The Inhibitory Effect of (−)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity

Sheng, Jie; Shi, Weilin; Guo, Hui; Long, Wenlin; Wang, Yuxin; Qi, Jiangfa; Liu, Jinbiao; Xu, Yao

doi:10.3390/molecules24162899

Cited by 66 publications

(35 citation statements)

References 47 publications

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“…Theaflavin 1 was found to prevent lung tumorigenesis via induction of apoptosis, down-regulation of fatty acid synthase and COX-2 in cellular and animal models. Theaflavin 2 induced cell death by regulating BAX and p53 protein in the HeLa and WI38VA cervical cancer cell line [45,52,53]. On figure below (Figure 4), we present a comparison of polyphenol content in green and black tea, broken down into theaflavins and catechins.…”

Section: Differences Between Black Tea and Green Teamentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

462

250

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Green tea (Camellia sinesis) is widely known for its anticancer and anti-inflammatory properties. Among the biologically active compounds contained in Camellia sinesis, the main antioxidant agents are catechins. Recent scientific research indicates that the number of hydroxyl groups and the presence of characteristic structural groups have a major impact on the antioxidant activity of catechins. The best source of these compounds is unfermented green tea. Depending on the type and origin of green tea leaves, their antioxidant properties may be uneven. Catechins exhibit the strong property of neutralizing reactive oxygen and nitrogen species. The group of green tea catechin derivatives includes: epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. The last of these presents the most potent anti-inflammatory and anticancer potential. Notably, green tea catechins are widely described to be efficient in the prevention of lung cancer, breast cancer, esophageal cancer, stomach cancer, liver cancer and prostate cancer. The current review aims to summarize the potential anticancer effects and molecular signaling pathways of major green tea catechins. It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy. Nonetheless, their beneficial effects may support the standard anticancer approach.

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Section: Differences Between Black Tea and Green Teamentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

462

250

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“…Overexpression of SCUBE2 reversed epithelial mesenchymal transition (EMT) and associated cellular signaling in breast cancer. A recent study by Sheng et al reported that EGCG significantly inhibited DNMT activity and demethylated SCUBE2 promoter methylation [62]. This resulted in higher expression levels of SCUBE2 and reduced breast cancer progression.…”

Section: Epigallocatechin Regulates Tumor Suppressor Genes By Promotementioning

confidence: 97%

“…Current studies suggest that EGCG regulates DNA methylation and chromatin remodeling and alters the expression levels of different genes that regulate breast cancer proliferation and metastasis [58][59][60]. Following in vitro and in vivo studies, it was postulated that EGCG inhibits breast cancer proliferation and migration by regulating different tumor suppressor genes via its action of inhibiting DNA methyltransferases (DNMT) and histone deacetylases (HDAC) enzymes [61][62][63][64][65][66].…”

Section: Epigallocatechin Regulates Tumor Suppressor Genes By Promotementioning

confidence: 99%

“…EGCG is a well-studied flavonoid in breast cancer as an epigenetic modifier. Different studies postulated that EGCG acts as an inhibitor for DNMT and HDAC, resulting in the expression of different tumor suppressor genes [58][59][60][61][62][63][64][65][66]. Furthermore, different studies used EGCG together with another epigenetic modifier or a natural product and showed the combined action on regulating the epigenetic enzymes [64][65][66].…”

Section: Conclusion and Further Perspectivesmentioning

confidence: 99%

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Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

et al. 2020

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Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are present in plants, as secondary metabolites has been a major topic of research for many years. Our review analysis demonstrates that flavonoids exhibit anti-cancer activity against breast cancer occurring in different ethnic populations. Breast cancer subtype and menopausal status are the key factors in inducing the flavonoid’s anti-cancer action in breast cancer. The dose is another key factor, with research showing that approximately 10 mg/day of isoflavones is required to inhibit breast cancer occurrence. In addition, flavonoids also influence the epigenetic machinery in breast cancer, with research demonstrating that epigallocatechin, genistein, and resveratrol all inhibited DNA methyltransferase and altered chromatin modification in breast cancer. These flavonoids can induce the expression of different tumor suppressor genes that may contribute to decreasing breast cancer progression and metastasis. Additional studies are required to confirm the contribution of epigenetic modifications by flavonoids to breast cancer prevention.

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“…The natural polyphenol epigallocatechin-3-gallate (EGCG), found in green tea, was shown to inhibit DNMT activity by interacting with the enzyme catalytic pocket, reactivating the expression of several TSGs by reversing the hypermethylation status [ 116 , 117 ]. EGCG also decreased cell viability, migration and invasion of breast cancer cells, and SCUBE2 methylation by decreasing DNMT expression and activity [ 118 ]. Genistein is an isoflavone present in soybeans which displays anti-cancer activity [ 24 ].…”

Section: Dnmt Inhibitorsmentioning

confidence: 99%

DNA Methylation as a Therapeutic Target for Bladder Cancer

Nunes

Henrique

Jerónimo

et al. 2020

Cells

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Bladder cancer (BC) is the tenth most frequent cancer worldwide and is associated with high mortality when diagnosed in its most aggressive form, which is not reverted by the current treatment options. Thus, the development of new therapeutic strategies, either alternative or complementary to the current ones, is of major importance. The disruption of normal epigenetic mechanisms, namely, DNA methylation, is a known early event in cancer development. Consequently, DNA methyltransferase (DNMT) inhibitors constitute a promising therapeutic target for the treatment of BC. Although these inhibitors, mainly nucleoside analogues such as 5-azacytidine (5-aza) and decitabine (DAC), cause re-expression of tumor suppressor genes, inhibition of tumor cell growth, and increased apoptosis in BC experimental models and clinical trials, they also show important drawbacks that prevent their use as a valuable option for the treatment of BC. However, their combination with chemotherapy and/or immune-checkpoint inhibitors could aid in their implementation in the clinical practice. Here, we provide a comprehensive review of the studies exploring the effects of DNA methylation inhibition using DNMTs inhibitors in BC, from in vitro and in vivo studies to clinical trials.

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The Inhibitory Effect of (−)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity

Cited by 66 publications

References 47 publications

Beneficial Properties of Green Tea Catechins

Beneficial Properties of Green Tea Catechins

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

DNA Methylation as a Therapeutic Target for Bladder Cancer

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