The Influence of Thiopentone and Suxamethonium on Cardiovascular and Respiratory Function in the Horse

Tavernor, W. D.; Lees, P.

doi:10.1016/s0034-5288(18)34368-6

Cited by 20 publications

(11 citation statements)

References 8 publications

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“…The pronounced tachycardia associated with this anaesthetic technique provides indirect evidence of increased B-adrenergic activity; this could stimulate muscle glycogenolysis which, in the horse, is R-mediated (Snow 1979). This study and Tavernor and Lees (1970) have shown suxamethonium to be associated with short periods of apnoea and a resultant drop in Pao, was illustrated by Tavernor and Lees (1970); this could stimulate anaerobic glycolysis. The blood lactate changes in Croup B were similar to those in man during surgery (Hall, Young, Holdcroft and Alaghband-Zadeh 1978;Cooper, Holdcroft, Hall and Alaghband-Zadeh 1979;Cooper, Paterson, Mashiter and Hall 1980;Cooper, Paterson, Ward and Hall 1981;Stjernstrom, Jorfeldt and Wiklund 1981a;Hall, Walsh, Paterson and Mashiter 1983).…”

Section: Discussionmentioning

confidence: 60%

“…This iscaused primarily by suxamethoniurn because thiopentone alone produces only small increases in heart rate (Tavenor and Lees 1970). This response can be attenuated by the &blocking agent propranolol, suggesting that the tachycardia is mediated via the sympathetic nervous sytem (Tavenor and Lees 1970). The PCV in Group A rose and fell in parallel with the heart rate.…”

Section: Discussionmentioning

confidence: 97%

“…High circulating levels of fatty acids have been associated with arrhythmias in man (Oliver and Yates 1972). The relatively high values prior to induction could increase the risk of arrhythmia at that time and is likely to be most serious when thiopentone and suxamethonium are used, a technique which is known to cause arrhythmia (Tavernor and Lees 1970), hypoxia and, under certain conditions, an increase in serum potassium (Stevenson 1960;Thompson 1980).…”

Section: Discussionmentioning

confidence: 99%

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Some metabolic and hormonal changes associated with general anaesthesia and surgery in the horse

Robertson

1987

Equine Veterinary Journal

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Summary Three different anaesthetic techniques were studied in normal, healthy Thoroughbred or Thoroughbred type horses. These were (a) acepromazine, thiopentone and suxamethonium; (b) acepromazine, glyceryl guaiacolate and a ‘half‐dose’ of thiopentone; and (c) xylazine and ketamine. Anaesthesia was maintained with halothane vaporised in oxygen and nitrous oxide. All horses underwent either laryngeal or body surface surgery. Heart rate, packed cell colume, blood glucose and lactate, plasma non‐esterified fatty acids, insulin and Cortisol were measured before, during and after surgery. The greatest metabolic and hormonal changes occurred immediately after anaesthetic induction and were different in each group. The combination of acepromazine, glyceryl guaiacolate and a ‘half‐dose’ of thiopentone was associated with the least change in the physiological and metabolic variables measured.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Some metabolic and hormonal changes associated with general anaesthesia and surgery in the horse

Robertson

1987

Equine Veterinary Journal

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“…

Thiopental sodium is widely employed as an anaesthetic and hypnotic agent in medical and veterinary practice. The action of this agent has been extensively studied in horses, cattle, sheep, goats, dogs and pigs (7, 10, 12, 14, 15,26,(30)(31)(32).ThioDental has been emDloved in buffaloes for induction and mainte-I , nance of general anaesthesia in clinical cases (1 3, 16, 20). Preliminary findings on the effects of this agent on blood pressure and clinical symptoms in buffalo calves have been reported (5).

