1989
DOI: 10.1016/0167-0115(89)90144-4
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The influence of thyroid hormone status on the hypothalamo-hypophyseal-growth-hormone axis

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1992
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Cited by 21 publications
(35 citation statements)
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“…Other laboratories have recently reported that hypothalamic GRFmRNA levels in rats were increased in hypothyroidism (26,27,61 ) and decreased in hyperthyroidism (61). This negative relationship between GRF mRNA and thyroid function is similar to that which we found between GRF secretion and serum T4.…”
Section: Resultssupporting
confidence: 78%
“…Other laboratories have recently reported that hypothalamic GRFmRNA levels in rats were increased in hypothyroidism (26,27,61 ) and decreased in hyperthyroidism (61). This negative relationship between GRF mRNA and thyroid function is similar to that which we found between GRF secretion and serum T4.…”
Section: Resultssupporting
confidence: 78%
“…Previous studies have raised the possibility that T 2 may have extra-nuclear effects, independent of classical nuclear TRs (Horst et al 1989, Kvetny 1992, Lanni et al 1993, Goglia et al 1994. Both GH and TSH mRNA levels can be regulated at a posttranscriptional level by T 3 (Jones et al 1990, Krane et al 1991. Similarly, ME synthesis in the liver is regulated at both transcriptional and posttranscriptional levels (Dozin et al 1986).…”
Section: Discussionmentioning
confidence: 99%
“…The molecular mechanism(s) by which activation of D 2 DA receptors destabilizes PRL mRNA half-life remains to be clarified. Alterations in one or more of the following mechanisms may be involved: (i) the length of the PRL mRNA poly (A) tail (Diamond & Goodman, 1985, Jones et al 1990), (ii) the effect on the destabilizing sequence elements, such as AU-rich elements, if they exist (Shaw & Kamen 1986), or (iii) the RNA-binding proteins which play a major role in regulating the mRNA half-life (Staton et al 2000).…”
Section: Discussionmentioning
confidence: 99%