The Inhibition of Glutathione Reductase by Quinones

Bironaitė, Daiva; Čėnas, Narimantas; Kulys, Juozas; Меденцев, А. Г.; Akimenko, Vasiliy K.

doi:10.1515/znc-1991-9-1042

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Inhibitors Of T Cruzi Trypanothione Reductase1

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Cited by 11 publications

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“…Because nitrofuran compounds inhibit structurally related antioxidant enzymes other than TR, including the host GR [139][140][141], it is desirable to design nitrofuran inhibitors which selectively interact with the parasite flavoenzyme. Several research groups were devoted to that task and as a result, some promising nitrocompounds were reported.…”

Section: Inhibitors Of T Cruzi Trypanothione Reductasementioning

confidence: 99%

The Chemotherapy of Chagas Disease: An Overview

Paulino

Iribarne²,

Dubin³

et al. 2005

MRMC

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The review presents: a) a brief description of the disease; b) a summary of the most important metabolic targets so far identified in Trypanosome cruzi (T. cruzi) along with corresponding inhibitor compounds; c) the current state of knowledge on the trypanothione reductase system of trypanosomatids with reference to oxidative stress defenses; d) detailed discussions on T. cruzi trypanothione reductase inhibitors such as nitrofuranes, naphthoquinones and phenothiazines. As yet, the chemotherapy of Chagas' disease remains an unsolved problem. Further search for new drugs must continue by means of nucleating existing chemotherapy efforts.

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Section: Inhibitors Of T Cruzi Trypanothione Reductasementioning

confidence: 99%