An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Nawrot, Tim S.; Thijs, Lutgarde; Hond, Elly M. Den; Roels, Harry; Staessen, Jan A.

doi:10.1038/sj.jhh.1001300

Cited by 206 publications

(137 citation statements)

References 89 publications

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“…It is well-known that Pb and Cd are toxic and carcinogenic metals (Nawrot et al, 2002). It has been suggested that Pb has a facilitating role in the carcinogenesis through inhibition of DNA synthesis and repair, oxidative injury and interaction with DNA-binding proteins and tumor suppressor proteins (Inskip et al, 1995;Wijngaarden and Dosemeci, 2006).…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Trace Elements in Patients with Prostate Cancer

Kaba¹,

Pirinççi²,

Yüksel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.

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Section: Discussionmentioning

confidence: 99%

Serum Levels of Trace Elements in Patients with Prostate Cancer

Kaba¹,

Pirinççi²,

Yüksel³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…On the basis of data from animals and humans, Cd in food soon becomes absorbed in the blood, then becomes present in plasma, and later binds to red blood cells [34,35]. Cd is established toxic and carcinogenic metals [36,37]. Cd does not induce direct DNA damage, however it induces increase in reactive oxygen species (ROS) formation, which in turn induce DNA damage and can also interfere with cell signalling.…”

Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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“…Lead has an exceptionally long half-life in bone compared to other elements (Aufderheide 1989). The many TEs, As, Cd, cobalt, antimony, and mercury (Hg) can deposit in the bone from respiratory exposure (Oakberg et al 2000). Toxic elements (As, Cd, Hg, and Pb) may deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species, such as superoxide anion, hydrogen peroxide, and hydroxyl radical (Goyer 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Toxic elements (Cd, Hg, Ni, Pb, and As) may deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species such as superoxide anion, hydrogen peroxide, and hydroxyl radical (Goyer 1996). The intake of trace and TEs may promote RA disorders by increasing oxidative stress (for example, by catalyzing the production of reactive oxygen species or inhibiting their degradation) due to the deficiency of an antioxidant element and by increasing blood pressure levels (Nawrot et al 2002). The deficiency of essential nutrients, lack of homeostatic control, or an excess intake of some TEs causes chronic physiological disorders, such as RA, diabetic mellitus, and cardiovascular disease (Nawrot et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers

Afridi

Talpur

Kazi

et al. 2015

Environ Monit Assess

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Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining the health. A significant flux of heavy metals, among other toxins, reaches the lungs through smoking. In the present study, the relationship between toxic element (TE) exposure via cigarette smoking and rheumatoid arthritis incidence in population living in Dublin, Ireland, is investigated. The trace {zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se)} and toxic elements arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) were determined in biological (scalp hair and blood) samples of patients diagnosed with rheumatoid arthritis, who are smokers living in Dublin, Ireland. These results were compared with age and sex-matched healthy, nonsmoker controls. The different brands of cigarette (filler tobacco, filter, and ash) consumed by the studied population were also analyzed for As, Cd, Hg, and Pb. The concentrations of trace and TEs in biological samples and different components of cigarette were measured by inductively coupled plasma mass spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials. The recovery of all the studied elements was found to be in the range of 96.4-99.8 % in certified reference materials. The filler tobacco of different branded cigarettes contains Hg, As, Cd, and Pb concentrations in the ranges of 9.55-12.4 ng, 0.432-0.727 μg, 1.70-2.12 μg, and 0.378-1.16 μg/cigarette, respectively. The results of this study showed that the mean values of As, Cd, Hg, and Pb were significantly higher in scalp hair and blood samples of rheumatoid arthritis patients as compare to healthy controls, while Zn, Cu, Mn, and Se concentrations were found to be lower in rheumatoid arthritis patients, the difference was significant in the case of smoker patients (p<0.001). The levels of four toxic elements were 2-3-folds higher in scalp hair and blood samples of nonrheumatoid arthritis smoker subjects as compared to nonsmoker controls. The high exposure of toxic metals as a result of cigarette smoking may be synergistic with risk factors associated with rheumatoid arthritis.

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An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Cited by 206 publications

References 89 publications

Serum Levels of Trace Elements in Patients with Prostate Cancer

Serum Levels of Trace Elements in Patients with Prostate Cancer

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers

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