The influence of topical prostaglandins on HSA-induced uveitis in the rabbit

Abstract

In this study the effect of topical administration of prostaglandins (PGs) on a human serum albumin (HSA)-induced uveitis is evaluated. Topical prostaglandin E1 (PGE1) and prostaglandin F2 alpha (PGF2 alpha) partly inhibited hyperaemia and flare in the anterior chamber after the induction of immune complex uveitis. A marked increase in the cellular response was observed in the aqueous humour after topical PGE1 and PGF2 alpha. Topical prostaglandins may decrease endogenous prostaglandin formation and reduce the prostaglandin-mediated inflammatory symptoms; on the other hand, they also stimulate the aqueous cellular response, possibly by facilitation of leukotriene formation. These results indicate that topical prostaglandins should not be used to treat immunogenic uveitis.

Models in Ophthalmology and Vision Research

“…Intravitreal injection of bovine serum albumin in presensitized rabbits induced a bilateral uveitis, more severe in the injected eye, that was characterized by an acute elevation of intraocular pressure (lOP) (Uusitalo, 1984;Jamieson et aI., 1989). Similar responses were obtained using human serum albumin (Verbey et aI., 1988;Hoyng, 1989) or egg albumin (Bonnet et aI., 1976). A single intravitreal injection of horse serum likewise caused an uveitis (Pankowska and Boj, 1990).…”