced glycation end product formation in alcoholic media

Wu, Qian; Tang, Shimiao; Liang, Zhang; Xiao, Jinsong; Luo, Qing; Chen, Yuanyuan; Zhou, Mengzhou; Feng, Nianjie; Wang, Chao

doi:10.1039/c9fo02887k

Cited by 26 publications

(7 citation statements)

References 41 publications

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“…Among compounds capable of reducing blood glucose levels, phenolic compounds, mainly anthocyanins, and iridoids, should be mentioned [ 54 ]. The conducted studies showed a strong positive correlation between glucosidase inhibitory activity and TPC (R 2 = 0.9899) ( Figure 4 ), which indicates the effect of the synergistic action of several classes of phenolic compounds, such as phenolic acids (e.g., chlorogenic acid, gallic acid) and flavonoids (especially flavonols and flavan-3-ols, which are well-known as good glucose-lowering agents [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

et al. 2022

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As a systemic disease, diabetes mellitus (DM) is characterized by the disruption of many glucose metabolic pathways. Therefore, it seems critical to study new therapies to support treatment to develop therapeutic systems that can operate across a broad metabolic spectrum. The current state of knowledge indicates an essential role of the gut microbiota in the development and course of the disease. Cornus mas fruits have demonstrated a rich biological activity profile and potential for application in the treatment of DM. As part of a preliminary analysis, the activity of four cultivars of Cornus mas fruits was analyzed. The cultivar Wydubieckij was selected as having the highest activity in in vitro conditions for further prebiotic system preparation. The study aimed to develop a unique therapeutic system based, first of all, on the mechanism of α-glucosidase inhibition and the antioxidant effect resulting from the activity of the plant extract used, combined with the prebiotic effect of inulin. The obtained system was characterized in vitro in terms of antioxidant activity and enzyme inhibition capacity, and was then tested on diabetic rats. The study was coupled with an analysis of changes in the intestinal microflora. The system of prebiotic stabilized Cornus mas L. lyophilized extract with inulin offers valuable support for the prophylaxis and treatment of DM.

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Section: Resultsmentioning

confidence: 99%

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

et al. 2022

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“…The differences in inhibitory activity of various PPN conjugates might be due to structural variation and the number of -OH groups in both COS and PPN. CAT might interact with the side chains and form hydrogen bonds with Asp 197 and Asn 298 residues of the active site of the enzyme and may form π-π interactions between stacked, delocalized ring systems of the PPN and the indole ring of Trp 62 in α-amylase [ 46 ]. The higher inhibitory activity of COS-CAT is most probably due to high binding affinity with the active site of the enzyme.…”

Section: Resultsmentioning

confidence: 99%

Chitooligosaccharide Conjugates Prepared Using Several Phenolic Compounds via Ascorbic Acid/H2O2 Free Radical Grafting: Characteristics, Antioxidant, Antidiabetic, and Antimicrobial Activities

Mittal

Singh

Zhang

et al. 2022

Foods

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Chitooligosaccharide (COS)-polyphenol (PPN) conjugates prepared using different PPNs, including gallic, caffeic, and ferulic acids, epigallocatechin gallate, and catechin, at various concentrations were characterized via UV-visible, FTIR, and 1H-NMR spectra and tested for antioxidant, antidiabetic, and antimicrobial activities. Grafting of PPNs with COS was achieved. The highest conjugation efficiency was noticed for COS-catechin (COS-CAT), which was identified to have the highest total phenolic content (TPC) out of all the conjugates (p < 0.05). For antioxidant activities, DPPH and ABTS radical scavenging activities (DPPH-RSA and ABTS-RSA, respectively), oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), and metal chelating activity (MCA) of all the samples were positively correlated with the TPC incorporated. COS-CAT had higher DPPH-RSA, ABTS-RSA, ORAC, and FRAP than COS and all other COS-PPN conjugates (p < 0.05). In addition, COS-CAT also showed the highest antidiabetic activity of the conjugates, as determined by inhibitory activity toward α-amylase, α-glucosidase, and pancreatic lipase (p < 0.05). COS-CAT also had the highest antimicrobial activity against all tested Gram-negative and Gram-positive bacteria (p < 0.05). Overall, grafting of PPNs, especially CAT on COS, significantly enhanced bioactivities, including antioxidant and antimicrobial, which could be used to retard spoilage and enhance shelf-life of various food systems. Moreover, the ability of COS-CAT to inhibit digestive enzymes reflects its preventive effect on diabetes mellitus and its complications.

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“…Glyoxal, a typical α-dicarbonyl compound, is the primary intermediate that forms AGEs in both food processing and gastrointestinal digestion systems (3, 4). LPOPCs were composed of a variety of oligomeric procyanidins, which could be attached to α-dicarbonyl compounds via electrophilic substitution to form adducts (32). In the simulated food processing system, 24.9% of GO was effectively trapped by LPOPCs (Figure 5A).…”

Section: Evaluation Of Go Trapping Capacitymentioning

confidence: 99%

Debate: Could the litchi pericarp oligomeric procyanidins bioconverted by Lactobacillus plantarum increase the inhibitory capacity on advanced glycation end products?

Feng

Tang

et al. 2022

Front. Nutr.

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Lactic acid bacteria (LAB) have already been used as fermentation strains to enhance the antioxidant capacity of polyphenols. Antioxidant capacity is one of the most important factors to inhibit advanced glycation end product (AGE) formation and could LAB increase the inhibitory capacity of procyanidins on AGEs formation? It was surprising that opposite results were obtained both in simulated food processing and gastrointestinal digestion systems. After incubation with Lactobacillus plantarum (L. plantarum), litchi pericarp oligomeric procyanidins (LPOPCs) were bioconverted to several phenolic acids, which increased the antioxidant activity as expected. However, antiglycation ability and trapping carbonyl compounds capacity both weakened and it might be the primary reason for decreasing the inhibitory effect on AGE formation. Furthermore, it was found that LPOPCs incubated with L. plantarum inhibited the activity of digestive enzymes and thus decreased the digestibility of glycated protein. Our study systematically proposed for the first time that procyanidins bioconversion is an effective means to improve the antioxidant activity but has no remarkable promoting effect on AGEs inhibition.

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The inhibitory effect of the catechin structure on advanced glycation end product formation in alcoholic media

Abstract: Catechin has a good inhibitory effect on advanced glycation end product (AGE) formation in alcoholic media, which is generated by Maillard reaction is closely related to diabetes.

Cited by 26 publications

References 41 publications

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

Chitooligosaccharide Conjugates Prepared Using Several Phenolic Compounds via Ascorbic Acid/H2O2 Free Radical Grafting: Characteristics, Antioxidant, Antidiabetic, and Antimicrobial Activities

Debate: Could the litchi pericarp oligomeric procyanidins bioconverted by Lactobacillus plantarum increase the inhibitory capacity on advanced glycation end products?

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