…”

mentioning

confidence: 99%

“…Thiopental sodium is widely employed as an anaesthetic and hypnotic agent in medical and veterinary practice. The action of this agent has been extensively studied in horses, cattle, sheep, goats, dogs and pigs (7, 10, 12, 14, 15,26,(30)(31)(32).…”

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confidence: 99%

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Singh

Mirakhur

Sobti

et al. 1980

Zentralblatt für Veterinärmedizin Reihe A

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Summary Seven clinically healthy buffalo calves (62–194 kg.) were anaesthetized with 5% thiopental sodium (1 g./100 kg.) to evaluate the effects of this agent in this species. There was significant tachycardia without any appreciable abnormality in the electrocardiogram. Anaesthesia was associated with moderate hypotension and a significant gradual decline in central venous pressure. The variations in arterial pCO2 were not consistent. Mild to moderate metabolic acidosis was observed in all the animals and in five calves this was associated with very mild to moderate respiratory acidosis. Moderate to severe arterial hypoxaemia due to fall in pO2 and desaturation of haemoglobin was a consistent feature in all the animals. Haemoglobin‐oxygen affinity was increased. Alterations in packed cell volume, oxyhaemoglobin, total proteins and albumin were not appreciable. Hypoglycaemia was found 24 hours after induction. There was evidence of parasympathetic depression, vascular pooling, hypokinetic hypoxia, alveolar hypofunction in two animals and ventilation‐to‐perfusion abnormalities in five calves. There was no evidence of reduced or defective oxygen consumption. Zusammenfassung Änderungen der Hämodynamik, der Blutgase und des Metabolismus während der Thiopental‐Narkose bei Büffeln Sieben klinisch gesunde Büffelkälber (62–194 kg Körpergewicht) wurden mit Thiopental‐Natrium (5% Lösung, 1 g/100 kg Körpergewicht) narkotisiert und dessen Wirkungen untersucht. Ergebnisse: Signifikante Tachykardie ohne wesentliche EKG‐Abnormitäten. Leichte Abnahme des arteriellen Blutdruckes. Signifikante Senkung des zentralvenösen Druckes. Kein einheitliches Verhalten des arteriellen pCO2. Bei allen Tieren mäßige metabolische Azidose. Mäßige bis schwere arterielle Hypoxämie infolge Senkung des pO2 und O2‐Untersättigung des Hämoglobins bei allen Tieren. Erhöhung der O2‐Affinität des Hämoglobins. Keine nennenswerten Veränderungen des Hämatokritwertes, des Oxyhämoglobins, des Totalproteins und Albumins. Hypoglykämie 24 Stunden nach der Narkose. Im weiteren wurden bei 2 Tieren Symptome einer parasympathischen Tonussenkung und Blutstauungen sowie einer hypokinetischen Hypoxie und alveolären Hypofunktion beobachtet. Bei 5 Tieren traten Abnormitäten des pulmonalen Ventilations‐Perfusions‐Verhältnisses auf. Hinweise auf eine reduzierte oder gestörte O2‐Konsumation wurden nicht festgestellt. Résumé Modifications de l'hémodynamique, des gaz sanguins et du métabolisme lors d'une narcose au thiopental chez des buffles Sept veaux de buffle cliniquement sains (62–194 kg de poids) ont subi une narcose au sodium de thiopental (solution à 5%, 1 g/100 kg de poids) dont les actions ont été examinées. Résultats: Une tachycardie significative sans anomalies manifestes de ECG. Une légère diminution de la pression sanguine artérielle et une diminution significative de la pression veineuse centrale. Aucun comportement homogène du pCO2 artériel. Une acidose métabolique moyenne chez tous les animaux. Une hypoxémie artérielle moyenne à grave à la suite d'un abaissemen...

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Intravenous Anesthetic Drugs

Muir¹

2009

Equine Anesthesia

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The Influence of Thiopentone and Suxamethonium on Cardiovascular and Respiratory Function in the Horse

Cited by 20 publications

References 8 publications

Some metabolic and hormonal changes associated with general anaesthesia and surgery in the horse

Some metabolic and hormonal changes associated with general anaesthesia and surgery in the horse

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Intravenous Anesthetic Drugs

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