The Influence of the Tannic Acid on the Expression of the Connexins 45 in a Rat Kidney Damaged by the Chronic Hyperglycemia

Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet

“…In the present study, as we had already observed (Saric et al, 2017;Luetić et al, 2020), the most prominent expression of Cx45 was observed in proximal tubules, suggesting its involvement in various processes which occur in this part of the nephron. Concerning a notable role of the proximal tubules in the development of tubulointerstitial high-sugar diet fed group; HFHSD+Metf., metformin-treated HFHSD fed group; HFHSD+Lir., liraglutide-treated HFHSD fed group; F, female; M, male.…”

“…So far, the expression of Cx45 has been found in renal vascular smooth muscle cells of afferent and efferent arterioles, intraglomerular and extraglomerular mesangial cells, renin producing juxtaglomerular cells, podocytes and distal tubules (Hanner et al, 2008(Hanner et al, , 2010. Nevertheless, in our previous work (Saric et al, 2017;Luetić et al, 2020), we found that Cx45 is the most prominent Cx expressed in proximal tubules of the rat kidney and its expression is substantially decreased in streptozotocin-induced diabetes mellitus (DM) type 1. However, there are still insufficient data about the exact role of Cx45 and the findings of its distribution in the kidneys are conflicting (Hanner et al, 2010).…”