Adiponectin Level and Gene Variability Are Obesity and Metabolic Syndrome Markers in a Young Population

Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population

“…The physiological mechanisms supporting a link between adiponectin and insulin sensitivity include increased glucose utilization and fatty-acid oxidation in skeletal muscle, suppression of glucose production in the liver, increased storage of triglyceride in the adipocyte and increased synthesis and turn-over of triglycerides in brown adipose tissue [2], [3], [56]–[59]. The significant associations we found between the promoter ADIPOQ SNP rs266729, serum adiponectin level and insulin resistance are in line with previous reports [18], [27], [28], [45], [46], [60]–[62]. It is noteworthy that the SNP rs266729 effect on insulin resistance significantly exceeds its predicted effect in the Mendelian randomization experiment.…”

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

“…They are also in agreement with data of studies of French Caucasians (Vasseur et al, 2002), Swedish Caucasians (Harvest et al, 2004), Croatian (Karmelic et al, 2012) and Chinese (Sun et al, 2008;Wanga et al, 2009;Min et al, 2011;Yang et al, 2008;Wang et al, 2009) populations.…”

ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children

“…Regarding links between rs266729 and MetS, early studies reported varying results. 27,28 The rs182052 was associated with an increased risk of the prevalence of obesity in adult Korean women, but there were no significant interactions observed between the genotype of ADIPOQ rs182052 and dietary intake on BMI and body fat mass. These findings suggest that the obesity-related variables may be more dominantly affected by the genotype of ADIPOQ rs182052 than dietary intake in middle-aged Korean women.…”