The influence of the crystalline nature of nano-metal oxides on their antibacterial and toxicity properties

Perelshtein, Ilana; Lipovsky, Anat; Perkas, Nina; Gedanken, Aharon; Moschini, Elisa; Mantecca, Paride

doi:10.1007/s12274-014-0553-5

Cited by 109 publications

(69 citation statements)

References 23 publications

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“…Previous report by [58] showed no TiO2 NP induction of oxidative stress in extracellular environment, while TiO2 treatment produced reactive oxygen species (ROS) only in intracellular conditions. This effect was further correlated with the surface area of NPs indicating particle size and concentration dependent oxidative stress response [58,59]. Our results are in accordance to these findings and showed that TOS levels in the human serum pool were not increased by any of the treatments that contained TiO2, meaning that TiO2 did not increase ROS production in this cell-free environment in any of the tested concentrations.…”

Section: Genotoxic Antigenotoxic and Antioxidative Properties Of Barsupporting

confidence: 90%

Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro

Bajić

Spremo-Potparević

Živković

et al. 2017

Colloids and Surfaces B: Biointerfaces

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Section: Genotoxic Antigenotoxic and Antioxidative Properties Of Barsupporting

confidence: 90%

Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro

Bajić

Spremo-Potparević

Živković

et al. 2017

Colloids and Surfaces B: Biointerfaces

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“…544906) were purchased from Sigma‐Aldrich (Milan, Italy). The sonochemical (sono) ZnO NPs were synthesized by the Gedanken's Lab at the Department of Chemistry, Bar‐Ilan Univesity (Ramat‐Gan, Israel), according to the protocol already reported in previous papers (Perelshtein et al, ).…”

Section: Methodsmentioning

confidence: 99%

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier

Colombo

Cortinovis

Moschini

et al. 2019

J of Applied Toxicology

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ZnO nanoparticles (NPs) are widely used nowadays, thus the gastrointestinal exposure to ZnO NPs is likely to be relevant and the effects on the intestinal barrier should be investigated. Polarized Caco-2 cells were exposed from the apical (Ap) and basolateral (Bl) compartments to increasing concentrations (0, 10, 50 and 100 μg/mL) of sonochemical (sono) and commercial ZnO NPs. The transepithelial electrical resistance (TEER), cell viability, proinflammatory cytokine release and presence of protein oxidative damage were evaluated after exposure. TEER was not significantly affected by Ap exposure to either sono or commercial ZnO NPs at any tested concentrations. After Bl exposure to sono ZnO NPs (all the concentrations) and to 100 μg/mL of commercial ZnO NPs TEER was decreased (P < 0.05). Ap and Bl exposure to 100 μg/mL sono ZnO NPs and Ap exposure to 50 μg/mL commercial ZnO NPs induced a significant (P < 0.05) release of interleukin-6. A significant (P < 0.05) release of interleukin-8 was observed after Ap exposure to ZnO NPs at 100 μg/mL and after Bl exposure to sono ZnO NPs at 100 μg/mL. Ap or Bl exposure to sono or commercial ZnO NPs did not affect tumour necrosis factor-alpha secretion or protein sulphydryl oxidation. In conclusion, the ZnO NP exposure from the Ap compartment appeared almost safe, while the exposure through the basal compartment appeared to be more hazardous and the different NP size and crystallinity seem to affect the mode of action, but further studies are necessary to elucidate better these toxicity mechanisms.

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“…4). 5 As a protection against ROS generation and a disequilibrium of the oxidative balance, bacteria can decrease their intracellular iron level to prevent Fenton reactions. 2), thereby revealing a different mechanism of toxicity.…”

Section: View Article Onlinementioning

confidence: 99%

Influence of structural defects of Ge-imogolite nanotubes on their toxicity towards Pseudomonas brassicacearum

Avellan

Levard

Rose

et al. 2016

Environ. Sci.: Nano

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While the definition of a nanomaterial (NM) is mainly based on size, it is known that decreasing size can induce structural modifications to compensate for increased surface energy. Nevertheless, the influence of these structural modifications on NM toxicity, and in particular structural defects, is poorly studied mainly because of the difficulty in varying the crystallinity of a NM without changing any other morphological parameters. In this study, we used a single-walled alumino-germanate nanotube (Ge-imogolite) as a model, for which this can be achieved. Differences in toxicity of well-crystallized Ge-imogolite vs. Ge-imogolite presenting vacant sites towards the soil bacteria Pseudomonas brassicacearum were studied. Well crystallized tubes led to moderate toxicity attributed to a direct contact with the bacteria and the generation of reactive oxygen species, whereas tubes presenting vacant sites caused more severe toxic effects without any direct contact nor ROS generation. The bacterial growth inhibition in the presence of lacunar tubes was attributed to indirect mechanisms as their higher solubility leads to Al or Ge toxic ion release and/or to the retention of essential nutrients on the vacancies. This study highlights the close correlation between structural defects of a nanomaterial and the modulation of its mechanisms of toxicity.Environ. Sci.: Nano This journal is

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The influence of the crystalline nature of nano-metal oxides on their antibacterial and toxicity properties

Cited by 109 publications

References 23 publications

Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro

Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier

Influence of structural defects of Ge-imogolite nanotubes on their toxicity towards Pseudomonas brassicacearum

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