The Influence of Valproic Acid and Carbamazepine Treatment on Serum Biotin and Zinc Levels and on Biotinidase Activity

Castro-Gago, Manuel; Pérez-Gay, Laura; Gómez-Lado, Carmen; Otero-Martínez, Santiago; Rodrı́guez-Segade, Santiago

doi:10.1177/0883073811409227

Cited by 19 publications

(11 citation statements)

References 19 publications

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“…Hair regrowth in this patient occurred after 2 months of biotin supplementation. Only 1 study conducted by Castro-Gago et al [14] showed decreased levels of both biotin and biotinidase secondary to medication usage (valproic acid) that improved after 3 months of supplementation with biotin. Finally, 3 cases of brittle nail syndrome treated with biotin were found in the literature and each case showed improvement of nail strength as well as growth on either 2,500 or 3,000 μg of biotin/day.…”

Section: Methodsmentioning

confidence: 99%

A Review of the Use of Biotin for Hair Loss

Patel

Swink

Castelo‐Soccio

2017

Skin Appendage Disord

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Background: Biotin has gained commercial popularity for its claimed benefits on healthy hair and nail growth. Despite its reputation, there is limited research to support the utility of biotin in healthy individuals. Objective: To systematically review the literature on biotin efficacy in hair and nail growth. Methods: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin and hair); (biotin and supplementation and hair); (biotin supplementation); (biotin and alopecia); (biotin and nails); (biotin and dermatology), and (biotin recommendations). Results: We found 18 reported cases of biotin use for hair and nail changes. In all cases, patients receiving biotin supplementation had an underlying pathology for poor hair or nail growth. All cases showed evidence of clinical improvement after receiving biotin. Conclusions: Though its use as a hair and nail growth supplement is prevalent, research demonstrating the efficacy of biotin is limited. In cases of acquired and inherited causes of biotin deficiency as well as pathologies, such as brittle nail syndrome or uncombable hair, biotin supplementation may be of benefit. However, we propose these cases are uncommon and that there is lack of sufficient evidence for supplementation in healthy individuals.

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Section: Methodsmentioning

confidence: 99%

A Review of the Use of Biotin for Hair Loss

Patel

Swink

Castelo‐Soccio

2017

Skin Appendage Disord

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“…Prophylactic use of antiepileptic drugs has been considered to reduce the recurrence of complex FS [4], but it can also induce several side effects, such as drowsiness, hyperactivity, or learning difficulties by phenobarbital [5] and weight gain, nausea, hair loss, or liver injury by valproic acid [6], [17]–[19]. The development of less toxic prophylactic treatments for complex FS is thus necessary to help children with FS, and we therefore analyzed the effect of a herbal medicine that has been widely used in Asian countries.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsive Effect of Paeoniflorin on Experimental Febrile Seizures in Immature Rats: Possible Application for Febrile Seizures in Children

et al. 2012

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Febrile seizures (FS) is the most common convulsive disorder in children, but there have been no clinical and experimental studies of the possible treatment of FS with herbal medicines, which are widely used in Asian countries. Paeoniflorin (PF) is a major bioactive component of Radix Paeoniae alba, and PF-containing herbal medicines have been used for neuromuscular, neuropsychiatric, and neurodegenerative disorders. In this study, we analyzed the anticonvulsive effect of PF and Keishikashakuyaku-to (KS; a PF-containing herbal medicine) for hyperthermia-induced seizures in immature rats as a model of human FS. When immature (P5) male rats were administered PF or KS for 10 days, hyperthermia-induced seizures were significantly suppressed compared to control rats. In cultured hippocampal neurons, PF suppressed glutamate-induced elevation of intracellular Ca2+ ([Ca2+]i), glutamate receptor-mediated membrane depolarization, and glutamate-induced neuronal death. In addition, PF partially suppressed the elevation in [Ca2+]i induced by activation of the metabotropic glutamate receptor 5 (mGluR5), but not that mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) or N-methyl-D-aspartate (NMDA) receptors. However, PF did not affect production or release of γ-aminobutyric acid (GABA) in hippocampal neurons. These results suggest that PF or PF-containing herbal medicines exert anticonvulsive effects at least in part by preventing mGluR5-dependent [Ca2+]i elevations. Thus, it could be a possible candidate for the treatment of FS in children.

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“…Davison et al 2011 It may reduce the serum and hair zinc. Armutcu et al 2004Yilmaz et al 2009Castro-Gago et al 2011 High-fat diet and soy intake with drug should be avoided. Zhang et al 2014Marahatta et al 2014 Gabapentin, pregabalin, carbamazepine and VPA High protein intake may prevent levodopa to cross blood brain barrier.…”

Section: Anticonvulsant/antiepileptic Drugsmentioning

confidence: 99%

Role of food-drug interactions in neurological and psychological diseases

Karadağ¹,

Çelik²,

Kadayifçi³

et al. 2018

Acta Neurobiologiae Experimentalis

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Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food-drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food-drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews, reports, and original articles on general or specific drug interactions with food, in patients with a variety of neurological and psychological diseases. Based on our review, we found that food-drug interactions may alter the expected impact of drug, or cause the development of a drug toxicity. Nutritional status of the patients may also be affected, particularly a change in body weight caused by a change appetite. Metabolism, absorption, and excretion of foods may also be altered, and nutritional insufficiencies may occur. Recent studies show that diet can have a strong influence on gut microbiota and thus, alter drug pharmacokinetics.Therefore, microbiota alterations should also be considered while assessing food-drug interactions. Knowledge of food-drug interactions is critical for improving health of patients with neurological and psychological diseases, and also for improving effectiveness of treatments.

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The Influence of Valproic Acid and Carbamazepine Treatment on Serum Biotin and Zinc Levels and on Biotinidase Activity

Cited by 19 publications

References 19 publications

A Review of the Use of Biotin for Hair Loss

A Review of the Use of Biotin for Hair Loss

Anticonvulsive Effect of Paeoniflorin on Experimental Febrile Seizures in Immature Rats: Possible Application for Febrile Seizures in Children

Role of food-drug interactions in neurological and psychological diseases

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