The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

Mk, Church; Collier, H. O. J.; James, Genevieve

doi:10.1111/j.1476-5381.1972.tb06848.x

Cited by 56 publications

(52 citation statements)

References 45 publications

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“…3). Antagonists of serotonin and SRS-A, such as methysergide or FPL 55712 partially inhibit bronchoconstriction induced in rats (2,5,16). In the present experi ment, a partial inhibition of the bronchoconstriction in rats occurred following treatment with cyproheptadine.…”

supporting

confidence: 50%

Anti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.

Goto¹,

Terasawa²,

Kadobe³

et al. 1980

Jpn.J.Pharmacol

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Abstract-The active anaphylactic bronchoconstriction of rats mediated by IgE-like antibody against DNP-Ascaris was inhibited by intravenous and intratracheal treat ment with Y-12,141 in a dose-dependent manner. In both routes, the inhibitory effect of Y-12,141 on this response was more potent than that of disodium cromoglycate (DSCG). The oral administration of Y-12,141 also produced a similar inhibition of the response. The passive anaphylactic bronchoconstriction of guinea pigs mediated by IgG-like antibody against egg albumin was also prevented dose-dependently by treatment with Y-12,141 given intravenously, but not with DSCG. The present results suggest that Y-12,141 may be effective for the treatment of allergic bronchial asthma.In a previous paper (1), we demonstrated that 9-chloro-5-oxo-7-(1H-tetrazol-5-yl) The active anaphylactic bronchoconstriction in rats sensitized with several antigens such as egg albumin provides a model which is similar to human bronchial asthma im munologically and in the response to DSCG (2-6). In addition, the anaphylactic broncho constriction in guinea pigs is usually chosen for the experimental simulation of human allergic bronchial asthma (7). However, the anaphylactic bronchoconstriction in guinea pigs differs from human allergic asthma both in the immunoglobulins involved (8, 9) and in the response to DSCG (10). The present studies were designed to elucidate the effectiveness of Y-12,141 for prophylaxis in the bronchial anaphylaxis in both rats and guinea pigs. MATERIALS AND METHODS Animals:Rats, guinea pigs and rabbits were used. The animals were housed under ordinary conditions and allowed free access to food and water.

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supporting

confidence: 50%

Anti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.

Goto¹,

Terasawa²,

Kadobe³

et al. 1980

Jpn.J.Pharmacol

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“…For 3CA, intramolecular H-bonds (H· · ·O interactions, yielding a 6-membered ring) are clearly favoured over the intermolecular ones, the opposite being true for 2CA which is suggested to occur as a favoured top-to-top dimer in the condensed phase. This is in accordance with the extremely high pK a value previously reported for the 3-carboxylic chromone (8.85 [35] and presently calculated as 8.70), in contrast to 2CA's pK a (2.55 [36], currently calculated as 3.02).…”

Section: Discussionsupporting

confidence: 51%

“…Actually, this is the only species expected to occur at room temperature since the next calculated conformers correspond to very high relative energies ( E = 28.5, 34.1 and 65.0 kJ mol −1 , Table 1). Furthermore, this preferred intramolecular (O 10 )H· · ·O 12 ( C) close contact justifies the abnormally high pK a value reported for 3CA -8.85 [35] as compared to 2.55 [36] for the 2-carboxylic analogue, for which no such interaction is possible. These pK a values were presently confirmed by DFT calculations: 8.59 and 2.04 were obtained for the most stable conformers of 3CA and 2CA, respectively.…”

Section: Conformational Analysismentioning

confidence: 92%

Conformational behaviour of antioxidant chromones. A vibrational spectroscopy study

Machado

Valero

Domingos

et al. 2012

Vibrational Spectroscopy

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a b s t r a c tChromone and two carboxylic derivatives -chromone-2-carboxylic acid (2CA) and chromone-3-carboxylic acid (3CA) -were investigated as to their conformational preferences by vibrational spectroscopy -Raman, FTIR and INS -combined to density functional theory and plane-wave calculations. INS experiments allowed to clearly detect intramolecular hydrogen-type close contacts in these systems. A natural bond orbital (NBO) analysis was performed, including calculation of the second-order perturbation energies (E (2) ) and orbital occupancies, to provide theoretical evidence of the stabilisation due to the * i → * j donor-acceptor interaction. A complete assignment of the vibrational spectra was achieved for all compounds, allowing us to determine their most stable conformers and establish their H-bonding profile. 3CA was shown to display a particularly strong intramolecular H-bond, which can explain its singular conformational behaviour and abnormally high pK a value.

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“…This is in contrast to the 'bell-shaped' dose-inhibitory response curve produced against anaphylactic bronchoconstriction in actively sensitized rats (Church, Collier & James, 1972).…”

Section: Discussionmentioning

confidence: 54%

Mediators of Passive Lung Anaphylaxis in the Rat

Farmer¹,

Richards²,

Sheard³

et al. 1975

British J Pharmacology

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1 Passive lung anaphylaxis (PLA) was investigated in rats sensitized by the intravenous injection of high titre reaginic antiserum prepared in rats. 2 The effect of various pharmacological antagonists on anaphylactic bronchoconstriction in vivo were examined. An antihistamine (mepyramine), a kallikrein inactivator (aprotinin) or a prostaglandin synthesis inhibitor (aspirin) did not inhibit PLA, whereas an anti-5-hydroxytryptamine agent (methysergide) and an anti-slow reacting substance-A agent (FPL, 55712) significantly reduced the response. 3 Isolated perfused lungs taken from sensitized rats released, on challenge with the sensitizing antigen, histamine, 5-hydroxytryptamine, slow reacting substance of anaphylaxis (SRS-A) and prostaglandins, but no rabbit aorta contracting substance (RCS). 4 Disodium cromoglycate inhibited both anaphylactic bronchoconstriction in vivo and the anaphylactic release of mediators in vitro. Inhibition in vivo was dose-related. 5 Mediators from the intestine, the primary shock organ of anaphylaxis in the rat, did not contribute to the lung response. 6 Vagal reflex pathways were found not to be important in PLA in vivo. 7 The relationship between the mediators released following antigen challenge of passively sensitized rat lung in vitro and passive lung anaphylaxis in vivo is discussed.

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The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

Cited by 56 publications

References 45 publications

Anti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.

Anti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.

Conformational behaviour of antioxidant chromones. A vibrational spectroscopy study

Mediators of Passive Lung Anaphylaxis in the Rat

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