The Influence of Thymectomy on Rous Sarcoma Regression

Cotter, P. F.; Collins, W. M.; Dunlop, W.; Corbett, A. C.

doi:10.2307/1589475

Cited by 22 publications

(5 citation statements)

References 11 publications

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“…Growth and subsequent division of tumor cells as well as cellular recruitment via viral-replication genes (30) affect RSV tumor growth. T cells are principally responsible for RSV tumor regression (17,19,38,39). Cross-reactions between tumor antigens and certain MHC haplotypes may impinge on antigen recognition.…”

Section: Discussionmentioning

confidence: 99%

Alloantigen System L Affects the Outcome of Rous Sarcomas¹

Medarova

Briles

Taylor

2002

Exp Biol Med (Maywood)

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This study was designed to examine the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock was 50% Modified Wisconsin Line 3 × White Leghorn Line NIU 4 and 50% inbred Line 6.15-5. Pedigree matings of two B2B5 L1L2 sires to five B2B5 L1L2 dams per sire produced experimental chicks segregating for B and L genotypes. Chicks were inoculated with 20 pock-forming units (pfu) of Rous sarcoma virus (RSV) at 6 weeks of age. Tumors were scored six times over 10 weeks postinoculation after which the tumor scores were used to assign a tumor profile index (TPI) to each chicken. Tumor growth over time and TPl were evaluated by repeated-measures analysis of variance and analysis of variance, respectively. Six trials were conducted with a total of 151 chickens. The major histocompatibility (B) complex affected the responses as the B2B2 and B2B5 genotypes had significantly lower tumor growth over time and TPl than the B5B5 genotype. Separate analyses revealed no significant L system effect in B2B2 or B2B5 backgrounds. However, L genotype significantly affected (P < 0.05) both tumor growth over time and TPl in B5B5 chickens. B5B5 L1L2 birds had TPl significantly lower than B5B5 L1L1 chickens but not B5B5 L2L2. Mortality was lower in the B5B5 L1L2 birds than in B5B5 L2L2 chickens. The L system, or one closely linked, affects the growth and ultimate outcome of Rous sarcomas. The response may depend upon the genetic background as well as MHC type.

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Section: Discussionmentioning

confidence: 99%

Alloantigen System L Affects the Outcome of Rous Sarcomas¹

Medarova

Briles

Taylor

2002

Exp Biol Med (Maywood)

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“…The cell-mediated immune response is an essential protective mechanism of the host against many diseases of poultry (Keller et al, 1987;Cotter et al, 1979;Lillehoj, 1987). As effectors of cell-mediated immunity, natural killer (NK) cells have been shown to be an important part of the primary immune response in mammalian systems (Britten & Huges, 1986), as well as in chickens (Sharma et al, 1978;Sharma & Coulson, 1979).…”

Section: Introductionmentioning

confidence: 99%

JMV‐1 stimulation of avian natural killer cell activity

1992

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SUMMARYThe phenotypic characterization of the non-productive, Marek's disease virus-transformed, lymphoblastoid cell line, JMV-1 and the immunological effects of its cell-free culture supernatant were examined. It was verified that the JMV-1 cell line is an activated T-helper cell line that bears antigens indicative of T-cell activation, and it is not a natural killer or cytotoxic Tcell line. Furthermore, the JMV-1 cell line was shown to be unique among Marek's diseasetransformed cell lines in that JMV-1 cells secrete factors that are able to stimulate in vitro natural killer cell cytotoxicity against the avian tumour cell line, LSCC-RP9, in a 4-h assay. Culturing spleen cells in the presence of JMV-1 supernatant for 4 h stimulates a significant increase in NK cell populations and in la-bearing cell populations, as detected by monoclonal antibody staining. These findings suggest that the protective effects against the parasitic and virally-induced lymphoproliferative poultry diseases, which have been credited to the JMV-1 cell line and to its cell-free culture supernatant, are in part due to lymphokine activation of NK cell cytotoxicity.

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“…The Rous sarcoma system of chickens provides a useful model because sarcomas induced by subcutaneous inoculation of the virus either progress and kill the host or grow for some weeks and then regress. Progression and regression are under the control of one or more genes associated with the major histocompatibility complex [1, 21. The mechanism of regression is immunological, dependent largely upon T cell-mediated immunity [3]. The target antigens that stimulate an immune response could be viral envelope antigens, viral group-specific antigens, tumor-specific surface antigens, embryonic antigens or other undefined antigens [4].…”

Section: Introductionmentioning

confidence: 99%

Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

1987

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Unlike many other tumors, experimentally induced Rous sarcomas in chickens have a definite tendency to regress spontaneously. Regression is under genetic control, but it is immunologically mediated although the target antigens that stimulate an immune response are unknown. Tumor cells in regressing sarcomas were found to express class II major histocompatibility complex (Ia-like) antigens while tumor cells from progressing sarcomas were negative. This suggests that the induction of Ia-like antigen expression has a role in the initiation or perpetuation of regression, similar to that postulated for class II antigen expression in a variety of autoimmune diseases.

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The Influence of Thymectomy on Rous Sarcoma Regression

Cited by 22 publications

References 11 publications

Alloantigen System L Affects the Outcome of Rous Sarcomas¹

Alloantigen System L Affects the Outcome of Rous Sarcomas¹

JMV‐1 stimulation of avian natural killer cell activity

Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

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The Influence of Thymectomy on Rous Sarcoma Regression

Cited by 22 publications

References 11 publications

Alloantigen System L Affects the Outcome of Rous Sarcomas1

Alloantigen System L Affects the Outcome of Rous Sarcomas1

JMV‐1 stimulation of avian natural killer cell activity

Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

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Product

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Alloantigen System L Affects the Outcome of Rous Sarcomas¹

Alloantigen System L Affects the Outcome of Rous Sarcomas¹