The inhibitor of apoptosis protein livin is upregulated in psoriasis vulgaris

Wang, H.; Ran, Li-Wei; Hui, Ke; Pei, Xiaorui; Wang, X.; Zheng, Yan

doi:10.1111/jdv.14768

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…In 2018, our research group found that the expression of Livin in the KCs of skin lesions in psoriasis patients was higher than the healthy skin samples in JEADV, while the function of Livin in KCs and psoriasis was still unclear. 8 Livin upregulation promoted KC proliferation and inhibited their apoptosis. 9 However, the regulatory mechanisms of KC activation and the release of inflammatory mediators in psoriasis have not yet been reported.…”

Section: Introductionmentioning

confidence: 94%

“…In addition, Livin expression was significantly upregulated in the KCs of patients with psoriasis. In 2018, our research group found that the expression of Livin in the KCs of skin lesions in psoriasis patients was higher than the healthy skin samples in JEADV, while the function of Livin in KCs and psoriasis was still unclear 8 . Livin upregulation promoted KC proliferation and inhibited their apoptosis 9 .…”

Section: Introductionmentioning

confidence: 99%

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Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis

Che,

Li,

Hang

et al. 2024

Skin Research and Technology

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BackgroundPsoriasis is a prevalent, long‐term skin condition characterized by inflammation. Keratinocytes (KCs) are important effector cells that release inflammatory factors and chemokines to promote the inflammatory cascade in psoriasis. However, the mechanisms underlying the activation of KCs in psoriasis remain unclear. Livin suppresses apoptotic proteins and directly affects the growth and spread of cancer cells. Livin expression reportedly increases significantly in lesions of patients with psoriasis; however, its specific role in KC activation remains unknown. This study aimed to examine the impact of Livin on KC activation and the subsequent release of inflammatory mediators.MethodsImmunofluorescence staining, reverse transcription‐quantitative polymerase chain reaction, enzyme‐linked immunosorbent assay (ELISA), and western blotting were used to assess Livin expression in patients with psoriasis, an imiquimod (IMQ)‐induced psoriasis‐like mouse model, and M5‐treated HaCaT cells. To investigate the role of Livin in KCs, we performed RNA sequencing and proteomic analysis of Livin‐knockdown (knockdown‐HaCaT) and negative control (NC‐HaCaT) cells. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for enrichment analyses. Moreover, the effect of Livin expression on the release of inflammatory mediators in KCs was verified using ELISA.ResultsLivin expression was higher in KCs of patients with psoriasis than in those healthy controls. Livin expression in HaCaT cells treated with M5 increased significantly over time. Livin expression was higher in the skin lesions of the IMQ mouse model than in the control group. Proteomic analysis and RNA sequencing used to investigate the function of Livin in HaCaT cells revealed its potential role in mediating KC activation and inflammatory mediator release, which affected the pathology of psoriasis.ConclusionsLivin expression played an effect on KCs activation, which induced release of inflammatory mediators and up‐regulation of keratin. This study provides a new effector molecule for the mechanism of inflammatory response in psoriasis.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis

Che,

Li,

Hang

et al. 2024

Skin Research and Technology

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“…It has an important relationship with the formation of many tumor cells, which may be caused by its antiapoptotic effect. Livin expression is shown to be significantly upregulated in KC of psoriasis lesions 11 . However, there are few studies on the function of Livin in KCs and its effect on the pathogenesis of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…Livin expression is shown to be significantly upregulated in KC of psoriasis lesions. 11 However, there are few studies on the function of Livin in KCs and its effect on the pathogenesis of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression

Che

Hang

et al. 2023

Int J Dermatology

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Background Activation of keratinocytes (KCs) is the main pathological feature of psoriasis.KCs recruit neutrophils by releasing various antimicrobial peptides and chemokines, which is also related to the expression of KC adhesion molecules. However, the regulatory mechanism governing their expression is still unclear. Livin, an inhibitor of the apoptosis protein family member involved in proliferation and metastasis of tumor cells, is significantly increased in psoriatic lesions.Objectives The aim of this study was to investigate the role of Livin in regulating adhesion molecule expression in KCs and release of chemokines that promote the activation and adhesion of neutrophils. MethodsThe expression of Livin in psoriasis patients, imiquimod mouse model, and the combination of IL-17 alpha, IL-22, IL-1 alpha, OSM, and TNF-a (Mix M5)-treated HaCaT cells were detected by immunofluorescence staining, RT-qPCR, and ELISA. Livinoverexpression and knockdown in HaCaT cells transfected with HIV-1-based lentiviral vectors were used to study the function of Livin using RNA-seq. Moreover, differences in the expression of HaCaT cell adhesion molecules after regulation of Livin expression and activation of neutrophils in the co-culture model were verified. Results Livin was upregulated in the KCs of psoriasis patients, imiquimod mouse model and Mix M5-treated HaCaT cells compared with the control groups. Livin in HaCaT cells might regulate the expression of adhesion molecules in KCs. Conclusion Thus, Livin may be a key effector molecule that regulates the expression of adhesion molecules in KCs and promotes the activation and adhesion of neutrophils.

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Impact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris

Ali

Khallaf

Kamel

et al. 2022

Journal of Drug Delivery Science and Technology

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The inhibitor of apoptosis protein livin is upregulated in psoriasis vulgaris

Cited by 5 publications

References 6 publications

Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis

Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis

Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression

Impact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris

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