The Influence of Temperature and Ethanol Concentration in Monacolin K Extraction from Monascus Fermented Rice

Wibowo, Marlia Singgih; Saraswaty, Vienna; Ratnaningrum, Diah; Priatni, Sri; Damayanti, Sophi

doi:10.1016/j.proche.2014.05.029

Cited by 18 publications

(8 citation statements)

References 14 publications

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“…Increasing epidemiological studies indicate that high intake of flavonoids could be associated with a decreased risk of cancer (Batra and Sharma, 2013). In addition, active anticancer compounds such as manocalin K would increase with an increase in the ethanol concentration used for extraction (Singgih et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Antiproliferation activity of water and ethyl acetate red yeast rice fraction against MCM-B2 tumor cells

Hasim¹,

Nasution²,

Priosoeryanto³

et al. 2020

Pharmaciana

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Section: Resultsmentioning

confidence: 99%

Antiproliferation activity of water and ethyl acetate red yeast rice fraction against MCM-B2 tumor cells

Hasim¹,

Nasution²,

Priosoeryanto³

et al. 2020

Pharmaciana

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“…Monacolin K concentration in the supernatant was determined by HPLC (high-performance liquid chromatography). Since the concentration of extracted monacolin K was low (0.08 μg/ml), we tried to improve monacolin K solubilization with different solvents (i.e., ethanol and methanol), following the indications provided by the work of Singgih and colleagues ( Singgih et al, 2014 ). Briefly, RYR was resuspended in methanol and ethanol, agitated with a shaker for 2 h at RT, and the supernatant was collected following centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Anticholesterolemic Activity of Three Vegetal Extracts (Artichoke, Caigua, and Fenugreek) and Their Unique Blend

et al. 2021

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Hepatic-related diseases, in particular hyperlipidemia and hypercholesterolemia, are a thorn on the side of the national health institutes around the globe. Indeed, liver lipid and cholesterol dysregulation could lead to atherosclerotic plaque formation and cardiovascular diseases. Currently, statin administration and monacolin K consumption are the main therapies proposed to counter this alarming connection, but relevant side effects are known. To overcome this issue, safe nutraceutical formulations and/or vegetal extracts, endowed with anticholesterolemic activity, could be instrumental in hypercholesterolemia prevention and treatment. In the present work, the anticholesterolemic efficacy of three vegetal extracts used in traditional medicine (artichoke, caigua, and fenugreek), their unique blend (ACFB), and the monacolin K-containing red yeast extract (RYR), was investigated with an in vitro approach based on hepatic cell line HepG2. The impact on cholesterol of the three extracts, their blend, and RYR were investigated by determining hepatocyte total and free cholesterol and bile acids biosynthesis. According to our results, the anticholesterolemic activity of the vegetal extracts was confirmed, and a novel choleretic activity of caigua extract was evidenced. ACFB showed to be safer than RYR while showing a similar effect on total and free cholesterol and bile acids synthesis compared to it. The anticholesterolemic activity of the blend was obtained with lower vegetal extract concentrations compared with the single vegetal extract, potentially indicating an additive effect between the extracts. In conclusion, the vegetal extracts and their blend, ACFB, are safe and are endowed with anticholesterolemic activity, potentially providing complementary therapies to the statin-based ones for hyperlipidemia and hypercholesterolemia-related complications.

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“…2.3.2. Ekstraksi sampel (Singgih et al, 2014, Arab, Alemzadeh, & Maghsoudi, 2011 Ekstraksi secara maserasi dilakukan dengan cara perendaman sampel dalam pelarut akuades. Sebanyak 40 gram serbuk angkak dalam 400 mL (1:10) sedangkan untuk bekatul, sampel ditimbang sebanyak 40 gram dalam 160 mL (1:4).…”

Section: Pendahuluanunclassified

Aktivitas Penurunan Kadar Glukosa pada Tikus yang Diinduksi Aloksan dari Ekstrak Air Angkak, Bekatul, dan Kombinasinya

Hasim

Faridah

Safithri

et al. 2020

J.Wart.Industri.Has.Pertan.

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The Influence of Temperature and Ethanol Concentration in Monacolin K Extraction from Monascus Fermented Rice

Cited by 18 publications

References 14 publications

Antiproliferation activity of water and ethyl acetate red yeast rice fraction against MCM-B2 tumor cells

Antiproliferation activity of water and ethyl acetate red yeast rice fraction against MCM-B2 tumor cells

Anticholesterolemic Activity of Three Vegetal Extracts (Artichoke, Caigua, and Fenugreek) and Their Unique Blend

Aktivitas Penurunan Kadar Glukosa pada Tikus yang Diinduksi Aloksan dari Ekstrak Air Angkak, Bekatul, dan Kombinasinya

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