The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women

Adiponectin Level and Gene Variability Are Obesity and Metabolic Syndrome Markers in a Young Population

“…In contrast, some other studies demonstrated that the common -11377C allele was strongly associated with obesity and MetS parameters (17,52). Our findings are also consistent with previous reports in different populations and different age groups (53,54,55) stating that ADIPOQ gene may play an important role in MetS. Results of these reports pointed that regional differences in body fat affected the risk of metabolic abnormalities, and also ADIPOQ gene variants were suggested as modulators of visceral fat accumulation.…”

“…The effects of the candidate gene markers could be validly evaluated after controlling for environmental factors (e.g. physical activity, diet, smoking) and ethnicity (6,55). Finally, the answer to the question of whether or not the findings from this study can be generalized to Croatian population remains uncertain because analysis was performed in a rather small group.…”

SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

“…in Korea reported significantly higher serum adiponectin in non-diabetic patients with the TT genotype than in those with the GG or GT genotype (Shin et al, 2006;Jang et al, 2008). However, significant reductions in insulin resistance and increases in adiponectin concentration during weight loss have been observed (Haluzík et al, 2004), and the same results have been found only in patients with the GG genotype but not in T-allele carriers in overweight or obese Koreans (Shin et al, 2006).…”

“…Genetic studies in humans have also provided strong evidence of an association between various SNP of human adiponectin gene and metabolic phenotypes (Yang and Chuang, 2006). The common adiponectin SNP, 276G4T, in intron 2 is reported to be associated with obesity, MetS, and T2DM among elderly Taiwanese (Yang et al, 2007) and with several components of MetS in non-obese, non-diabetic Koreans (Jang et al, 2008).…”

The FTO rs9939609, ADIPOQ rs1501299, rs822391, and ADIPOR2 rs16928662 Polymorphisms Relationship to Obesity and Metabolic Syndrome in Bulgarian Sample

“…However, association studies of these two SNPs, either independently or as a haplotype, have resulted in conflicting evidence in different populations and sample types (14). The +276G allele in rs1501299 has been associated either with increased or with decreased levels of plasma total adiponectin in different Caucasian populations (22,35), while this allele has been positively associated with obesity in Sweden (4), but not in Finland (18). Reverse associations with insulin resistance (IR) were also observed for SNP +276G>T in Italian (25) versus Japanese (33) and Polish populations (6).…”