Based on the welding process of 1050/6061 aluminum alloy laser deep penetration welding, a nonlinear transient heat conduction model is established by ANSYS to calculate the temperature field during the welding process. The model considers the change of physical properties of materials with temperature, and uses APDL programming language to realize the moving loading of Gaussian surface heat source. The numerical simulation shows that the material temperature can reach the melting point within 0.018s, and reach the meteor-like steady process. The temperature gradient at the front end of the heat source is large, and the temperature gradient at the back end is small; In the direction of weld depth, the depth near the melting point of the base metal is 0.55mm; The simulated weld is basically consistent with the weld shape obtained from the test, and the error of penetration width and depth is not more than ± 10%. This study verified the correctness of the simulation method and provided a reference for the welding process and numerical simulation of 1050/6061 aluminum alloy laser deep penetration welding.