The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study

Daehnhardt, D.; Daehnhardt-Pfeiffer, S.; Schulte-Walter, Judith; Neubourg, Thomas; Hanisch, Eckhard; Schmetz, Christel; Breuer, Marion; Fölster‐Holst, Regina

doi:10.1159/000448690

Cited by 9 publications

(11 citation statements)

References 16 publications

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“…In the future, hopefully there will be clinical evidence that lipid pattern can be influenced by the supplementation of adapted mixtures of FFAs or by induction/normalization of FFAs synthesis, with the aim of strengthening the skin barrier function of the elderly or in subjects with diabetes mellitus [57].…”

Section: Discussionmentioning

confidence: 99%

Age- and Diabetes-Related Changes in the Free Fatty Acid Composition of the Human Stratum Corneum

Wohlrab¹,

Gabel

Wolfram

et al. 2018

Skin Pharmacol Physiol

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Of particular importance for Stratum corneum (SC) lipids are the free fatty acids (FFAs). Age-related changes of the SC structure lead to diminished capacity for barrier compensation. The aims of this cross-sectional study were to identify even-numbered especially odd-numbered FFAs within the intercorneocytic lamellar lipid structures of the SC and to explore age- and diabetes-related changes in FFAs. Gas chromatography – flame ionisation detection was used to qualitatively and quantitatively assess FFAs extracted from the SC. 110 subjects aged over 60 years (elderly/healthy), 110 subjects aged 18–40 (young/healthy) and 38 subjects with diabetes mellitus aged 18–40 (young/diabetic) were investigated. Overall, odd-numbered FFAs comprised about 21, 23 and 24% of total FFAs in subgroups elderly/healthy, young/healthy and young/diabetic. The most abundant short-chain FFAs were C16: 0 and C18: 0 and long-chain FFAs were C24: 0 and C26: 0. Only levels of C15: 0 and C17: 0 decreased with age. In contrast, levels of C18: 2 and C19 were significantly decreased and levels of C15, C17, C18: 1 and C23 were significantly increased in young diabetic subjects. In general, compared with younger healthy subjects, FFA composition was only partly significantly altered in older healthy subjects but was significantly altered in younger diabetic subjects.

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Section: Discussionmentioning

confidence: 99%

Age- and Diabetes-Related Changes in the Free Fatty Acid Composition of the Human Stratum Corneum

Wohlrab¹,

Gabel

Wolfram

et al. 2018

Skin Pharmacol Physiol

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“…In the treatment of xerosis of the feet, a ceramide‐ containing topical preparation that also contained urea 10 %, glycerol, fatty acids, allantoin and panthenol showed more rapid reorganization of the lipid lamellae in the stratum corneum as well as greater improvement in TEWL and skin hydration than the vehicle .…”

Section: Management Of Xerosis Cutismentioning

confidence: 99%

Diagnosis and treatment of xerosis cutis – a position paper

Augustin

Wilsmann‐Theis²,

Körber³

et al. 2019

J Deutsche Derma Gesell

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Summary Background and rationale Xerosis cutis (also referred to as xeroderma, dry skin, asteatosis) affects more than 10 million individuals in Germany. It is among the most common dermatological diagnoses and a cardinal symptom of many dermatological, internal and neurological diseases. Even though it has been established that basic skin care plays a significant role in the management of patients with xerosis cutis, there are as yet no evidence‐based algorithms for diagnosis and treatment. Objective The present position paper provides physicians across all specialties with a practical, symptom‐based approach to the prevention, diagnosis and treatment of xerosis cutis. Methods Within a structured decision‐making process, a panel of experienced dermatologists first defined questions relevant to everyday clinical practice, which were then addressed by a systematic review of the literature. Based on the evidence available as well as expert consensus, diagnostic and treatment algorithms were subsequently developed and agreed upon. Results Xerosis cutis is generally diagnosed on clinical grounds. Possible trigger factors must be avoided, and comorbidities should be adequately and specifically treated. Suitable skin care products should be chosen with a view to improving skin hydration and restoring its barrier function. They should therefore contain both rehydrating and lipid‐replenishing components. The “drier” the skin appears, the greater the lipid content should be (preferably using water‐in‐oil formulations). The choice of ingredients is based on a patient's individual symptoms, such as scaling (e.g., urea), fissures/rhagades (e.g., urea or dexpanthenol), erythema (e.g., licochalcone A) and pruritus (e.g., polidocanol). Other factors to be considered include the site affected and patient age. Ingredients or rather combinations thereof for which there is good clinical evidence should be preferentially used. The best evidence by far is available for urea, whose efficacy in the treatment of xerosis is further enhanced by combining it with other natural moisturizing components and ceramides. The “xerosimeter” is a tool developed in an effort to facilitate patient management and for training purposes. It not only includes practical tools for diagnosis and follow‐up but also a classification of ingredients and a structured treatment algorithm. Conclusion The structured symptom‐ and evidence‐based approach proposed herein contains a road map for diagnosis and treatment of xerosis cutis. It aims to raise awareness in terms of prevention and early treatment of this condition and may thus improve quality of life and prevent potential sequelae.

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“…Auch bei der Fußxerosis wies ein ceramid haltiges Externum in Kombination mit 10 % Urea, Glycerin, Fettsäuren, Allantoin und Panthenol eine schnellere Reorganisation der Lipidlamellen im Stratum corneum, eine stärkere Verbesserung des TEWL und der Hydratisierung der Haut im Vergleich zum Vehikel auf …”

Section: Management Der Xerosis Cutisunclassified