Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

Powell, P. C.; Hála, K; Wick, Georg

doi:10.1002/eji.1830170523

Cited by 9 publications

(4 citation statements)

References 17 publications

(8 reference statements)

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“…In addition, MHC class II antigens can be demonstrated on malignant cells whereas they are not present on their normal counterparts [4,22,23]. A number of reports have demonstrated that interferon y can induce or angment the expression of MHC class II antigens on tumor cells [1,16,23,30]. Studies on the level of MHC class II antigens on macrophages in tumor-bearing animals have indicated that the anti-tumor response results not only in a local but also in a widespread systemic increase in MHC class Il antigen expression by macrophages [ l 2].…”

Section: Introductionmentioning

confidence: 99%

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Steerenberg

Jong

Geerse

et al. 1990

Cancer Immunol Immunother

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Intralesional injection of BCG into an established line-10 hepatocellular carcinoma in the strain-2 guinea pig causes regression of the tumor and induction of line-10 immunity. We found that the animals were already protected for a second challenge with line-10 tumor cells 7 days after BCG treatment. We studied whether this early induction of immunity was correlated with the expression of MHC class II antigens on line-10 tumor cells and was correlated with an increased expression of MHC class II antigens on leukocytes in the primary tumor and in the regional lymph node (Ln. axillaris accessorius). The MHC class II antigens and the leukocyte subpopulations were measured with monoclonal antibodies and flow cytofluorometry. In the draining lymph node the number of nucleated cells increased about 10-fold during the first 5 days after intralesional injection of BCG. At this time the MHC class II antigen expression of these cells was increased from 21%-32% in the naive controls to 39%-53% in animals with BCG-treated tumors. This implies that the number of MHC-class-II-positive cells increased about 20-fold in the draining lymph node. Surprisingly, the increase in percentage of MHC-class-II-antigen-positive cells was mainly due to an increase of IgM-positive B cells from 8%-11% to 22%-41% and an increase of IgG-positive B cells from 7%-27% to 25%-44%. In the tumor, BCG treatment induced a small increase of MHC-class-II-antigen-positive cells from 11%-12% to 15%-20%. Probably this increase came not from tumor cells but mainly from a BCG-induced infiltration of mononuclear cells, as an increase of T cells from 14% to 20%, an increase of macrophages from 8% to 18%, and an increase of B cells from 0 to 6% was observed. We conclude that the potentiation of anti-(line-10 tumor cell) immunity correlated with a 20-fold increase of MHC-class-II-antigen-positive cells in the lymph nodes and a small increase in the number of MHC-class-II-antigen-positive tumor-infiltrating cells.

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Section: Introductionmentioning

confidence: 99%

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Steerenberg

Jong

Geerse

et al. 1990

Cancer Immunol Immunother

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“…Our experiments disclosed that circulating lymphocytes are very important in tbe immune process, but, in our case, may not reflect the course of progression or regression of RSV-induced tumours. Tbe change in the composition of infiltrating subpopulations of lymphoid cells is a constant occurrence in the tumour [5]. These changes and the role of these infiltrating cells in the regression process as well as the observed changes in the frequency of B-L + cells in PBL are under furtber analysis.…”

Section: Discussionmentioning

confidence: 99%

“…RSVinduced tumours progress [4]. Tumour cells in regressing sarcomas were found to be positive for MHC class II antigens, while cells in progressitig sarcomas were negative, suggesting a role Tor class II antigen in immunologically mediated regression [5], To analyse Ihis phcnoinenon further we followed the percentages v<^ CD4*. CD8' and B-L^ cells in PBL from tutnourbearing cbickens of botb lines.…”

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Frequency of Chicken CD4⁺ and CD8⁺ Cells. Genetic Control and Effect of Rous Sarcoma Virus Infection

et al. 1992

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In chickens from congenic inbred lines CB and CC that differ only in the major histocompatibility complex (MHC), we observed significantly different percentages of CD4+ and CD8+ cells in peripheral blood lymphocytes (PBL) and spleen. Positive cells were detected by indirect immunofluorescence test as analysed by flow cytometry. In both PBL and spleen cell suspensions, the number of CD4+ cells was significantly higher in CB than in CC chickens, whereas in CC birds there was a higher percentage of CD8+ cells than in CB. These statistically significant differences were under the MHC control. We found no statistically significant influence of regressions or progression of Rous sarcoma virus-induced tumours on the percentage of peripheral T cells and on the interleukin-2 production in vitro.

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“…In chickens of the line CB the tumours regress and in line CC the tumours progress (Plachy et al 1977;Plachy 1988). Tumour cells in regressing sarcomas were found to be positive for B-L (class 11) antigens while tumour cells in progressing sarcomas were negative, suggesting a role for B-L antigens in immunologically mediated regression (Powell et al 1987).…”

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confidence: 98%

Chicken major histocompatibility complex congenic lines differ in the percentages of lymphocytes bearing CD4 and CD8 antigens

et al. 1991

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In the experiments to be described two congenic inbred lines CB and CC and two recombinant lines CB.R1 and CC.R1 were used. All four lines differ only in regard to the major histocompatibility complex (MHC). To determine the percentage distributions of the two cell subsets in peripheral blood lymphocytes (PBL) in these lines, monoclonal antibodies to these two antigens were used. By FACScan there were more CD4+PBL in CB and CB.R1 lines (share B-F/B-L region, controlling class I/class I1 antigens with line CB) than CC and CC.R1, while the reverse was true with CD8+ subsets. There were more CD8+ PBL in the CC and CC.R1 lines and less in CB and CB.R1 lines. The ratio of CD4+ to CD8+ in CB chickens was 3.4 +. 0.2 and in CC chickens 1.6 k 0.1.Keywords: chicken inbred lines, CD4 and CD8 antigens CD4 and CD8 antigens are expressed on peripheral T cells and are important markers that define functional subsets of mature T cells (for rev. see Littman 1987;Bierer et al. 1989). These molecules are able in concert with the antigen-specific.T cell receptor (TCR) to augment or modulate the immune response. CD4 and CD8 were initially described as phenotypic markers for helper T lymphocytes and for cytotoxic and suppressor cells respectively (Williams et al. 1977;Reinherz et al. 1979).Recent studies show that the expression of the CD4 or the CD8 antigen is closely correlated with the functional aspects of these cells and their ability to bind with cells that express either class I or I1 major histocompatibility complex (MHC) antigens specificity (Swain '1981).

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Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

Cited by 9 publications

References 17 publications

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Frequency of Chicken CD4⁺ and CD8⁺ Cells. Genetic Control and Effect of Rous Sarcoma Virus Infection

Chicken major histocompatibility complex congenic lines differ in the percentages of lymphocytes bearing CD4 and CD8 antigens

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Aberrant expression of Ia‐like antigens on tumor cells of regressing but not of progressing Rous sarcomas

Cited by 9 publications

References 17 publications

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Major histocompatibility complex class II antigen expression during potentiation of line-10 tumor immunity after intralesional administration of bacillus Calmette-Guérin

Frequency of Chicken CD4+ and CD8+ Cells. Genetic Control and Effect of Rous Sarcoma Virus Infection

Chicken major histocompatibility complex congenic lines differ in the percentages of lymphocytes bearing CD4 and CD8 antigens

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Frequency of Chicken CD4⁺ and CD8⁺ Cells. Genetic Control and Effect of Rous Sarcoma Virus Infection