The influence of topic and systemic administration of copaiba oil on the alveolar wound healing after tooth extraction in rats

Abstract

The Copaiba oil has been used as an auxiliary treatment of inflammations, skin disorders and stomach ulcers, however, in dentistry, this “alternative” medicine has not been investigated yet. The purpose of this study was to evaluate the influence of topic and systemic administration of copaiba oil on the alveolar wound healing after tooth extraction. Twenty-eight wistar male rats had their lower first molar teeth extracted. Subsequently, they were divided in four groups, according to the treatment performed: (a) alveolar socket irrigation with copaiba oil; (b) alveolar socket irrigation with physiological serum; (c) daily gavage with copaiba oil or (d) daily gavage with physiological serum. After the sacrifice, the mandibles were removed and processed in order to obtain decalcified histological sections. The results demonstrated high level of epithelial migration, small number of inflammatory cells and vascular enhancement in the animals which received systemic administration of copaiba oil. The rats treated with topic administration of copaiba oil presented ulcerations and large number of inflammatory cells. An increased bone neoformation was observed in both groups treated with copaiba oil when compared with placebo group. It could be concluded that topic or systemic administration of copaiba oil leads to a better alveolar bone healing, however the topic application on connective tissue should be carefully considered, regarding the whole socket wound healing. Key words:Alveolar wound healing, oil-resin, copaiba.

Effects of Copaiba Oil Topical Administration on Oral Wound Healing

“…We believe that the extract concentration might be pointed as a possible cause to the inefficacity of copaiba oil concerning wound healing observed herein. The antiinflammatory effects of copaiba appear to be enhanced by the systemic administration (Dias da Silva et al, ); thus, the administration route chosen by our group might also have contributed to the lack of effectiveness. We recognize the study design as a limitation that may have implied a lack of significant results.…”

Antibacterial Activity of Rosmarinus officinalis, Zingiber officinale, Citrus aurantium bergamia, and Copaifera officinalis Alone and in Combination with Calcium Hydroxide against Enterococcus faecalis

“…Another study found an almost 100% microbial reduction after preparation with 20% ginger glycolic extract as auxiliary chemical substance, demonstrating high effectiveness against C. albicans, E. faecalis, and E. coli [9]. e oil of copaiba is brownish-yellow and has been shown to have anti-inflammatory, curative, analgesic, antibacterial, antifungal, and antitumor properties [32]. In the present study, copaiba only exhibited bacteriostatic activity against E. faecalis.…”

Immunomodulatory action of Copaifera spp oleoresins on cytokine production by human monocytes

“…Although several authors have investigated the biological and therapeutic properties of Copaifera spp, such as antifungal, antileishmanial, alveolar wound healing after tooth extraction in rats, anti-inflammatory, antioxidant, antimutagenic and others [23][24][25][26], our data exhibited the immunomodulatory action of Copaifera oleoresins.…”