The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer

Loo, Wings T.Y.; Cheung, Mary; Chow, Louis W.C.

doi:10.1016/j.lfs.2004.06.021

Cited by 45 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is cheaper than saffron and therefore a water extract of this flower is used instead of saffron. CT has wide pharmacological and biological activities including cardioprotective [6], neuroprotective [7] and antitumor activity [8]. Previous studies demonstrate that CT is toxic and causes renal and brain tissue damage [9,10].…”

Section: Introductionmentioning

confidence: 99%

Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

Mirhoseini

Mohamadpour

Khorsandi

2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Objective To evaluate the effects of aqueous extract of Carthamus tinctorius L., also named safflower, on mouse spermatogenesis. Methods Sixteen adult male NMRI mice were used. Experimental group received Carthamus tinctorius L. extract at the dose of 200 mg/kg for 35 consecutive days and control group received only distilled water. Testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the Carthamus tinctorius L. extract effects on testis.Results Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly decreased in Carthamus tinctorius L. treated mice (p<0.001). Carthamus tinctorius L. extract induced formation of multinucleated giant cells in the germinal epithelium. Carthamus tinctorius L. extract also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Carthamus tinctorius L. extract has toxic effects on mouse testicular tissue, and recommended to use it with caution if there is a reproductive problem.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

Mirhoseini

Mohamadpour

Khorsandi

2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…In addition, they may exert their estrogenic influence through either or both of receptor-dependent and receptor-independent mechanisms [33][34][35] . Other studies demonstrate inhibition of breast cancer cell models, particularly by ginseng and its extracts [36][37][38][39][40][41] . Piersen reviewed the conflicting data in detail 42 .…”

Section: Hormone Effectsmentioning

confidence: 99%

“…Water-extracted compounds of Panax quinquefolius L. inhibit MCF-7 cell proliferation by inhibiting mitogen-activated protein kinase 40 . A combination herbal formula of ginseng and Carthami tinctorii inhibits a breast cancer cell line through apoptosis 38 .…”

Section: Hormone Effectsmentioning

confidence: 99%

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Sagar

Wong

2008

Current Oncology

View full text Add to dashboard Cite

Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions selected as part of a care plan based on TCM diagnostic theory. Combining TCM with the modern practice of oncology seems, in conjunction with biomedical interventions (surgery, radiotherapy, chemotherapy, and pharmaceuticals), to have potential advantages through the synergy of biomodulation. Biomodulation approaches are broadly categorized as modification of tumour response and reduction of adverse effects; modulation of immunity; prevention of cancer progression; and enhancement of symptom control. Although the database of preclinical studies is rapidly expanding, good-quality clinical trials are notably scarce.Laboratory studies suggest that some herbs increase the effectiveness of conventional chemotherapy without increasing toxicity. A healthy immune system is necessary for control of malignant disease, and the immune suppression associated with cancer contributes to its progression. Many Chinese herbs contain glycoproteins and polysaccharides (among them, constituents of Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Astragalus membranaceus, Panax ginseng, and various other medicinal mushrooms) that can modulate metastatic potential and the innate immune system. Phytochemicals such as specific polysaccharides have been shown to boost the innate immune system, especially through interaction with Tolllike receptors in mucosa-associated lymphoid tissue. This intervention can potentially improve the effectiveness of new anticancer vaccines. An increase in virusassociated cancers presents a major public health problem that requires novel therapeutic strategies. A number of herbal therapies have both antiviral activity and the ability to promote immunity, possibly inhibiting the initiation and promotion of virus-associated cancers.The mechanisms learned from basic science should be applied to clinical trials both of specific interventions and of whole-system care plans that safely combine the TCM approach with the conventional biomedical model. In Western medicine, the combination of TCM herbs with drug therapies is controversial, given lack of knowledge concerning whether a drug is favourably enhanced or whether adverse effects occur. Using initial data from the preclinical studies, future clinical research needs to evaluate the combinations, some of which are showing favourable synergy.

show abstract

“…Plants are 30-150 cm length with globular flower heads and brilliant yellow, orange or red flowers [3]. Carthamus tinctorius has biological and pharmacological activities including cardioprotective [4], swelling associated with trauma, antidepressant [5], sedative, antiinflammatory and anti-tumor activities [6][7], neuroprotective [8], inhibition of platelet aggregation, increase of peripheral blood flow, increase in the beating amplitude of cultured myocardial cell sheet and inhibition of tumor promotion in mice [9]. In Korea, Safflower was used for the promotion of bone formation and in the treatment of rheumatism and osteoporosis [10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Carthamus Tinctorius Safflower Aqueous Extract Against Nickel Chloride Induces Hematotoxicity and Immunotoxicity in Adult Male Rabbits

Laylani¹

2017

IHJPAS

View full text Add to dashboard Cite

This study was designed to show, the role of Carthamus tinctorius safflower aqueous extract against toxicity of nickel chloride (NiCl 2 ). Twenty male, rabbits were used and divided into four groups (with 5 rabbits in each group); group (control group) received normal diet, group II received orally 100mg/kg NiCl 2 for six weeks, group III received 100mg/kg NiCl 2 and 100mg/kg extract six weeks, group IV received 100mg/kg NiCl 2 and 200mg/ kg extract six weeks. Hematological parameters showed (RBC (Red blood cells), Hb (Hemoglobin), PCV (Packed cells volume) decreased and WBC (White blood cells) increased) significant changes (P < 0.05) compared with control group. Immunological parameters (IgG, IgA and IgM increased) and oxidative stress factors (MDA increased and GSH decreased) show significant changes (P < 0.05) compared with control group. While, safflower aqueous adverse the negative effects of NiCl 2 and causing ameliorative effects on all hematological parameters, hematological immunological parameters and oxidative stress factors showed no significant changes (P < 0.05) compared with control group. It was concluded that flower extract of Carthamus tinctorius has been antioxidant role against nickel chloride toxicity in rabbits.

show abstract

The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer

Cited by 45 publications

References 19 publications

Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Effect of Carthamus Tinctorius Safflower Aqueous Extract Against Nickel Chloride Induces Hematotoxicity and Immunotoxicity in Adult Male Rabbits

Contact Info

Product

Resources

About