ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children

Peralta‐Romero, Jesús; Karam-Araujo, Roberto; García, Ana Isabel Burguete; Velasco, Barbara Ixchel Estrada; Islas, Claudia López; Figueroa-Arredondo, Paula; Salgado, A.; Cruz, Miguel

doi:10.1016/j.bmhimx.2015.02.002

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…The authors found that the ADIPOQ-rs2241766 genetic variant was associated with obesity in the overall populations (GG v. TT, OR = 1•39, 95 % CI 1•11, 1•73) (46) . On the other hand, some cross-sectional studies reported results different from those found in our longitudinal analysis (20,47) . In a cross-sectional study on 1469 Mexican children aged 6-12 years, the authors observed no association between the ADIPOQ-rs2241766 gene variant and overweight/ obesity (20) .…”

Section: Discussioncontrasting

confidence: 99%

“…On the other hand, some cross-sectional studies reported results different from those found in our longitudinal analysis (20,47) . In a cross-sectional study on 1469 Mexican children aged 6-12 years, the authors observed no association between the ADIPOQ-rs2241766 gene variant and overweight/ obesity (20) . Another cross-sectional study including 453 Turkish children and adolescents aged 6-17 years also found no difference in the TT (wild type) or non-TT (TG þ GG) genotype between the obese and non-obese groups (47) .…”

Section: Discussioncontrasting

confidence: 99%

“…Genetic variants of adiponectin (ADIPOQ) and leptin (LEP) play a role in energy balance and appetite regulation (12,13,(15)(16)(17) and are associated with BMI and adiposity (17)(18)(19)(20)(21)(22) . Circulating levels of adiponectin are under substantial genetic influence (23) , and variants in the ADIPOQ gene may therefore be associated with the pathophysiology of obesity (24) .…”

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confidence: 99%

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Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll¹,

Farias²,

Kac³

et al. 2020

Br J Nutr

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Excess body weight confers a high risk to human health. Body weight variation between subjects can be partially explained by genetic differences. The aim of this study was to investigate the association of genetic variants in the ADIPOQ (rs2241766) and LEP (rs7799039) genes with body weight trajectories in children from birth to six years of age. This was a prospective cohort (PREDI Study). Socioeconomic, biological and anthropometric data were collected at four time points: at birth in the maternity unit; 1-2 years old, 4-5 years old, and 6 years old at the participant’s home. Genotyping was performed by PCR-RFLP. Poisson regression and linear mixed-effect regression models were used to address the association of ADIPOQ and LEP genotypes with BMI. Excessive body weight at pre-pregnancy (β=0.339, p=0.01) and excessive gestational weight gain (β=0.51, p<0.001) were associated with children’s BMI trajectory from birth to six years. The ADIPOQ-rs2241766 TG or GG genotype was associated with a higher risk of excess body weight in the first six years of life (both sexes: RR=1.25, 95%CI: 1.01-1.56; female: RR=1.67, 95%CI: 1.20-2.31). BMI increased over the years according to the presence of the TG or GG genotype (β=0.01, 95%CI: 0.01-0.02), particularly in females (β=0.02, 95%CI: 0.01-0.04). The ADIPOQ-rs2241766 TG and GG genotypes increased the risk of excess body weight in children from birth to six years of age and had a positive effect on body weight trajectories in girls. The LEP-rs7799039 genetic variant was not associated with body weight trajectory in children.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

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Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll¹,

Farias²,

Kac³

et al. 2020

Br J Nutr

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“…Interestingly, the results of this meta-analysis suggested that polymorphisms in the adipokine genes, ADIPOQ, IL-1β, IL-6, and TNF-α , increase the risk of obesity [19]. Our results are consistent with three studies in Mexican children that showed no contribution of several polymorphisms in ADIPOQ gene (rs2241766, rs182052, rs266729, and rs822393) in children obesity [9, 20, 21]. A similar effect was observed in TNF-α and interleukin-10 [22], suggesting that genetic variants in adipokines do not have a significant effect in Mexican-Mestizo children obesity.…”

Section: Discussionsupporting

confidence: 89%

Polymorphisms in Adipokines in Mexican Children with Obesity

Jiménez-Osorio

Aguilar-Lucio

Cárdenas-Hernández

et al. 2019

International Journal of Endocrinology

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The high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity. This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study. The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942). No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.

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“…Concerning biochemical parameters, we found an altered lipid profile when either BMI or BFP was used to classify obesity, while higher HbA1c levels were found in the obesity group only when BFP was the classification criterion. These results are in agreement with the previous studies in Mexican children reported by Aradillas-García et al [ 29 ] and Peralta-Romero et al [ 30 ], where BMI was also the obesity diagnosis criterion; they found that glucose, total cholesterol, LDL cholesterol, and triglycerides were significantly higher and that HDL was lower in the obesity group compared with the normal-weight group.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children

et al. 2020

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Obesity is a major health problem worldwide and constitutes a sanitary emergency in Mexico, especially childhood obesity. Several studies have proved the relationship between obesity and oxidative stress and the influence of genetic predisposition. This work was aimed to analyze the association of antioxidant enzyme polymorphisms with overweight and obesity in Mexican children and adolescents. A case-control study was performed in 585 children and adolescents aged 3 to 17 years, using two criteria to classify obesity: body mass index (BMI) and body fat percentage (BFP). Anthropometric and biochemical measurements were carried out, and malondialdehyde serum levels were determined. Genotyping was done with the Axiom Genome-Wide LAT microarray, including 68 single nucleotide polymorphisms (SNPs) of the glutathione peroxidase (GPX) and paraoxonase (PON) families. We found six haplotypes associated with obesity—two of them (one in GPX3 and the other in GPX5 and GPX6) in a protective direction when obesity was classified by BMI. The other four haplotypes were associated with obesity when classification was based on BFP—one of them in GPX3 in a protective direction and the others in PON genes conferring obesity risk. In addition, two SNPs, GPX3 rs922429 and GPX4 rs2074451 showed protection against obesity classified by BFP. This study showed genetic susceptibility to oxidative stress in relation to obesity in Mexican children and opens up the possibility that some genetic loci related to obesity are not identified when weight classification is based on BMI.

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ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children

Abstract: The presence of rs11061971 of ADIPOR2 variant confers protection against obesity and could be used as a marker in Mexican children.

Cited by 9 publications

References 31 publications

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Polymorphisms in Adipokines in Mexican Children with Obesity

Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children

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