The influence of vaccine preparations on the induction of antigen specific responsiveness in rainbow troutOncorhynchus mykiss

Marsden, Matthew J.; Secombes, Christopher J.

doi:10.1006/fsim.1997.0098

Cited by 21 publications

(11 citation statements)

References 23 publications

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“…In the present study the kinetics of antibody formation following vaccination is in agreement with earlier vaccine reports of trout and salmon [15,31] since both the vaccine groups had increased level of antibodies at 6 weeks post-vaccination. However, the plasma antibody titer and the antibody-enhanced whole blood respiratory burst (RB) activity that originated from the ingestion response of monocytes and granulocytes were partially inconsistence.…”

Section: Discussionsupporting

confidence: 93%

Multiple whole bacterial antigens in polyvalent vaccine may result in inhibition of specific responses in rainbow trout (Oncorhynchus mykiss)

Nikoskelainen

Verho

Järvinen

et al. 2007

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 93%

Multiple whole bacterial antigens in polyvalent vaccine may result in inhibition of specific responses in rainbow trout (Oncorhynchus mykiss)

Nikoskelainen

Verho

Järvinen

et al. 2007

Fish & Shellfish Immunology

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“…This might be due to polyclonal activation of leukocyte already sensitized with the antigen. Similar antigen-specific proliferative responses have also been reported in catla [24] and other fish species [25,26]. Significantly higher proliferative response by FE þ A group compared to the control group demonstrated higher efficacy of the vaccine when it was mixed with adjuvant.…”

Section: Discussionsupporting

confidence: 74%

“…However, the importance of protective antibody for resistance to pathogen does not negate the role of cellular immune responses following vaccination. In fact, antibody production, resulting from the primary effector cell proliferation and their differentiation into both specific antibody secreting cells and memory cells, is often a complex process requiring cell cooperation and cytokine production able to promote these events [25].…”

Section: Discussionmentioning

confidence: 99%

Immune responses and protection in catla (Catla catla) vaccinated against epizootic ulcerative syndrome

Saikia

Kamilya

2012

Fish & Shellfish Immunology

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“…A protective vaccine should contain antigens that are expressed in vivo and involved in disease pathogenesis (Marsden & Secombes 1997). Previous studies have demonstrated that although vaccination can lead to measurable antibody titres, these are not correlated with protection (Ellis 1997).…”

Section: Discussionmentioning

confidence: 99%

Vaccination trials of sea bass, Dicentrarchus labrax (L.), against Photobacterium damsela subsp. piscicida, using novel vaccine mixtures

Bakopoulos¹,

Volpatti²,

Gusmani³

et al. 2003

Journal of Fish Diseases

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Bacterial cells of the marine fish pathogen Photobacterium damsela subsp. piscicida were grown in novel culture media. A mixture of whole cells and extracellular components was inactivated and used in bath, intraperitoneal (i.p.) and oral vaccination of sea bass, Dicentrarchus labrax, employing two sizes of fish. A commercial vaccine was used for comparative purposes. Control and immunized fish were either bath or intraperitoneally challenged 6 and 12 weeks post-vaccination. Small fish had significantly higher relative percentage survival with the novel vaccine mixture both at 6 and 12 weeks post-vaccination by bath, in comparison with the commercial vaccine. No protection was afforded at 6 or 12 weeks post-immunization by either vaccine after challenge via i.p. injection. Sea bass (1.5-2 g) intraperitoneally vaccinated with various adjuvanted vaccine mixtures were not protected against pasteurellosis. In contrast, larger sea bass (20 g) benefited from vaccination with the novel vaccine mixtures. Intraperitoneal challenge with the pathogen resulted in protection in both fish groups vaccinated with novel vaccine mixtures, whereas control fish suffered high mortalities (> 80%). Orally vaccinated fish were immersion challenged with the pathogen. At 6 and 12 weeks post-vaccination the control fish had a high mortality and the fish vaccinated with the novel vaccine mixture achieved good protection.

show abstract

The influence of vaccine preparations on the induction of antigen specific responsiveness in rainbow troutOncorhynchus mykiss

Cited by 21 publications

References 23 publications

Multiple whole bacterial antigens in polyvalent vaccine may result in inhibition of specific responses in rainbow trout (Oncorhynchus mykiss)

Multiple whole bacterial antigens in polyvalent vaccine may result in inhibition of specific responses in rainbow trout (Oncorhynchus mykiss)

Immune responses and protection in catla (Catla catla) vaccinated against epizootic ulcerative syndrome

Vaccination trials of sea bass, Dicentrarchus labrax (L.), against Photobacterium damsela subsp. piscicida, using novel vaccine mixtures

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