The influence of the blood levels of lead, aluminum and vanadium upon the arterial hypertension

Granadillo, Víctor; Tahán, Jorge E.; Salgado, O; Elejalde, Luis; Rodríguez‐Iturbe, Bernardo; Romero, Gisela; Romero, Romer A.

doi:10.1016/0009-8981(94)05966-v

Cited by 33 publications

(16 citation statements)

References 12 publications

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“…It was evident that significant higher blood-Pb levels existed Table 3 Blood lead levels (µg/L) in male and female normal subjects of different age groups in the hypertensive older age group. Similar observation was found in Venezuela that a relationship exists between the whole blood-Pb levels and hypertension (Granadillo et al, 1995). The higher levels of Pb in blood samples of hypertensive patients could be attributed to higher intake of these metals through dietary items, environment or due to malfunction in the metabolism of Pb which ultimately developed hypertension.…”

Section: Resultssupporting

confidence: 68%

Non-occupational lead exposure and hypertension in Pakistani adults

Rahman

Khalid

Zaidi

et al. 2006

J. Zhejiang Univ. - Sci. B

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Abstract:Hypertension is one of the most prevalent diseases in the developed and developing countries. Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposure a study was carried out to determine if an association existed between low blood lead concentration and hypertension. In this study the effects of low-level exposure to lead on blood pressure were examined among 244 adults using atomic absorption spectrometer. For quality assurance purpose certified reference materials i.e., Animal blood A-13, Bovine liver 1577 and cotton cellulose V-9 from IAEA (International Atomic Energy Agency) and NIST (National Institute of Standard Technology) were analyzed under identical experimental conditions. The mean age of hypertensive adults was 52 years (range 43~66). The mean values of systolic and diastolic blood pressure were (209±11.7) (range 170~250) and (117±3.9) (range 105~140) mmHg respectively. Blood lead concentration ranged from 78~201 µg/L with a mean of 139 µg/L and 165~497 µg/L with a mean of 255 µg/L in normal and hypertensive adults respectively. Increase in systolic blood pressure was significantly predictive with increase in blood lead levels. Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure.

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Section: Resultssupporting

confidence: 68%

Non-occupational lead exposure and hypertension in Pakistani adults

Rahman

Khalid

Zaidi

et al. 2006

J. Zhejiang Univ. - Sci. B

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“…Anthropogenic activities have increased the dispersion and accumulation of several harmful chemicals in the environment [43]. The accumulation of high levels of metals and metalloids in the human body may create toxicological impacts, and it also poses a challenge for authorities in the public health and industrial hygiene sectors [43,44].…”

Section: Discussionmentioning

confidence: 99%

“…Blanks, standards and sample solutions were prepared in a similar acid matrix. The validity and efficiency of the microwave-assisted digestion method was checked with certified values of CRMs and with those obtained from conventional wet acid digestion method on same CRM (42,43) (Table 3). Mean values for all the metals differed less than 1-2% from the certified values.…”

Section: Microwave-assisted Acid Digestion (Mwd)mentioning

confidence: 99%

Levels of Arsenic, Cadmium, Lead, Manganese and Zinc in Biological Samples of Paralysed Steel Mill Workers with Related to Controls

Afridi

Kazi

et al. 2011

Biol Trace Elem Res

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The determination of essential trace and toxic elements in the biological samples of human beings is an important clinical screening procedure. This study aimed to assess the possible effects of environmental exposure on paralysed male workers (n = 75) belonging to the production and quality control departments of a steel mill. In this investigation, the concentrations of arsenic, cadmium, lead, manganese and zinc were determined in biological samples (blood, urine and scalp hair samples) of exposed paralysis and non-paralysed steel mill workers. For comparative purposes, unexposed healthy subjects of same age group were selected as referents. The elements in the biological samples were measured by atomic absorption spectrophotometry prior to microwave-assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials. The results indicate that the level understudy elements in all three biological samples were significantly higher in paralysed workers of both groups (quality control and production) as compared to referents (p < 0.01). The possible connection of these elements with the aetiology of disease is discussed. The results also show the need for immediate improvements of workplace ventilation and industrial hygiene practices.

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“…Two studies reported only on young children (Ͻ10 years), 25,37 two studies were case reports, 45,48 one 66 recruited less than 50 persons, in one 54 owing to missing information the analysis was performed in less than 50 subjects, five estimated exposure from other measurements than the blood lead concentration, 30,77,78,81,88 and 11 did not provide enough information to compute the association size. 17,19,22,26,27,36,39,62,63,67,86 …”

Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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The influence of the blood levels of lead, aluminum and vanadium upon the arterial hypertension

Cited by 33 publications

References 12 publications

Non-occupational lead exposure and hypertension in Pakistani adults

Non-occupational lead exposure and hypertension in Pakistani adults

Levels of Arsenic, Cadmium, Lead, Manganese and Zinc in Biological Samples of Paralysed Steel Mill Workers with Related to Controls

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

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