The inhalation test as a diagnostic procedure with special emphasis on the house dust allergen

Schiller, Irving W.; Lowell, Francis C.

doi:10.1016/0021-8707(52)90022-1

Cited by 30 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The FEV 1 was named and its technology standardized in 1957 (32). Initial use of expiratory flow rates to measure the EAR included the somewhat subjective end points of a clearcut reduction in expiratory flows (33) or the French equivalent the dose liminaire required to produce a tangible spirometric change (34). The FEV 1 , now the standard end point for measurement of most bronchoprovocation studies with allergen or others, became established in the late 1950s (35) and thereafter as the end point, generally expressed as a percentage change, used to monitor allergen provocation.…”

Section: Early Asthmatic Responsementioning

confidence: 99%

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

Gauvreau

et al. 2007

Allergy

View full text Add to dashboard Cite

Allergen bronchoprovocation tests have been used for more than two decades in the investigation of respiratory allergic diseases such as asthma and rhinitis. These bronchial challenges are now well standardized and can offer key information on the therapeutic potential of new agents and on their anti‐inflammatory effects on the airways. Both standard and low‐dose allergen provocations are safe when performed by experienced investigators and do not lead to persistent worsening of asthma or change in airway function. The evaluation of new therapeutic agents by these methods can also provide important information on the mechanisms of development and persistence of airway diseases.

show abstract

Section: Early Asthmatic Responsementioning

confidence: 99%

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

Gauvreau

et al. 2007

Allergy

View full text Add to dashboard Cite

show abstract

“…Since Curry [1946,1947], Curry and Lowell [1948], H erxheimer [1951 a-c, 1952], H erxheimer and Prior [1952] and Tiffeneau [1955, 1959 a, b], Tiffeneau and Beauvallet [1945], Tiffeneau and Brutel [1955] described the bronchoconstrictor effect of inhaled histamine, acetylcholine, and allergens on the respiratory tract in patients with chronic nonspecific lung diseases (CNSLD), numerous publications have been devoted to this subject [Beumer, 1966;Bouhuys, 1967;Bouhuys et al, 1960;D ukstra, 1963;Citron, 1967;Colldahl, 1967;D ebelic, 1968;D ebelic and Vir chow, 1970;Fréour et al, 1970;G roetenbriel et a l, 1968;G ronemeyer and Fuchs, 1959; K lein and Salvaggio, 1966; Lecomte and Petit, 1960;Maier et al, 1970;Makino, 1966;Marcelli, 1963;Marcelli et al, 1965;N ilsson and Kaude, 1960;Rebohle and Jager, 1968;Segal et al, 1949;Schiller and Lowell, 1952;Stennis, 1970;De Vries et al, 1964, 1968.…”

Section: Introductionmentioning

confidence: 99%

Response to Inhaled Histamine and to Inhaled Allergens in Atopic Patients

Kreukniet¹,

Pijper²

1973

Respiration

View full text Add to dashboard Cite

In atopic patients with chronic non specific lung diseases, the sensitivity of the bronchial tree to histamine and to allergens was studied by means of inhalation provocation tests. An unmistests takable correlation was demonstrated between the results of histamine inhalation provocation tests tests (HIPT) and allergen inhalation provocation tests (AIPT).When the HIPT revealed a higher sensitivity to histamine, the AIPT disclosed a higher sensitivity to allergens. This was manifested by the larger number of allergens to which the patients reacted at AIPT, as well as by the severity of the reaction after AIPT, as measured spirographically. Moreover, higher sensitivity to histamine was associated with more late positive reactions after AIPT

show abstract

“…He wrote: However, in clinical reality with humans an universal shock mostly does not occur, rather only one or several symptoms of a shock are clearly apparent, which we want to call 'shock fragments'. Richard Otto (1872-1952 fig. 17 ) worked at the Imperial Health Centre in Berlin and documented further important details of anaphylaxis: the incubation time is between 8-10 days, the reaction is specific and stops approximately 2-3 months later, the sensitization can be transferred passively by mothers to their newborns and a large number of antigens (animal, herbal, bacterial) are able to induce anaphylactic reactions, including non-toxic antigens [18] .…”

Section: Anaphylaxis In the Clinical Routinementioning

confidence: 99%

“…A reduction of 10% in vital capacity was considered as evidence of sensitivity. The incidence of skin reactions was much higher than of pulmonary reactions, and there were no pulmonary reactions with allergens which did not result in skin reactions [51] .…”

Section: Inhalation Testsmentioning

confidence: 99%

Milestones in the 20th Century

Bergmann

2014

History of Allergy

View full text Add to dashboard Cite

From its very beginning, the 20th century represented the period of the main breakthrough for allergology as a clinical and scientific entity. The first years of this period were extraordinarily exciting because of the discovery of the anaphylactic reaction in 1902 and its clinical diagnosis as 'local anaphylaxis', 'serum sickness' (1903) or even as 'anaphylactic shock' (1907). The term 'allergy' was coined in 1906 and led to the recognition of allergic diseases as a pathogenetic entity. The first patient organization of hay fever sufferers was founded in Germany in 1900, the same year in which the very first report on immunotherapy was published in New York. In 1911 the era of actual immunotherapy started in London, becoming scientific with the first double-blind study in 1956, and still today being regarded as the backbone of allergology. In 1919 it was shown that allergy could be transferred by blood, in 1921 by serum (Prausnitz-Küstner test) and in 1966 the mystic 'reagins' were recognized as immunoglobulin (Ig) E. The development of the radioallergosorbent test for quantifying specific IgE antibody was a diagnostic landmark for allergists all over the world. The history of allergy diagnosis started with the introduction of a 'functional skin test', named the patch test in 1894. The scratch test was described in 1912 and the patch test in 1931. From 1908 the skin was tested by intracutaneous injections, and from 1930 by a 'puncture test' (a precursor of the prick test) which has been in worldwide use in modified variations since 1959. The rub test ('friction test') was added in 1961. Systematically applied provocation tests started with conjunctival provocation (1907), followed by nasal and bronchial provocation with allergens (1914 and 1925).

show abstract

The inhalation test as a diagnostic procedure with special emphasis on the house dust allergen

Cited by 30 publications

References 7 publications

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

Response to Inhaled Histamine and to Inhaled Allergens in Atopic Patients

Milestones in the 20th Century

Contact Info

Product

Resources

About